| 朱小山,周汉云,杨峰,等.外周血 CC家族趋化因子配体 21、CXC趋化因子受体 7与阵发性房颤射频消融术后早期复发的相关性分析[J].安徽医药,2023,27(11):2233-2236. |
| 外周血 CC家族趋化因子配体 21、CXC趋化因子受体 7与阵发性房颤射频消融术后早期复发的相关性分析 |
| Correlation analysis of peripheral blood CCL21, CXCR7 and early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation |
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| DOI：10.3969/j.issn.1009-6469.2023.11.025 |
| 中文关键词: 心房颤动 射频消融术 CC家族趋化因子配体 21 CXC趋化因子受体 7 早期复发 |
| 英文关键词: Atrial fibrillation Radiofrequency ablation C-C chemokine ligand 21 CXC chemokine receptor type 7 Early recurrence |
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| 中文摘要: |
| 目的探究血清 CC家族趋化因子配体 21(CCL21)、 CXC趋化因子受体 7(CXCR7)水平与阵发性房颤射频消融术后早期复发的相关性。方法选取 2018年 6月至 2021年 1月襄阳市中心医院收治的 122例接受射频消融术治疗的房颤病人为研究对象，根据射频消融术后 3个月病人是否出现复发分为早期复发组( 19例)和未早期复发组( 103例)。采用酶联免疫吸附(ELISA)法检测病人血清中 CCL21、CXCR7水平，采用受试者操作特征( ROC)曲线评价血清 CCL21、CXCR7预测阵发性房颤射频消融术后早期复发的价值， logistic回归分析影响阵发性房颤射频消融术后早期复发的危险因素。结果与未早期复发组相比，早期复发组病人左心房直径( LAD)、血清超敏 C反应蛋白( hs-CRP)、肿瘤坏死因子 -α(TNF-α)及 CCL21水平较高( P<0.05)，左心室射血分数( LVEF)及血清 CXCR7水平较低( P<0.05)； ROC结果显示，血清 CCL21、CXCR7水平预测术后早期复发的 AUC分别为 0.88、0.87，CCL21为 138.36 ng/L时， CXCR7为 2 113.83 μg/L，具有最优的预测能力，二者联合预测术后早期复发的 AUC为 0.94，灵敏度为 84.20%，特异度为 95.10%。logistic回归分析，结果显示高 LAD值、 CCL21≥138.36 ng/L、CXCR7≤2 113.83 μg/L是阵发性房颤射频消融术后早期复发的危险因素( P<0.05)，高 LVEF值是阵发性房颤射频消融术后早期复发的保护因素( P<0.05)。结论术后早期复发的阵发性房颤病人血清中 CCL21水平上升， CXCR7水平下降，对阵发性房颤射频消融术后早期复发具有一定的预测价值。 |
| 英文摘要: |
| Objective To explore the correlation between serum C-C chemokine ligand 21 (CCL21) and CXC chemokine receptortype 7 (CXCR7) levels and early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation.Methods A total of 122 patients with atrial fibrillation treated by radiofrequency ablation in Xiangyang Central Hospital from June 2018 to January 2021 were selected as the research objects. According to whether the patients had recurrence 3 months after radiofrequency ablation, they were divided into the early recurrence group (19 cases) and the non-early recurrence group (103 cases). Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of CCL21 and CXCR7 in serum of patients, the receiver operating characteristic (ROC) curve wasused to evaluate the value of serum CCL21 and CXCR7 in predicting the early recurrence of paroxysmal atrial fibrillation after radiofrequency ablation, logistic regression was used to analyze the risk factors affecting the early recurrence of paroxysmal atrial fibrillation after radiofrequency ablation.Results Compared with the non-early recurrence group, the early recurrence group had a higher left atrial diameter (LAD), serum hypersensitive C-reactive protein (hs-CRP), tumor necrosis factorα (TNF-α) and CCL21 level (P<0.05), left ventricular ejection fraction (LVEF) and a lower serum CXCR7 level (P<0.05); ROC results showed that the AUC of serum CCL21 and CXCR7 levels for predicting early postoperative recurrence was 0.88 and 0.87, when CCL21 was 138.36 ng/L, CXCR7 was 2 113.83 μg/L,with the best predictive ability, the AUC of the two combination for predicting early postoperative recurrence was 0.94, the sensitivitywas 84.20 %, and the specificity was 95.10%.Logistic regression analysis showed that high LAD value, CCL21≥138.36 ng/L, CXCR7≤2 113.83 μg/L were risk factors for early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation (P<0.05), while highLVEF value was a protective factor for early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation (P<0.05).Conclu? sion The serum levels of CCL21 increased and CXCR7 decrease in patients with paroxysmal atrial fibrillation who relapses early aftersurgery, which has a certain predictive value for the early recurrence of paroxysmal atrial fibrillation after RF ablation. |
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