| 张乐国,贾建普,王丽轩,等.血清趋化素、网膜素 -1水平与缺血性脑血管病颈动脉狭窄的相关性[J].安徽医药,2023,27(11):2194-2198. |
| 血清趋化素、网膜素 -1水平与缺血性脑血管病颈动脉狭窄的相关性 |
| Correlation analysis between serum Chemerin and Omentin-1 levels and carotid artery stenosis in ICVD patients |
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| DOI：10.3969/j.issn.1009-6469.2023.11.016 |
| 中文关键词: 颈动脉狭窄 趋化素 网膜素 -1 缺血性脑血管病 数字减影血管造影 |
| 英文关键词: Carotid stenosis Chemerin Omentin-1 Ischemic cerebrovascular disease Digital subtraction angiography |
| 基金项目:河北省医学科学研究课题计划( 20211278) |
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| 中文摘要: |
| 目的探究血清趋化素、网膜素 -1水平与缺血性脑血管病( ICVD)病人颈动脉狭窄的相关性。方法选取 2017年 2月至 2020年 1月在沧州市中心医院诊治 ICVD病人 60例为研究对象，并选择同期 30例健康体检者为对照组。收集所有病人的一般临床资料。 ICVD病人均接受数字减影血管造影( DSA)并计算动脉狭窄率，并将病人分为轻度狭窄组和中重度狭窄组，采用双抗体夹心免疫吸附法检测病人血清趋化素、网膜素 -1水平。检测三组病人的实验室指标，并采用 Pearson相关性分析趋化素、网膜素 -1水平与实验室指标的关系。 ROC曲线分析趋化素、网膜素 -1对病人发生中重度狭窄的评估价值。结果与对照组相比，轻度狭窄组和中重度狭窄组病人血清趋化素水平依次升高，而网膜素 -1水平依次下降，均差异有统计学意义( P<0.05)。实验室指标检测结果显示，与对照组相比，轻度狭窄组和中重度狭窄组病人收缩压( SBP)、三酰甘油( TG)、空腹血糖(FPG)和 C反应蛋白( CRP)水平均显著升高( P<0.05)而高密度脂蛋白胆固醇( HDL-C)水平显著降低( P<0.05)。与轻度狭窄组病人相比，中重度狭窄组病人 SBP、TG、FPG、CRP密度脂蛋白胆固醇( LDL-C)显著升高，而 HDL-C水平显著降低( P<和低，0.05)。Pearson相关性分析显示，趋化素与 SBP、CRP和 LDL-C呈显著正相关(P<0.05)网膜素 -1与 SBP、CRP呈显著负相关(P<0.05)与HDL-C呈显著正相关( P<0.05)。 ROC曲线分析趋化素、网膜素 -1对病人中重度狭窄的评估价值曲线下面积发生，(AUC)分，别为 0.86、0.83，灵敏度分别为 80.00%、80.00%，特异度分别为 83.30%、76.70%。结论血清趋化素、网膜素 -1水平的异常表达与 ICVD病人颈动脉狭窄存在一定的关系，且对疾病的发展评估有重要意义。 |
| 英文摘要: |
| Objective To explore the correlation between serum Chemerin and Omentin-1 levels and carotid artery stenosis in patients with ischemic cerebrovascular disease (ICVD).Methods Sixty patients with ICVD in Cangzhou Central Hospital from February2017 to January 2020 were selected as the research subjects, and 30 healthy subjects were selected as the control group during thesame period. The general clinical data of all patients were collected. ICVD patients received digital subtraction angiography (DSA) andthe arterial stenosis rate was calculated. The patients were divided into mild stenosis group and moderate to severe stenosis group, theserum Chemerin and Omentin-1 levels of the patients were detected by double antibody sandwich immunosorbent method. The laboratory indicators of patients in the three groups were tested, and the Pearson correlation was used to analyze the relationship between thelevels of Chemerin and Omentin-1 and the laboratory indicators. ROC curve was used to analyze the evaluation value of Chemerin and Omentin-1 in patients with moderate to severe stenosis.Results Compared with the control group, the serum Chemerin level of patients in the mild stenosis group and the moderate to severe stenosis group increased sequentially, while the Omentin-1 level decreased sequentially, and the difference was significant (P<0.05). The laboratory index test results showed that compared with the control group,the levels of systolic blood pressure (SBP), triglycerides (TG), fasting plasma glucose (FPG), and C-reactive protein (CRP) patients in the mild stenosis group and the moderate to severe stenosis group were significantly increased (P<0.05), while the level of high-density lipoprotein cholesterol (HDL-C) was significantly reduced (P<0.05). Compared with patients in the mild stenosis group, the SBP, TG, FPG, CRP, and low-density lipoprotein cholesterol (LDL-C) in the moderate-to-severe stenosis group were significantly increased, while the level of HDL-C was significantly decreased (P<0.05). Pearson correlation analysis showed that Chemerin was significantly positively correlated with SBP, CRP and LDL-C(P<0.05),Omentin-1 was significantly negatively correlated with SBP, CRP (P<0.05), and was significantly positively correlated with HDL-C(P<0.05). ROC curve analysis showed the areas under the value (AUCs) of Chemerin and Omentin-1 for moderate to severe stenosis in patients were 0.856 and 0.828, respectively, with sensitivities of 80.00 % and 80.00 %, respectively, and specificities of 83.30 % and 76.70%, respectively. Conclusion The abnormal expression of serum Chemerin and Omentin-1 levels is related to carotid artery stenosis in patients with ICVD,and it is of great significance for the evaluation of the development of the disease. |
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