| 胡丹,陈志杰,林燕彬,等.调强放射治疗局部晚期鼻咽癌 489例远期预后影响因素及晚期安全性研究[J].安徽医药,2023,27(12):2460-2464. |
| 调强放射治疗局部晚期鼻咽癌 489例远期预后影响因素及晚期安全性研究 |
| Factors influencing the long-term prognosis and late safety of 489 cases of locally advanced nasopharyngeal carcinoma treated with IMRT |
| |
| DOI：10.3969/j.issn.1009-6469.2023.12.028 |
| 中文关键词: 鼻咽肿瘤 放射疗法，调强适形 放化疗，辅助 预后 安全性 |
| 英文关键词: Nasopharyngeal neoplasms Radiotherapy, intensity-modulated conformal Chemoradiotherapy, adjuvant Progno. sis Safety |
| 基金项目: |
|
| 摘要点击次数: 1070 |
| 全文下载次数: 431 |
| 中文摘要: |
| 目的探讨行调强放射治疗( IMRT)初治局部晚期鼻咽癌远期预后影响因素及晚期安全性。方法回顾性纳入 2012年 1月至 2017年 12月于梅州市人民医院行 IMRT一线治疗的局部晚期鼻咽癌病人共 489例，分析随访生存情况、复发转移及晚期损伤情况，采用单因素和多因素评价局部区域控制率、总生存(OS)率及无复发生存(DFS)率独立影响因素。结果 489例病人随访 5年局部区域控制率为 92.64%(453/489)，5年 DFS率为 84.05%(411/489)，5年 OS率为 91.00%(445/489)。随访过程中死亡 65例，其中因局部区域复发死亡 25例，因远处转移死亡 35例，因其他事件死亡 5例。随访 3~4级晚期损伤发生率为 2.04%(10/489)；单因素分析结果显示，临床分期与 IMRT一线治疗局部晚期鼻咽癌病人 5年局部区域控制率有关( P<0.05)；性别、 EB DNA拷贝数、临床分期及 N分期均与 IMRT一线治疗局部晚期鼻咽癌病人 5年 DFS率有关( P<0.05)；年龄、 EB DNA拷贝数、临床分期及 N分期均与 IMRT一线治疗局部晚期鼻咽癌病人 5年 OS率有关( P<0.05)。 Cox模型多因素分析结果显示，临床分期是 IMRT一线治疗局部晚期鼻咽癌病人 5年局部区域控制率独立影响因素( P<0.05)；性别、年龄、吸烟和 EB DNA拷贝数均是 IMRT一线治疗局部晚期鼻咽癌病人 5年 DFS率独立影响因素(P<0.05)；年龄、 N分期和 EB DNA拷贝数均是 IMRT一线治疗局部晚期鼻咽癌病人 5年 OS率独立影响因素( P<0.05)。结论 IMRT一线治疗局部晚期鼻咽癌远期预后与多种因素有关，包括性别、年龄、 EB DNA拷贝数及分期情况，而随访晚期损伤以 1~2级为主。 |
| 英文摘要: |
| Objective To investigate the influencing factors of long-term prognosis and late safety of locally advanced nasopharyn. geal carcinoma treated with initial treatment of intensity-modulated radiation therapy (IMRT). Methods A total of 489 locally ad. vanced nasopharyngeal carcinoma patients who underwent first-line treatment with IMRT at Meizhou People's Hospital from January2012 to December 2017 were retrospectively included to analyze follow-up survival, recurrent metastasis, and advanced injury and to evaluate the independent influencing factors of local-regional control rate, overall survival (OS) rate, and disease-free survival (DFS) rate by using univariate and multivariate factors. Results The 5-year local-regional control rate of 489 patients at follow-up was 92.64% (453/489), the 5-year DFS rate was 84.05% (411/489), and the 5-year OS rate was 91.00% (445/489). During the follow-up, 65patients died, including 25 deaths due to localized regional recurrence, 35 deaths due to distant metastasis, and 5 deaths due to otherevents. The incidence of grade 3~4 advanced injury during follow-up was 2.04% (10/489). Univariate analysis showed that clinical stage was related to the 5-year local-regional control rate of locally advanced nasopharyngeal carcinoma patients treated with IMRT in the first-line setting (P<0.05). Sex, EB DNA copy number, clinical stage and N stage were all correlated with the 5-year DFS rate of lo. cally advanced nasopharyngeal carcinoma patients treated with IMRT in the first-line setting (P<0.05). Age, EB DNA copy number, clinical stage and N stage were all correlated with the 5-year OS rate of locally advanced nasopharyngeal carcinoma patients treated with IMRT in the first-line setting (P<0.05). Cox model multivariate analysis showed that clinical stage was an independent factor influ. encing the 5-year local regional control rate of locally advanced nasopharyngeal carcinoma patients treated with IMRT in the first-line setting (P<0.05). Sex, age, smoking and EB DNA copy number were independent influencing factors for the 5-year DFS rate of locally advanced nasopharyngeal carcinoma patients treated with IMRT in the first-line setting (P<0.05). Age, N stage and EB DNA copy num. ber were independent influencing factors of the 5-year OS rate of locally advanced nasopharyngeal carcinoma patients treated with IMRT in the first-line setting (P<0.05).Conclusion The long-term prognosis of locally advanced nasopharyngeal carcinoma treated with IMRT in the first-line setting is related to a variety of factors, including sex, age, EB DNA copy number, and staging status, where. as the follow-up advanced injury is predominantly grade 1 to 2. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
