| 陈明长,高伟明,胡文彬.A型肉毒毒素、乙醇肌内局部注射联合局部封闭治疗痉挛性斜颈 14例[J].安徽医药,2024,28(5):992-998. |
| A型肉毒毒素、乙醇肌内局部注射联合局部封闭治疗痉挛性斜颈 14例 |
| Botulinum toxin A combined with muscle alcohol block and local blocking in the treatment of 14 cases of spasmodic torticollis |
| |
| DOI：10.3969/j.issn.1009-6469.2024.05.031 |
| 中文关键词: 斜颈 A型肉毒毒素 肌内乙醇阻滞 局部封闭 疗效 |
| 英文关键词: Torticollis Botulinum toxin type A Muscle alcohol block Local block Efficacy |
| 基金项目: |
|
| 摘要点击次数: 72 |
| 全文下载次数: 45 |
| 中文摘要: |
| 目的分析颈项部肌内局部注射 A型肉毒毒素( BTX-A)、肌内乙醇阻滞( MAB)和局部封闭联合方案治疗痉挛性斜颈的临床特点、疗效、预后以及长期随访。方法回顾性分析 2004年 5月至 2021年 10月在安徽中医药大学神经病学研究所附属医院就诊，明确诊断为痉挛性斜颈并采用 BTX-A、MAB以及封闭疗法联合治疗的病人的临床资料，在治疗前后行 Tsui量表、全面肌张力障碍量表( FMRS)评估疗效，出院后进行长期随访调查和 36项简明健康问卷调查( SF-36)。按随访结果将病人分为症状复发组和症状未复发组，比较各临床因素同临床结果之间的关系。结果 14例病人中，男性 4例，女性 10例，年龄范围为 18~47岁。 Tsui量表治疗前为(11.86±4.37)分，治疗后为( 1.07±0.92)分，治疗后评分显著降低( P<0.01)； Tsui量表提示 13例病人症状为完全缓解， 1例为明显缓解。 FMRS治疗前为( 8.21±3.62)分；治疗后为( 0.89±0.86)分，治疗后评分显著降低( P<0.01)。随访结果表明 14例病人中 4例长期随访至今未曾复发； 6例复发，疗效维持时间均 >14个月； 4例随访丢失。病人出院半年后进行 SF-36健康状况问卷调查，显示随访到的 10例病人 9项得分均 >80.3分，提示生命质量较高，预后较好。按随访结果分组，两组年龄、性别、病程、身体质量指数( BMI)、临床分型、 BTX-A剂量、 BTX-A注射次数、封闭次数比较，差异无统计学意义( P> 0.05)；两组治疗前 Tsui评分、 MAB注射次数比较，差异有统计学意义( P<0.05)。结论 BTX-A、MAB联合局部封闭疗法治疗痉挛性斜颈病人疗效显著，维持时间较长，未见明显并发症，值得临床上进一步扩大样本量进行对比分析等系列研究与推广应用。 |
| 英文摘要: |
| Objective To analyze the clinical characteristics, efficacy, prognosis, and long-term follow-up of local injection of botuli-num toxin type A (BTX-A), muscle alcohol block (MAB) and local blocking combined regimen into the nuchal muscles in the treatment of spasmodic torticollis.Methods The clinical data of patients with spasmodic torticollis who were diagnosed as spasmodic torticollis and treated with BTX-A, MAB, and blocking therapy in the Affiliated Hospital of Institute of Neurology, Anhui University of TraditionalChinese Medicine from May 2004 to October 2021 were retrospectively analyzed. The Tsui scale and Fahn Marsden Rating Scale(FMRS) were performed before and after treatment to assess efficacy. A long-term follow-up survey and 36-item Short-From-36 Health Survey (SF-36) were performed after discharge. According to the follow-up results, the patients were assigned into the symptom recur-rence group and symptom non-recurrence group to compare the relationship between each clinical factor and clinical results.Results Of the 14 patients, 4 were male and 10 were female, aged 18-47 years. The mean score on the Tsui scale was (11.86 ± 4.37) points be-fore treatment and (1.07 ± 0.92) points after treatment, and the score was significantly reduced after treatment (P<0.01); the Tsui scalerevealed complete remission of symptoms in 13 patients and significant remission in 1 patient. The mean score of FMRS was (8.21 ±3.62) points before treatment and (0.89±0.86) points after treatment, and the score significantly decreased after treatment (P<0.01). The follow-up results showed that 4 of 14 patients had no recurrence after long-term follow-up, 6 patients had a recurrence, and the duration of efficacy was more than 14 months; 4 patients were lost during follow-up. Six months after discharge, the SF-36 health status question-naire showed that the scores of 9 items of 10 patients were more than 80.3 points, indicating higher quality of life and better prognosis. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
