| 王承霞,夏雷,王晓,等.分泌超高血清甲胎蛋白的胃肝样腺癌 1例[J].安徽医药,2023,27(12):2394-2397. |
| 分泌超高血清甲胎蛋白的胃肝样腺癌 1例 |
| A case of hepatoid adenocarcinoma of the stomach secreting ultrahigh serum AFP |
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| DOI：10.3969/j.issn.1009-6469.2023.12.013 |
| 中文关键词: 胃肿瘤 腺癌 胃肝样腺癌 甲胎蛋白 免疫组化 老年人 |
| 英文关键词: Stomach neoplasms Adenocarcinoma Gastric hepatoid adenocarcinoma α -fetoprotein Immunohistochemis. try Elderly patients |
| 基金项目:国家自然科学基金资助项目( 82002225) |
| 作者 | 单位 | | 王承霞 | Department of Clinical Laboratory, Nanjing, Jiangsu 210009, China | | 夏雷 | Department of Pathology,Nanjing, Jiangsu 210009, China | | 王晓 | Department of CT, Jiangsu Cancer Hospital, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210009, China | | 莫冬萍 | Department of Clinical Laboratory, Nanjing, Jiangsu 210009, China |
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| 中文摘要: |
| 目的提高对胃肝样腺癌( HAS)的临床特点、病理特点、诊断及治疗的认识。方法回顾性分析 2021年 10月 22日江苏省肿瘤医院收治的 1例 HAS病人的临床资料。结果男， 70岁，以“发现胃小弯部腺癌 1周”收入院。胃镜提示胃小弯侧巨大溃疡，肝区未见明显占位，甲胎蛋白( AFP)>1 000 μg/L，经胃病理切片免疫组化诊断为肝样腺癌，后经免疫联合化疗病人 AFP降至 157 μg/L。结论 HAS无特异的临床表现，胃镜及影像学出现胃部肿物、溃疡、淋巴结转移，同时出现无法解释的 AFP异常升高，应该考虑 HAS，做到早发现早治疗。 |
| 英文摘要: |
| Objective To improve the understanding of the clinical features, pathological characteristics, diagnosis and treatment ofhepatoid adenocarcinoma of the stomach (HAS).Methods A retrospective analysis of the clinical data of a patient with HAS admittedto Jiangsu Cancer Hospital on October 22, 2021, was conducted.Results A 70-year-old male was admitted to the hospital with the dis.covery of adenocarcinoma in the lesser curvature of the stomach for 1 week. Gastroscopy showed a large ulcer on the lesser curvature ofthe stomach, with no obvious space occupying in the liver area, and α-fetoprotein (AFP) >1 000 μg/L. Hepatoid adenocarcinoma was di.agnosed by immunohistochemical analysis of gastric pathological sections, and the AFP level of the patient was reduced to 157 μg/L af.ter combined immunochemotherapy.Conclusion HAS has no specific clinical manifestations, and the presence of gastric masses, ul.cers, and lymph node metastasis on gastroscopy and imaging, along with an unexplained abnormally elevated AFP, should be consid.ered for early detection and early treatment. |
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