| 孙静,石丽媛,康美丽.血清二肽基肽酶 4水平与冠状动脉支架内再狭窄的相关性分析[J].安徽医药,2023,27(11):2190-2193. |
| 血清二肽基肽酶 4水平与冠状动脉支架内再狭窄的相关性分析 |
| Correlation analysis between serum DPP4 level and coronary in-stent restenosis |
| |
| DOI：10.3969/j.issn.1009-6469.2023.11.015 |
| 中文关键词: 二肽基肽酶 4 冠状动脉再狭窄 冠心病 经皮冠状动脉介入术 支架内再狭窄 预测价值 |
| 英文关键词: Dipeptidyl peptidase-4 Coronary restenosis Coronary heart disease Percutaneous coronary intervention In-stent restenosis Predictive value |
| 基金项目:廊坊市科学技术研究与发展计划( 2021013144) |
|
| 摘要点击次数: 980 |
| 全文下载次数: 520 |
| 中文摘要: |
| 目的探讨血清二肽基肽酶 4(DPP4)水平与冠状动脉粥样硬化性心脏病( CAD)病人冠状动脉支架内再狭窄( ISR)的关系。方法选取 2017年 1月至 2021年 1月于河北中石油中心医院行经皮冠状动脉介入( PCI)术的 220例 CAD病人为研究对象，根据 CAD病人 PCI术后 1年内是否发生 ISR将其分为无 ISR组( n=188)和 ISR组( n=32)。比较 ISR组、无 ISR组一般资料及血清 DPP4、C反应蛋白( CRP)水平；分析 CAD病人 PCI术后发生 ISR的影响因素；分析血清 DPP4、CRP对 CAD病人 PCI术后发生 ISR的预测价值。结果 ISR组 CAD病人支架直径小于无 ISR组［(2.82±0.46)mm比( 3.38±0.51)mm，P<0.05］，支架长度长于无 ISR组［( 25.85±3.21)mm比( 23.43±3.15)mm，P<0.05］； ISR组 CAD病人血清 DPP4、CRP水平高于无 ISR组( P<0.05)；支架直径是 CAD病人 PCI术后发生 ISR的保护因素( P<0.05)支架长度、 DPP4、CRP是 CAD病人 PCI术后发生 ISR的危险因素( P<0.05)；血清DPP4、CRP预测 CAD病人 PCI术后发生 ISR曲线下面积( AUC)分别为 0.87、0.70，其截断值分别为 11.89 ng/L、的，15.37mg/L，灵敏度分别为 81.3%、75.0%，特异度分别为 89.4%、54.7%。结论 DPP4在行 PCI术后发生 ISR的 CAD病人血清中水平较高， DPP4有望作为预测 CAD病人 PCI术后发生 ISR的血清标志物。 |
| 英文摘要: |
| Objective To investigate the relationship between serum dipeptidyl peptidase 4 (DPP4) level and coronary in-stent restenosis (ISR) in patients with coronary atherosclerotic heart disease (CAD).Methods A total of 220 CAD patients who underwent per‐cutaneous coronary intervention (PCI) in Hebei CNPC Central Hospital from January 2017 to January 2021 were regarded as the research subjects. According to whether the CAD patients had ISR within 1 year after PCI, they were assigned into the non-ISR group (n= 188) and ISR group (n=32). The general data, serum DPP4 and C-reactive protein (CRP) levels between the ISR group and the non-ISR group were compared; the influencing factors of ISR in CAD patients after PCI were analyzed; and the predictive value of serum DPP4and CRP for ISR in patients with CAD after PCI was analyzed. Results The stent diameter of CAD patients in the ISR group was smaller than that in the non-ISR group [(2.82±0.46) mm vs. (3.38±0.51) mm, P<0.05], and the stent length in the ISR group was longer than that in the non-ISR group [(25.85±3.21) mm vs. (23.43±3.15) mm, P<0.05]; the levels of serum DPP4 and CRP in CAD patients in the ISR group were higher than those in the non-ISR group (P<0.05); stent diameter was a protective factor for ISR in CAD patients after PCI (P<0.05), and stent length, DPP4 and CRP were risk factors for ISR in CAD patients after PCI (P<0.05); the areas under thecurve (AUC) of serum DPP4 and CRP in predicting ISR in CAD patients after PCI were 0.87 and 0.70, respectively, the cut-off values were 11.89 ng/L and 15.37 mg/L, respectively, the sensitivities were 81.3% and 75.0%, respectively, and the specificities were 89.4%and 54.7%, respectively.Conclusion The serum level of DPP4 is higher in CAD patients with ISR after PCI, and DPP4 is expected tobe used as a serum marker to predict the occurrence of ISR in CAD patients after PCI. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
