| 刘美清,杨逸昊,王月晗,等.颞叶内侧癫痫并抑郁病人脑功能连接密度的静息态功能磁共振成像研究[J].安徽医药,2023,27(12):2378-2383. |
| 颞叶内侧癫痫并抑郁病人脑功能连接密度的静息态功能磁共振成像研究 |
| Resting-state functional magnetic resonance imaging study of brain functional connectivity density in patients with medial temporal lobe epilepsy and depression |
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| DOI：10.3969/j.issn.1009-6469.2023.12.010 |
| 中文关键词: 静息态脑功能磁共振成像(rs-fMRI) 癫痫，颞叶 抑郁症 共病现象 功能连接密度 体积元素 |
| 英文关键词: Resting-state cerebral functional magnetic resonance imaging (rs-fMRI) Epilepsy, temporal lobe Depressive disor. der Comorbidity Functional connectivity density Volume element |
| 基金项目:国家自然科学基金项目( 81960249)；海南省自然科学基金项目( 822RC832)；海南省重点研发计划( ZDYF2022SHFZ109)；海南省临床医学中心项目资助( 2021) |
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| 中文摘要: |
| 目的探讨颞叶内侧癫痫伴抑郁( MTLEWD)病人在静息态功能磁共振成像( rs-fMRI)中功能活动异常的脑区的特点。方法纳入 2021年 1—12月在海南医学院第一附属医院神经内科门诊符合国际抗癫痫联盟( ILAE)诊断分类标准的颞叶内侧癫痫病人，根据 HAMD评分将病人分为 MTLEWD组和颞叶内侧癫痫不伴抑郁组(MTLE组)同时纳入与病人性别、年龄相匹配的对照组。使用 GE Discovery MR7503.0T设备根据预先设定参数行磁共振扫描，获取静息态功，能磁共振数据。采用 SPSS 22.0统计分析软件对一般人口学资料进行分析。基于 MATLAB 2018平台采用 DPABI软件对磁共振数据进行预处理，使用功能连接密度( FCD)分析指标对三组被试者行 ANOVA分析差异有统计学意义的脑区，然后行组间两样本的 t检验，根据高斯随机场(GRF)理论满足体素显著性 <0.001、连续体素数量 ≥23，团块显著性 <0.05的区域被认为差异有统计学意义。结果共纳入 MTLE组病人 20例， MTLEWD组病人 21例，对照组 25例，三组病人一般资料(年龄、性别)差异无统计学意义( P>0.05)。三组的 FCD值差异的脑区主要在楔前叶、颞中回、颞下回、左侧小脑 cruse1区、左侧小脑 cruse2区、左侧小脑 7b区、左侧小脑 8区、额中回、左侧颞极(颞上回)、颞极(颞中回)等脑区。结论 MTLEWD病人活动异常脑区主要集中在默认网络相关脑区及小脑，上述脑区功能紊乱与病人的抑郁症状相关；使用 Rs-fMRI分析方法能够客观地对病人进行功能评价。 |
| 英文摘要: |
| Objective To investigate the characteristics of brain regions with abnormal functional activity in resting-state functional magnetic resonance imaging (rs-fMRI) in patients with medial temporal lobe epilepsy with depression (MTLEWD).Methods Patients with medial temporal lobe epilepsy who met the International League Against Epilepsy (ILAE) diagnostic classification criteria at theoutpatient clinic of the Department of Neurology of the First Affiliated Hospital of Hainan Medical College from January to December2021 were enrolled. According to HAMD scores, patients were divided into the medial temporal lobe epilepsy with depression(MTLEWD) group and the medial temporal lobe epilepsy (MTLE) group, and a control group matched to the patient's sex and age wasincluded. Magnetic resonance scans were performed using a GE Discovery MR7503.0T device according to preset parameters to obtainresting-state functional magnetic resonance data. General demographic data were analyzed using SPSS 22.0 statistical analysis soft.ware. The magnetic resonance data were preprocessed using DPABI software based on the MATLAB 2018 platform, and brain regionswith statistically significant differences were analyzed by ANOVA using the functional connectivity density (FCD) analysis index for the three groups of subjects. Then the t test was performed for the two-sample test between the groups, which was satisfied with voxel signif.icance < 0.001, number of consecutive voxels ≥ 23, and clustering significance < 0.05, according to the theory of Gaussian randomfields (GRF). Regions with cluster significance < 0.05 were considered to have statistically significant differences.Results A total of 20 patients in the MTLE group, 21 patients in the MTLEWD group, and 25 patients in the control group were included, and the differ.ences in the general information (age and sex) among the three groups were not statistically significant (P>0.05). The brain regions withdifferent FCD values among the three groups were mainly in the precuneus, middle temporal gyrus, inferotemporal gyrus, left cerebellarcruse 1 region, left cerebellar cruse 2 region, left cerebellar 7b region, left cerebellar 8 region, middle frontal gyrus, left temporal pole(superior temporal gyrus), temporal pole (middle temporal gyrus) and other brain regions.Conclusions The brain regions with abnor. mal activity in MTLEWD patients are mainly concentrated in the default network-related brain regions and the cerebellum, and the dys.function of the above brain regions is related to the depressive symptoms of the patients. Using the rs-fMRI analysis method can objec. tively evaluate the function of the patients. |
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