| 张晓彤,郝婧婧,李芳,等.长链的非编码 RNA生长停滞特异性转录本 5在骨关节炎中的研究进展[J].安徽医药,2024,28(5):870-873. |
| 长链的非编码 RNA生长停滞特异性转录本 5在骨关节炎中的研究进展 |
| Research progress of LncRNA GAS5 in osteoarthritis |
| |
| DOI：10.3969/j.issn.1009-6469.2024.05.005 |
| 中文关键词: 骨关节炎 长链非编码 RNA 生长停滞特异性转录本 5 |
| 英文关键词: Osteoarthritis Long noncoding RNA Growth arrest-specific 5 |
| 基金项目:山西省归国留学人员科研基金(晋财社〔 2018〕123号)；山西省华晋骨科公益基金( 20210401) |
|
| 摘要点击次数: 80 |
| 全文下载次数: 40 |
| 中文摘要: |
| 骨关节炎( OA)是一种以软骨退变、骨重建为主要病理特点的慢性关节疾病。目前没有可治愈该疾病的药物及手段，疗策略有限的根本原因是对其潜在发病机制的认识不足。长链的非编码 RNA(LncRNAs)被认为是许多疾病中的一类新的调治控因子，是目前研究 OA发病机制的一个重要切入点。 LncRNA生长停滞特异性转录本 5(Cas5)参与调控细胞的增殖、分化及凋亡，是一种在软骨细胞中特异性高表达的 LncRNA。然而，由于 LncRNA Cas5作用机制复杂，其与 OA相关具体分子机制目前仍不明确。该文针对 LncRNA Cas5在 OA中的软骨细胞凋亡、软骨基质代谢成骨分化及治疗方面的作用进行综述。 |
| 英文摘要: |
| Osteoarthritis (OA) is a chronic joint disease with cartilage degeneration and bone reconstruction as its main pathologic fea-tures. At present, there are no drugs and means to cure the disease, and the primary cause of the limited treatment strategies is the in-sufficient understanding of the underlying pathogenesis. Long non-coding RNAs (LncRNAs) are considered as a new class of regulatorsfor many diseases and an important point for studying the pathogenesis of OA. LncRNA growth arrest specific transcript 5 (GAS5) is in-volved in the regulation of cell proliferation, differentiation and apoptosis, and is an LncRNA specifically and highly expressed in chon-drocytes. However, due to the complex mechanism of LncRNA GAS5, the specific molecular mechanism associated with osteoarthritisis still unclear. This review addressed the role of LncRNA GAS5 in chondrocyte apoptosis, the metabolism and osteogenic differentia-tion of cartilage matrix, and its treatment. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
