| 黄殊伦,唐昊,吴艳.环状 RNA在肺动脉高压中的研究进展[J].安徽医药,2023,27(12):2333-2338. |
| 环状 RNA在肺动脉高压中的研究进展 |
| Research progress in the role of circRNAs in pulmonary hypertension |
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| DOI：10.3969/j.issn.1009-6469.2023.12.001 |
| 中文关键词: DNA，环状 肺动脉高压 肺动脉平滑肌细胞 肺动脉内皮细胞 细胞焦亡 |
| 英文关键词: DNA, circular Pulmonary hypertension Pulmonary arterial smooth muscle cells Pulmonary arterial endothelial |
| 基金项目:国家自然科学基金( 82173472) |
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| 中文摘要: |
| 环状 RNA是一种稳定、保守的凭借共价键首尾相连的闭合环状 RNA，研究表明环状 RNA和多种疾病的发生发展密切相关。肺动脉高压( PH)是一类以肺血管阻力进行性升高为特征的肺血管疾病，其发病机制尚不明确。近年来越来越多的研究提示环状 RNA在 PH的发生发展中可能扮演重要角色，为 PH的诊断和治疗提供新线索。该文结合环状 RNA在 PH领域的研究现状，综述其在 PH中的作用和机制。 |
| 英文摘要: |
| Circular RNA (circRNA) is a type of stable and conserved RNA molecular with covalently closed loop structures. Severalrecent studies have shown that circRNA is closely related to the occurrence and development of multiple diseases. Pulmonary hyperten.sion is a kind of pulmonary vascular disease characterized by a progressive increase of pulmonary vascular resistance. However, itspathogenesis is still not clear. In recent years, researchers have found that circRNA may play a significant role in the occurrence anddevelopment of pulmonary hypertension, which provides new clues for the diagnosis and treatment of pulmonary hypertension. In thisreview, we elaborate on the mechanism of circRNAs in pulmonary hypertension, based on the research status of circRNAs in pulmonaryhypertension. |
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