| 王宪伟,袁风菊,徐培,等.高级别鳞状上皮内病变病人子宫颈切除术后人乳头瘤病毒持续感染的相关危险因素研究[J].安徽医药,2023,27(12):2412-2416. |
| 高级别鳞状上皮内病变病人子宫颈切除术后人乳头瘤病毒持续感染的相关危险因素研究 |
| Risk factors for persistent HPV infection after cervical resection in patients with high-grade squamous intraepithelial lesions |
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| DOI：10.3969/j.issn.1009-6469.2023.12.017 |
| 中文关键词: 宫颈鳞状上皮内病变 乳头状瘤病毒感染 子宫颈切除术 年龄 危险因素 回归分析 |
| 英文关键词: Squamous intraepithelial lesions of the cervix Papillomavirus infections Cervical hysterectomy Age Risk fac. tors Regression analysis |
| 基金项目:四川科技计划项目( 2019YFS0483) |
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| 中文摘要: |
| 目的评估接受宫颈切除术的高级别鳞状上皮内病变( HSIL)病人人乳头瘤病毒( HPV)持续性感染相关的危险因素。方法回顾性分析 2016年 5月至 2018年 7月德阳市人民医院 342例接受宫颈切除术的 HSIL妇女的临床资料，依据术后 HPV检测结果将其分为持续感染组( n=53)和对照组( n=289)。通过单因素和多因素 logistic回归分析评估了病人的临床特征与术后 HPV感染持续性之间的相关性。结果 342例病人中 53例( 15.5%)出现了术后 HPV的持续感染，持续感染组年龄大于对照组年龄［(46.74±6.24)岁比(43.90±8.16)岁］(P<0.05)、持续感染组中绝经、 HPV16/18亚型、宫颈上皮内瘤变 3级(CIN Ⅲ)累及腺体的比例均高于对照组( 45.3%比 31.1%、67.9%比 51.2%、62.3%比 43.3%、47.2%比 32.5%)(P<0.05)多因素 logistic回归、分析显示，年龄 >40岁、 HPV16/18亚型、 CIN Ⅲ是 HSIL病人子宫颈切除术后 HPV持续感染的独立危险因，素。结论年龄 >40岁， HPV16/18亚型， CIN Ⅲ的病人在宫颈切除术后更容易出现 HPV持续性感染，临床医师应加强对此类型病人的随访和术后管理。 |
| 英文摘要: |
| Objective To assess the risk factors associated with persistent human papilloma virus (HPV) infection in patients with high-grade squamous intraepithelial lesions (HSILs) undergoing cervical resection.Methods A retrospective analysis of the clinicaldata of 342 HSIL women who underwent cervical resection in Deyang People's Hospital from May 2016 to July 2018 was performed,and the patients were divided into a persistent infection group (n=53) and a control group (n=289) based on the results of the postopera.tive HPV test. The correlation between the clinical characteristics of the patients and the persistence of postoperative HPV infectionwas evaluated through univariate and multivariate logistic regression analyses.Results Among 342 patients, 53 (15.5%) had persis.tent HPV infection, and the age of the persistent infection group was greater than that of the control group [(46.74±6.24) years vs. (43.90±8.16) years] (P < 0.05). The proportions of menopause, HPV subtypes 16/18, cervical intraepithelial neoplasia grade 3 (CIN Ⅲ),and glandular involvement were higher in the persistently infected group than in the control group (45.3% vs. 31.1%, 67.9% vs. 51.2%, 62.3% vs. 43.3%, and 47.2% vs. 32.5%) (P<0.05), and multivariate logistic regression analysis showed that age>40 years, HPV sub.types 16/18, and CIN Ⅲ were independent risk factors for persistent HPV infection after cervical resection in HSIL patients.Conclu. sion Patients aged > 40 years with HPV subtype 16/18 and CIN Ⅲ are more likely to develop persistent HPV infection after cervicalresection, and clinicians should strengthen the follow-up and postoperative management of these types of patients. |
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