| 王海波,邓晓军.绿色化学理念下奎宁苯甲酰酯金鸡纳生物碱衍生物的微波无溶剂合成的有机化学自主设计性教学实验[J].安徽医药,2023,27(11):2322-2326. |
| 绿色化学理念下奎宁苯甲酰酯金鸡纳生物碱衍生物的微波无溶剂合成的有机化学自主设计性教学实验 |
| Organic chemistry self-designed teaching experiment of microwave solvent-free synthesis of quinine benzoyl ester cinchona alkaloid derivatives under the concept of green chemistry |
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| DOI：10.3969/j.issn.1009-6469.2023.11.045 |
| 中文关键词: 教学 化学，有机 绿色化学 自主设计性实验 微波合成法 金鸡纳生物碱 |
| 英文关键词: Teaching Chemistry,organic Green chemistry Self-designed experiment Microwave synthesis Cinchona alkaloid |
| 基金项目:国家自然科学基金面上项目( 81973236)；中华医学会医学教育研究课题( 2020B-N13348)；陕西高等教育学会高等教育科学研究项目( XGH21245) |
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| 中文摘要: |
| 目的探讨绿色化学理念下开设有机化学自主设计性教学实验的意义。方法基于绿色化学理念，设计奎宁苯甲酰酯类金鸡纳生物碱衍生物的微波无溶剂合成，完成自主设计性教学实验。结果实验内容新颖，涵盖酯类微波无溶剂合成方法、产物后处理、柱层析纯化等操作步骤，与医药学专业的有机化学理论知识契合度高，同时，实验中利用核磁共振氢谱、高分辨质谱等波谱学数据对产物结构进行了表征，对于培养学生将理论课中所学知识点灵活用于实践解决问题的能力起到了积极促进作用，且使学生建立起绿色合成化学的理念。结论该实验不仅能有效提升学生学习的自主性，激发学习兴趣，强化其实验基本操作技能，也使学生对科学研究工作的思路有更好地认识，为其后续其他专业课程的学习打牢基础。 |
| 英文摘要: |
| Objective To investigate the significance of setting up independent design teaching experiment of organic chemistry under the concept of green chemistry.Methods Microwave solvent-free synthesis of quinine benzoyl ester cinchona alkaloid derivatives was designed based on the concept of green chemistry, and self-designed teaching experiment was completed.Results The content of the experimentwas novel, covering the conventional synthesis method of ester compounds, the operation of microwave solvent-free synthesis, product post-treatment, column chromatography purification and other steps, which was highly consistent with the theoreticalknowledge of medical organic chemistry. At the same time, the structure of the product were characterizd by NMR and IR in the experiment. It has played a positive role in cultivating students′ ability to flexibly apply the knowledge learned in theoretical courses to practical problem solving, and enables students to establish the concept of green synthetic chemistry.Conclusion This experiment can notonly effectively enhance students′ learning autonomy, stimulate students′ interest in learning, strengthen their basic experimental operation skills, but also enable students to have a better understanding of the ideas of scientific research work, and lay a solid foundationfor their subsequent learning of other professional courses. |
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