| 刘义钊,吴萍,蒯梦妮,等.基于网络药理学的柴芩感冒退热颗粒治疗病毒性感冒的分子关联研究[J].安徽医药,2023,27(10):1923-1926. |
| 基于网络药理学的柴芩感冒退热颗粒治疗病毒性感冒的分子关联研究 |
| Molecular association study of Chaiqin Ganmao Tuire granules in the treatment of viral cold based on network pharmacology |
| |
| DOI：10.3969/j.issn.1009-6469.2023.10.004 |
| 中文关键词: 抗病毒药 网络 Meta分析 柴芩感冒退热颗粒 病毒性感冒 中医药整合药理学平台 分子对接 |
| 英文关键词: Antiviral agents Network meta-analysis Chaiqin Ganmao Tuire granule Viral cold Chinese medicine integrative pharmacology-based research platform of traditional Chinese medicine Molecular docking |
| 基金项目:湖南省中医药管理局指导课题项目( E2022021)；常德市科技计划(指导性)项目( 2020ZD81) |
|
| 摘要点击次数: 584 |
| 全文下载次数: 369 |
| 中文摘要: |
| 目的探讨柴芩感冒退热颗粒治疗病毒性感冒的分子关联机制。方法 2021年 12月至 2022年 1月借助整合药理学平台 V 2.0版本软件的分析功能，建立柴芩感冒退热颗粒治疗病毒性感冒的多维网络，并将核心成分与关键靶标进行分子对接可视化处理。结果分析发现柴芩感冒退热颗粒治疗病毒性感冒的干预作用可能与 Raf激酶抑制蛋白(RKIP)/丝裂原活化蛋白激酶(MAPK)信号级联、蛋白磷酸酶 2A(PP2A)和即刻早期反应基因( IER3)调节胞内磷脂酰肌醇激酶(PI3K)/蛋白激酶 B(AKT)信号通路、核受体转录通路、中性粒细胞脱颗粒、 FCER受体 Ⅰ(FCERⅠ)介导核因子 kB(NF-kB)活化、内源性甾醇、磷脂酰肌醇 -3，4，5三磷酸(PI-3，4，5-P3，PIP3)激活 AKT信号的调节等有关，并通过分子对接发现化合物香蜂草苷、甘草酸等与靶蛋白作用力较强的化合物分子。结论柴芩感冒退热颗粒通过多种活性成分、多靶点、多通路相互作用发挥治疗病毒性感冒作用。 |
| 英文摘要: |
| Objective To explore the molecular correlation mechanism of Chaiqin Ganmao Tuire granule in the treatment of viral cold.Methods From December 2021 to January 2022, a multi-dimensional network of Chaiqin Ganmao Tuire granules in the treatment of viral cold was constructed with the analysis function of integrated pharmacology platform V 2.0 version software, and visualizedthe molecular docking between core components and key targets was also carried out.Results It was found that the intervention effect of Chaiqin Ganmao Tuire granule in the treatment of viral cold may be related to RAF/MAP kinase signaling cascade, PP2A and IER3regulating PI3K/AKT signaling pathway, nuclear receptor transcription pathway, neutrophil degranulation, FCERⅠ-mediated NF-kB activation, endogenous sterols, regulation of AKT signaling activated by PIP3, etc. Molecular docking showed that compounds such asdidymin, Licorice had strong interaction with target proteins.Conclusion Chaiqin Ganmao Tuire granule play a role in the treatmentof viral cold through the interaction of various active components, multiple targets and multiple pathways. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
