| 张建庆,鲁立新,蔡磊,等.急性心肌梗死经皮冠状动脉介入治疗术后微 RNA-208、p21水平与预后的关系[J].安徽医药,2023,27(10):2063-2067. |
| 急性心肌梗死经皮冠状动脉介入治疗术后微 RNA-208、p21水平与预后的关系 |
| Relationship between the levels of miRNA-208, p21 and the prognosis of acute myocardial infarction after percutaneous coronary intervention |
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| DOI：10.3969/j.issn.1009-6469.2023.10.034 |
| 中文关键词: 心肌梗死 经皮冠状动脉介入治疗 微 RNA-208 细胞周期蛋白依赖性激酶抑制因子 p21 预后 |
| 英文关键词: Myocardial infarction Percutaneous coronary intervention MicroRNA-208 Cyclin-dependent kinase inhibitor p21 Prognosis |
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| 中文摘要: |
| 目的探究急性心肌梗死( AMI)经皮冠状动脉介入治疗( PCI)术后微 RNA-208(miRNA-208)、细胞周期蛋白依赖性激酶抑制因子(p21)水平与预后的关系。方法选择 2016年 1月至 2018年 12月在大庆龙南医院接受 PCI治疗的 AMI病人 199例为研究对象。根据随访过程中是否发生主要不良心血管事件( MACE)将病人分为 MACE组( 46例)和非 MACE组( 153例)。采用实时荧光定量 PCR(RT-PCR)和酶联免疫吸附法( ELISA)分别检测受试者血清中 miRNA-208和 p21的表达水平。分析 miRNA-208和 p21水平与 AMI病人 PCI术后发生 MACE的关系。结果 与 MACE组相比，非 MACE组 AMI病人血清中 miRNA-208(1.05±0.21比 1.32±0.26)相对表达水平增高， p21［(1.85±0.39)比( 1.43±0.36)］ kU/L表达水平降低( P<0.05)。 miRNA-208与 p21水平联合预测 AMI病人 PCI术后发生 MACE的曲线下面积( AUC=0.85)高于单一指标预测( 0.79和 0.74)。 miRNA-208高表达组病人发生 MACE的概率显著低于 miRNA-208低表达组( 12.36%比 31.82%)p21高表达组病人发生 MACE的概率显著高于 p21低表达组( 32.65%比 13.21%)，差异有统计学意义( P<0.05)。 Cox单因素及多因素分析显示， miRNA-208［HR 95%CI:0.80(0.40，1.15)］与 p21［HR 95%CI:4.41(2.41，11.35)］水平与 AMI病人 PCI术后发生 MACE密切相关( P<0.05)。结论 AMI病人 PCI术后血清中 miRNA-208、p21水平与预后有关，且 miRNA-208低水平和 p21高水平 AMI病人发生 MACE概率较大。 |
| 英文摘要: |
| Objective To explore the relationship between microRNA-208 (miRNA-208) and cyclin-dependent kinase inhibitor p21levels and prognosis of acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).Methods A total of 199 AMI patients who received PCI treatment in Daqing Longnan Hospital from January 2016 to December 2018 were selected as the researchobjects. Patients were assigned into major adverse cardiovascular events (MACE) group (46 cases) and non-MACE group (153 cases) according to whether MACE occurred during follow-up. The expression levels of miRNA-208 and p21 in serum were detected by real-time fluorescent quantitative PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) respectively. The relationship between the levels of miRNA-208 and p21 and the occurrence of MACE in AMI patients after PCI was analyzed.Results Compared with the MACE group, the relative expression level of miRNA-208 (1.05±0.21 vs. 1.32±0.26) in the serum of AMI patients in the non-MACE group was higher, and the expression level of p21 [(1.85±0.39) vs. (1.43±0.36) kU/L] was lower (P<0.05). The area under the curve (AUC) of the combination of miRNA-208 and p21 levels in predicting the MACE in AMI patients after PCI (0.85) was higher than the single index prediction (0.79 and 0.74). The incidence of MACE in miRNA-208 high expression group was significantly lower than that in miRNA-208 low expression group (12.36% vs. 31.82%), and the incidence of MACE in p21 high expression group was significantlyhigher than that in p21 low expression group (32.65% vs. 13.21%), the difference was statistically significant (P<0.05). Cox univariate and multivariate analysis showed that the levels of miRNA-208 [HR 95%CI:0.80 (0.40,1.15)] and p21 [HR 95%CI:4.41 (2.41,11.35)] were closely related to the occurrence of MACE in AMI patients after PCI (P<0.05).Conclusion The levels of serum miRNA-208 and p21 in AMI patients after PCI are related to the prognosis, and AMI patients with low level of miRNA-208 and high level of p21 have a higher probability of MACE. |
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