| 王志刚,申改青,黄玉焕.幽门螺杆菌感染与儿童哮喘发病的相关性分析[J].安徽医药,2023,27(12):2479-2482. |
| 幽门螺杆菌感染与儿童哮喘发病的相关性分析 |
| Correlation between Helicobacter pylori infection and asthma in children |
| |
| DOI：10.3969/j.issn.1009-6469.2023.12.032 |
| 中文关键词: 哮喘 幽门螺杆菌 辅助性 T细胞 1/辅助性 T细胞 2 辅助性 T细胞 17/调节 T细胞 儿童 |
| 英文关键词: Asthma Helicobacter pylori Th1/Th2 Th17/Treg Child |
| 基金项目: |
|
| 摘要点击次数: 965 |
| 全文下载次数: 509 |
| 中文摘要: |
| 目的探讨幽门螺杆菌(H.pylori)感染与哮喘发病的影响，分析 H.pylori感染对免疫功能指标、辅助性 T细胞 1(Th1)/辅助性 T细胞 2(Th2)和辅助性 T细胞 17(Th17)/调节 T细胞( Treg)平衡的影响。方法收集 2020年 1月至 2021年 12月，在南阳市第一人民医院接受治疗的哮喘病儿(哮喘组) 142例，及健康儿童(对照组) 120例。采用 14C呼气试验检测 H.pylori感染情况，比较哮喘组和对照组中 H.pylori阳性率。哮喘病儿根据是否合并 H.pylori感染，分为 H.pylori阴性组和 H.pylori阳性组，比较两组间免疫功能指标、 Th1/Th2及 Th17/Treg。结果哮喘组 H.pylori阳性率 10.6%显著低于对照组 32.5%(χ2=19.13，P<0.001)。轻度哮喘组、中度哮喘组和重度哮喘组 H.pylori阳性率分别为 22.2%(10/45)、 6.6%(4/61)和 2.8%(1/36)，三组间比较均差异有统计学意义( χ2=9.82，P=0.007)且重度哮喘组 H.pylori阳性率低于轻度哮喘组( χ2=6.44，P=0.011)。H.pylori阳性组 CD4+、 CD8+免疫球蛋白 M(IgM)和免疫球，蛋白 G(IgG)水平均高于 H.pylori阴性组( P<0.05)。H.pylori阳性组白细胞介素(IL-4)IL-5、 IL-10和、Th2水平低于 H.pylori阴性组， γ干扰素( IFN-γ)、 Th1和 Th1/Th2水平高于 H.pylori阴性组( P<0.05)。 H.pylori阳性组、Treg(5.2±1.3)%和 IL-35(153.9±16.8)ng/L水平高于 H.pylori阴性组 Treg(4.1±1.2)%和 IL-35(135.8±21.4)ng/L，H.pylori阳性组 IL-17水平( 132.4±16.8)ng/L低于 H.pylori阴性组 IL-17水平( 152.3±25.6)ng/L(P<0.05)。结论哮喘病儿 H.pylori阳性率较低， H.pylori阳性可平衡免疫功能、调节 Th1/Th2和 Th17/Treg平衡。 |
| 英文摘要: |
| Objective To explore the effect of Helicobacter pylori (H. pylori) infection on the pathogenesis of asthma, and to analyzethe effect of H. pylori infection on immune function indexes, T helper 1 (Th1)/T helper 2 (Th2) and T helper 17 (Th17)/regulatory T cell(Treg) balance.Methods From January 2020 to December 2021, 142 asthmatic children (asthma group) who were treated in NanyangFirst People's Hospital and 120 healthy control children (control group) were enrolled in the study. H. pylori infection was detected by14C breath test, and the positive rates of H. pylori in asthma group and control group were compared. Children with asthma were as.signed into H. pylori negative group and H. pylori positive group according to whether they were complicated with H. pylori infection.The immune function indexes, Th1/Th2 and Th17/Treg ratios were compared between the two groups.Results The positive rate of H. pylori in the asthma group was significantly lower than that in the control group (10.6% vs. 32.5%, χ2=19.13, P<0.001). The positiverates of H. pylori in mild asthma group, moderate asthma group and severe asthma group were 22.2% (10/45), 6.6% (4/61) and 2.8% (1/36), respectively; the difference among the three groups was found to be statistically significant (χ2=9.82, P=0.007), and the positive rate of H. pylori in the severe asthma group was lower than that of the mild asthma group (χ2=6.44, P=0.011). The levels of CD4+, CD8+, immunoglobulin M (IgM) and immunoglobulin G (IgG) in the H. pylori positive group were higher than those in the H. pylori negativegroup (P<0.05). The levels of Interleukin (IL-4), IL-5, IL-10 and Th2 in the H. pylori positive group were lower than those in the H. py.lori negative group, and the levels of gamma interferon (IFN-γ), Th1 and Th1/Th2 ratio were higher than those in the H. pylori negative group (P<0.05). The levels of Treg and IL-35 in the H. pylori-positive group were higher than those in the H. pylori-negative group [(5.2±1.3) % vs. (4.1±1.2) %, (153.9±16.8) ng/L vs. (135.8±21.4) ng/L], and the level of IL-17 in the H. pylori-positive group was lower than that in the H. pylori-negative group [(132.4±16.8) ng/L vs. (152.3±25.6) ng/L, P<0.05].Conclusion The positive rate of H. pyloriin children with asthma is low, and H. pylori infection can balance immune function, regulate Th1/Th2 and Th17/Treg balance. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
