| 姜倩,范芳芳,姚莉,等.欧洲医药保健网分类系统在中枢神经系统药物相关问题中的干预效果评价[J].安徽医药,2023,27(11):2313-2317. |
| 欧洲医药保健网分类系统在中枢神经系统药物相关问题中的干预效果评价 |
| Evaluation of the effects of pharmaceutical care network Europe classification system on the drug-related problems in clinical application of central nervous system medications |
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| DOI：10.3969/j.issn.1009-6469.2023.11.043 |
| 中文关键词: 中枢神经系统药物 药物相关性副作用和不良反应 欧洲医药保健网分类系统 药物相关问题 药学监护 |
| 英文关键词: Central nervous system agents Drug-related side effects and adverse reactions Pharmaceutical care network Europe (PCNE) Drug-related problems (DRPs) Pharmaceutical care |
| 基金项目:新疆维吾尔自治区药学会科研基金资助项目( YXH201912) |
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| 中文摘要: |
| 目的运用欧洲医药保健网( PCNE)分类系统对中枢神经系统药物相关问题( DRPs)进行分析与评估，为临床药师进行合理用药提供依据。方法选择 2020年 7月至 2021年 7月入住新疆医科大学附属中医医院神经内科并且服用中枢神经系统药物的病人，临床药师从药学服务中对发现的 DRPs进行干预，并借助 PCNE(V9.0)分类系统进行分类汇总。结果纳入 654例服用中枢神经系统药物的病人， 106例( 16.21%)病人共发生 112个 DRPs。其中 DRPs的问题类别集中在治疗安全性(74.11%)和治疗有效性( 16.07%)。 DRPs发生频率较高的药物为抗精神病药、苯二氮?类药、抗焦虑抑郁药、解热镇痛抗炎药及抗痴呆药和改善脑代谢药。 DRPs的原因主要是药物选择( 79.65%)其次是剂量选择( 9.73%)。临床药师共进行了 257次介入，其中 207次介入被接受，成功率为 80.54％。干预接受程度最高的，是药物不良反应上报( 100％)，其次是与病人层面(96.97％)、药物层面( 77.98％)及医师层面( 76.42％)。发生 9例( 1.37%)药物不良反应，临床药师参与评价及干预， 9例病人均转归良好。结论 PCNE分类系统的引入能提升临床药师发现和解决 DRPs的能力，提高临床药师在药学服务中的能力及效率，促进临床合理用药。 |
| 英文摘要: |
| Objective To analyze and evaluate the drug-related problems (DRPs) of central nervous system (CNS) medications byusing the pharmaceutical care network Europe (PCNE) classification system, so as to provide reference for pharmacists to practise pharmaceutical care mode in patients.Methods The neurology inpatients receiving central nervous system (CNS) medication were selected from Affiliated Traditional Medical Hospital,Xinjiang Medical University from July 2020 to July 2021. Clinical pharmacists intervened in the DRPs discovered in pharmaceutical care and classified and summarized them with the help of PCNE (V9.0) classificationsystem.Results A total of 654 inpatients with CNS medication were included, of whom 106 patients (16.21%) developed 112 DRPs.The DRPs question categories focused on safety of treatmentt (74.11%) and efficacy of treatment (16.07%). Drugs with higher frequencyof DRPs are antipsychotics, benzodiazepines, anti-anxiety and depression drugs, antipyretic, analgesic, anti-inflammatory and anti-dementia drugs, and drugs that improve brain metabolism. The reason categories mainly focus on drug selection (79.65%) and dose selection (9.73%). Clinical pharmacists conducted 257 interventions, 207 of which were accepted, with a success rate of 80.54%. The highest acceptance of intervention was adverse drug events reporting (100％), followed by patient level (96.97％), drug level (77.98%) anddoctor level (76.42%). Adverse drug reactions occurred in 9 patients (1.37%), whom recovered well with the intervention of clinicalpharmacists. Conclusion The introduction of PCNE classification system can improve the ability of clinical pharmacists to discoveand solve DRPs, improve the ability and efficiency of clinical pharmacists in pharmaceutical care, promote clinical rational drug use. |
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