| 刘莉,王凤荣.基于网络药理学和分子对接法研究参七解郁方治疗双心疾病的分子机制[J].安徽医药,2024,28(5):909-914. |
| 基于网络药理学和分子对接法研究参七解郁方治疗双心疾病的分子机制 |
| Molecular mechanism of Shenqi Jieyu prescription in the treatment of psycho-cardiological disease based on network pharmacology and molecular docking |
| |
| DOI：10.3969/j.issn.1009-6469.2024.05.013 |
| 中文关键词: 冠心病 焦虑 抑郁 双心疾病 参七解郁方 网络药理学 分子对接 |
| 英文关键词: Coronary heart disease Anxiety Depression Psycho-cardiological disease Shenqi Jieyu prescription Network pharmacology Molecular docking |
| 基金项目: |
|
| 摘要点击次数: 60 |
| 全文下载次数: 45 |
| 中文摘要: |
| 目的通过网络药理学与分子对接法研究参七解郁方治疗双心疾病的潜在有效成分和作用通路。方法通过中药系统药理学数据库分析平台 TCMSP和 TCMID数据库查找该方所用药物的活性成分以及作用靶标，在 Gene Cards数据库下载双心疾病靶点；以 String平台数据为基础，利用 Cytoscape软件构建参七解郁方与双心疾病共同靶点的蛋白质 -蛋白质相互作用网络( PPI)；绘制“活性成分 -靶点 -通路”网络图；采用 Auto Dock Tools工具进一步对接药物活性成分及可能作用的靶点。结果参七解郁方有 89个主要活性成分， 56个主要靶点，与 30个信号通路有关。将度值大于5的前 7个活性成分的分子配体与前5个靶点进行分子对接，结果显示活性成分与靶点分子对接能力均较好。结论参七解郁方通过多成分、多靶点、多通路参与双心疾病的治疗。 |
| 英文摘要: |
| Objective To study the active ingredients and mechanism of Shenqi Jieyu prescription in the treatment of psycho-cardio-logical disease based on network pharmacology and molecular docking.Methods The active compounds and predicted targets of Shen. qi Jieyu prescription were collected from TCMSP and TCMID database. Psycho-cardiological disease targets were downloaded on the GeneCards website.We used Cytoscape software to construct protein-protein interaction (PPI) network of common targets for drugs and psycho-cardiological disease based on the data of String platform. The network of "active compounds-target-pathways" was established and Auto Dock Tools software was used for verification of active compounds and potential targets.Results Shenqi Jieyu prescriptionconsisted of 89 major active compounds,56 major targets and was related with 30 signaling pathways.Molecular docking results showedthat the top 7 active ingredients with a degree value greater than 5 were well docked with the top 5 targets.Conclusion Shenqi Jieyu prescription participates in the treatment of psycho-cardiological disease through multicomponents,multi-targets and multi-pathways. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
