| 郑永,刘杰.趋化素样因子超家族 6和程序性死亡受体 -配体 1在脑胶质瘤中的表达及其与预后的关系[J].安徽医药,2023,27(11):2207-2211. |
| 趋化素样因子超家族 6和程序性死亡受体 -配体 1在脑胶质瘤中的表达及其与预后的关系 |
| Expression of CMTM6, PD-L1 and correlation with prognosis in patients with glioma |
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| DOI：10.3969/j.issn.1009-6469.2023.11.019 |
| 中文关键词: 神经胶质瘤 趋化素样因子超家族 6 程序性死亡受体 -配体 1 预后 |
| 英文关键词: Glioma Chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 Programmed death-ligand 1 Prognosis |
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| 中文摘要: |
| 目的探讨趋化素样因子超家族 6(CMTM6)、程序性死亡受体 -配体 1(PD-L1)与脑胶质瘤病人预后状况的关系。方法选择 2016年 1月至 2017年 1月解放军总医院三中心收治的脑胶质瘤病人 95例(观察组)和颅脑外伤病人 89例(对照组)。采用免疫组化法检测脑胶质瘤组织和正常脑组织的 CMTM6、PD-L1蛋白表达。比较两组 CMTM6、PD-L1蛋白表达的差异。采用电话、门诊结合微信随访获取术后 5年生存相关数据。分析 CMTM6、PD-L1与脑胶质瘤病人预后状况的关系。结果观察组 CMTM6、PD-L1阳性表达率为 85.11%、54.74%，明显高于对照组的 26.97%、13.48%(P<0.05)。高病理级别胶质瘤组织的阳性表达率为 95.24%、73.81%，明显高于低病理级别的 71.70%、39.62%(P<0.05)。 Kaplan-Meier生存分析结果显示， CMTM6阳性表达组的 4、5年累积总生存率较 CMTM6阴性表达组的降低( P<0.05)。 PD-L1阳性表达组的 2、3、4、5年累积总生存率及无病生存率较 PD-L1阴性表达组明显降低( P<0.05)。结论 CMTM6、PD-L1与脑胶质瘤病人病理学分级具有紧密的关系，且两者阳性表达往往提示预后状况不良。 |
| 英文摘要: |
| Objective To investigate the relationship between chemokine-like factor superfamily 6 (CMTM6), programmed death receptor-ligand 1 (PD-L1) and prognosis of brain glioma patients.Methods A total of 95 patients with glioma (study group) and 89 patients with cerebral trauma (control group) admitted to the Third Center of PLA General Hospital from January 2016 to January 2017were selected. The express of CMTM6, PD-L1 in glioma and normal brain tissue were detected by immunohistochemical determination. The differences in CMTM6, PD-L1 expression between the two groups were compared. The survival data at five years after operation were collected by following-up with telephone, outpatient service and WeChat. The relationship between the prognosis and CMTM6, PD-L1 in glioma patients were analyzed.Results The CMTM6, PD-L1 positive expression rate was 85.11%, 54.74%, which were significantly higher than the control group of 26.97%, 13.48%(P<0.05). The positive rate in high pathology grade glioma tissue were95.24% and 73.81%, which were significantly higher than 71.70% and 39.62% in the low pathology grade glioma tissue(P<0.05).Kaplan-Meier survival analysis showed that the rate of 4-year and 5-year cumulative overall survival in CMTM6 positive express groupwas significantly lower than that in the CMTM6 negative express group, the rate of 2-,3-,4-,5-year cumulative overall survival and dis‐ease-free survival in PD-L1 positive express group was lower than that in PD-L1 negative express group(P<0.05).Conclusion CMTM6 and PD-L1 are closely related with pathology classification in patients with glioma, and their positive expression may suggest poor prognosis. |
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