| 张永强,李展展,段静,等.能谱 CT联合 VEGF预测 120例肝癌 TACE术后碘油沉积[J].安徽医药,2024,28(4):714-718. |
| 能谱 CT联合 VEGF预测 120例肝癌 TACE术后碘油沉积 |
| Application of spectral CT combined with VEGF in predicting lipiodol deposition afterTACE for 120 cases of liver cancer |
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| DOI：10.3969/j.issn.1009-6469.2024.04.016 |
| 中文关键词: 肝肿瘤 经导管肝动脉化疗栓塞术 能谱 CT 血管内皮生长因子 碘油沉积 |
| 英文关键词: Liver neoplasms Transcatheter hepatic arterial chemoembolization Spectral CT Vascular endothelial growth fac?tor Lipiodol deposition |
| 基金项目:三门峡市 2021年科技发展计划项目( 2021004034) |
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| 中文摘要: |
| 目的探究能谱 CT定量分析联合血清血管内皮生长因子( VEGF)水平检测在肝癌经导管肝动脉化疗栓塞术( TACE)后碘油沉积中的预测价值。方法收集 2020年 1月至 2022年 3月三门峡市中心医院行 TACE术的 120例肝癌病人作为研究对象，并将其分为 A组( TACE术后碘油沉积面积 >50%)和 B组( TACE术后碘油沉积面积 ≤50%)；同时分为 C组( TACE术后碘油沉积区)和 D组( TACE术后无碘油沉积区)。采用能谱 CT检测肝癌病人 TACE术前碘浓度及术后碘油沉积情况，计算动脉期标准化碘浓度( ANIC)、静脉期标准化碘浓度( VNIC)、肝脏标准化碘浓度比率( ICratio，ICratio=ANIC/VNIC)采用酶联免疫吸附法检测血清 VEGF水平；绘制 ROC曲线分析术前碘浓度及血清 VEGF水平预测肝癌 TACE术后碘油沉积情况，的价值；采用多因素 logistic回归分析肝癌 TACE术后碘油沉积情况的影响因素。结果 B组与 A组肿瘤分期 Ⅲ+Ⅳ期( 60.29%比 19.23%)、组织低分化( 47.06%比 23.08%)、血管侵犯( 63.24%比 11.54%)比例及 ANIC(0.18±0.06比 0.26±0.08)、 VNIC(0.40±0.10比 0.54±0.12)、血清VEGF［(284.56±78.17)ng/L比( 225.74±61.05)ng/L］水平差异有统计学意义( P<0.05)。 VEGF、组织分化程度是肝癌 TACE术后 1个月碘油沉积面积 ≤50%的影响因素( P<0.05)。 D组与 C组 ANIC(0.15±0.04比 0.24±0.07)、 VNIC(0.44±0.09比0.53±0.10)、 ICratio(0.34±0.08比 0.45±0.09)差异有统计学意义( P<0.05)。结论能谱 CT定量分析联合血清 VEGF水平检测可较好地预测肝癌 TACE术后碘油沉积情况。 |
| 英文摘要: |
| Objective To explore the predictive value of spectral CT quantitative analysis combined with serum vascular endothelialgrowth factor (VEGF) detection for lipiodol deposition after transcatheter arterial chemoembolization (TACE) for liver cancer. Meth? ods A total of 120 patients with liver cancer who underwent TACE in Sanmenxia Central Hospital from January 2020 to March 2022were enrolled and assigned into group A (area of lipiodol deposition after TACE >50%) and group B (area of lipiodol deposition afterTACE ≤50%); meanwhile, they were assigned into group C (with lipiodol deposition after TACE) and group D (without lipiodol deposi?tion after TACE). Spectral CT was used to detect preoperative iodine concentration and postoperative lipiodol deposition in patientswith liver cancer undergoing TACE, and the arterial-phase normalized iodine concentration (ANIC), the venous-phase normalized io? dine concentration (VNIC) and the liver-normalized iodine concentration ratio (ICratio, ICratio=ANIC/VNIC) were calculated; ELISAwas used to detect serum VEGF level. ROC curve was drawn to analyze the value of preoperative iodine concentration and serum VEGFlevel in predicting lipiodol deposition after TACE for liver cancer; multivariate logistic regression was used to analyze the influencingfactors of lipiodol deposition after TACE for liver cancer.Results There were statistically significant differences between group B and group A in cancer staging Ⅲ+Ⅳ (60.29% vs. 19.23%), poor differentiation (47.06% vs. 23.08%), vascular invasion ratio (63.24% vs. 11.54%), and levels of ANIC (0.18±0.06 vs. 0.26±0.08), VNIC (0.40±0.10 vs. 0.54±0.12), and serum VEGF [(284.56±78.17) ng/L vs. (225.74±61.05) ng/L] (P<0.05). VEGF and histological differentiation were the influencing factors for area of lipiodol deposition ≤50% at 1 month after TACE for liver cancer (P<0.05). There were statistically significant differences in ANIC (0.15±0.04 vs. 0.24±0.07), VN? IC (0.44±0.09 vs. 0.53±0.10) and ICratio (0.34±0.08 vs. 0.45±0.09) between group D and group C (P<0.05).Conclusion Spectral CTquantitative analysis combined with serum VEGF detection can better predict the lipiodol deposition after TACE for liver cancer. |
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