| 贾春艳,邓宁静,梁平,等.肿瘤病人碘对比剂急性不良反应 33例分析[J].安徽医药,2023,27(12):2542-2544. |
| 肿瘤病人碘对比剂急性不良反应 33例分析 |
| Analysis of 33 cases of acute adverse reaction to iodine contrast media in tumor patients |
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| DOI：10.3969/j.issn.1009-6469.2023.12.045 |
| 中文关键词: 造影剂 药物相关性副作用和不良反应 体层摄影术， X线计算机 碘对比剂 急性不良反应 恶性肿瘤 |
| 英文关键词: Contrast agent Drug-related side effect and adverse reaction Tomography, X-ray computer Iodine contrast Acute adverse reaction Malignant tumor |
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| 中文摘要: |
| 目的探讨恶性肿瘤病人碘对比剂急性不良反应的相关因素及临床特点分析。方法回顾性分析 2018年 5月至 2021年 10月北京市朝阳区三环肿瘤医院行增强 CT的 50 100例恶性肿瘤病人，其中 33例出现碘对比剂急性不良反应，分析其临床特点和相关因素。结果增强 CT检查中碘对比剂急性不良反应的总体发生率为 0.065%(33/50 100)重度不良反应发生率占 0.01%(6/50 100)。女性发生率为 0.096 1%(20/20 804)显著高于男性发生率 0.044 4%(13/29 263)(P<0.，05)。不同年龄组比较， ≤35岁年轻病人易发生急性不良反应( P<0.05)。 33例中既往有食物及药物过敏史 6例，高血压病史 5例。急性不良反应发生时间范围 1~25 min；不良反应症状主要表现为荨麻疹、恶心呕吐、高血压、呼吸困难及过敏性休克等；其中皮肤系统不良反应最高( 60.6%)，其次消化、循环、呼吸系统。给予抗过敏治疗均得到有效控制。结论恶性肿瘤病人在增强 CT检查时，可能会出现不同程度的碘对比剂急性不良反应，女性、年轻病人发生率较高，医护人员对肿瘤病人检查前进行准确评估，严格筛选，提高警惕，确保临床用药安全。 |
| 英文摘要: |
| Objective To investigate the related factors and clinical characteristics of acute adverse reactions to iodine contrast inpatients with malignant tumors.Methods This was a retrospective analysis of 50 100 patients with malignant tumors who underwentenhanced CT at Beijing Sanhuan Cancer Hospital from May 2018 to October 2021, in which 33 patients developed acute adverse reac.tions to iodine contrast, and the clinical characteristics and related factors of the patients with adverse reactions were analyzed. Re. sults The overall incidence of acute adverse reactions of enhanced CT was 0.065% (33/50 100), and the incidence of severe adversereactions was 0.01% (6/50 100). The incidence was 0.096 1% (20/20 804) in females, and 0.044 4% (13/29 263) in males, which wassignificantly higher (P<0.05). Comparing different age groups, young patients under 35 years old were prone to acute adverse reactions (P<0.05). Among the 33 patients, there was a history of previous food and drug allergy in 6 cases, and a history of hypertension in 5 cas.es. The time range of acute adverse reactions to iodine contrast agents was 1-25 min. The symptoms of adverse reactions mainly mani.fested as urticaria, nausea and vomiting, hypertension, dyspnea and anaphylactic shock. The adverse reaction of the skin system wasthe highest (60.6%), followed by the digestive, circulatory and respiratory systems. Antiallergic treatment was effectively controlled.Conclusions Malignant tumor patients may have adverse reactions to varying degrees when enhancing CT, and the incidence is high.er in female and young patients. Medical staff should accurately evaluate tumor patients before examination, strictly screen them, andbe more vigilant to ensure the safety of clinical medication. |
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