| 黄亚晓,何新雨,曾小娟,等.NOD样受体蛋白 3炎症小体在多柔比星诱导心脏毒性中的意义[J].安徽医药,2024,28(5):860-864. |
| NOD样受体蛋白 3炎症小体在多柔比星诱导心脏毒性中的意义 |
| Significance of NLRP3 inflammasome in doxorubicin-induced cardiactoxicity |
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| DOI：10.3969/j.issn.1009-6469.2024.05.003 |
| 中文关键词: 多柔比星 NOD样受体蛋白 3 心脏毒性 |
| 英文关键词: Doxorubicin NOD-like receptor protein 3 Cardiotoxicity |
| 基金项目:兰州大学第一医院院内基金资助项目( ldyyn2018-39) |
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| 中文摘要: |
| 晚期肿瘤病人的生命周期因新药的出现不断延长，同时，抗肿瘤药物所致的毒副作用也受到重视。多柔比星( DOX)作为强大的广谱抗肿瘤药物虽极大地延长了肿瘤病人的生存周期，但其诱导的剂量相关性的心脏毒性限制了其临床应用。 NOD样受体蛋白 3(NLRP3)炎症小体在 DOX诱导的心脏毒性( DIC)的炎症过程发挥着重要作用，且一些炎症小体抑制剂还可减轻 DIC。该文根据近 5年的最新进展，围绕 NLRP3炎症小体参与 DIC的作用及机制等做一归纳、总结。 |
| 英文摘要: |
| The life cycle of patients with advanced tumors has been prolonged due to the emergence of new drugs, while meanwhilethe side effects of anti-tumor drugs have also been paid attention to. Doxorubicin (DOX), as a powerful broad-spectrum anti-tumor drug, has greatly prolonged the life cycle of tumor patients, but its clinical application is limited by dose-dependent cardiotoxicity. NOD likereceptor protein 3 (NLRP3) inflammasome plays an important role in the inflammatory process of DOX-induced cardiotoxicity (DIC),and some inhibitors of inflammasome can reduce DIC. Based on the latest research progress in the past 5 years, this article summarizedhow the NLRP3 inflammasome involves in DIC. |
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