文章摘要
王泽帅,赵世龙,刘秋红,等.急性缺血性脑卒中病人血清降钙素原、白细胞介素 -33及 25-羟维生素 D水平与卒中相关性肺炎的关系研究[J].安徽医药,2024,28(6):1120-1123.
急性缺血性脑卒中病人血清降钙素原、白细胞介素 -33及 25-羟维生素 D水平与卒中相关性肺炎的关系研究
Relationships between serum PCT, IL-33 and 25-(OH)D levels and stroke-associated pneumonia in patients with acute ischemic stroke
  
DOI:10.3969/j.issn.1009-6469.2024.06.013
中文关键词: 脑梗死  卒中  卒中相关性肺炎  降钙素原  白细胞介素 -33  25-羟维生素 D
英文关键词: Brain infarction  Stroke  Stroke-associated pneumonia  Procalcitonin  Interleukin-33  25-Hydroxyvitamin D
基金项目:2020年度河南省医学科技攻关计划项目( LHGJ20200772)
作者单位
王泽帅 郑州大学第一附属医院呼吸与危重症医学科河南郑州 450052 
赵世龙 郑州大学第一附属医院呼吸与危重症医学科河南郑州 450052 
刘秋红 郑州大学第一附属医院呼吸与危重症医学科河南郑州 450052 
高延秋 郑州市中心医院重症医学科河南郑州 450007 
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中文摘要:
      目的探讨急性缺血性脑卒中( AIS)病人血清降钙素原(PCT)、白细胞介素 -33(IL-33)、 25-羟维生素 D[25(-OH)]D水平与卒中相关性肺炎( SAP)的关系。方法选取 2020年 5月至 2022年 4月郑州大学第一附属医院重症监护病区 AIS病人 200例,根据入重症监护病区 72 h内是否发生 SAP分为 SAP组( 78例)与非 SAP组( 122例)。统计并比较两组一般资料[性别、龄、身体质量指数( BMI)、高血压、高脂血症]以及血清 PCT、IL-33、25-水年入院时格拉斯哥昏迷量表( GCS)评分、糖尿病、(OH)D平。采用 logistic回归分析 AIS病人并发 SAP的影响因素,受试者操作特征曲线( ROC曲线)分析血清 PCT、IL-33及 25-(OH)D及联合检测对 SAP的诊断效能。结果 SAP组血清 25-血清 PCT、 均差异(OH)D水平低于非 SAP组,IL-33水平高于非 SAP组,有统计学意义( P<0.05); logistic回归分析显示 PCT、 25-ROC曲线显示IL-33、(OH)D是 AIS病人并发 SAP的影响因素( P<0.05); 血清 PCT、IL-33、25-(OH)D及联合检测 AIS病人并发 SAP的 AUC分别为 0.93[95%CI:(0.89,0.96)]、 0.93[95%CI:(0.89,0.96)]、 0.90[95%CI:(0.85,0.93)]、 0.99[95%CI:(0.97,1.00)],联合检测时预测效能较高。结论血清 PCT、IL-33、25-(OH)D水平对 AIS病人并发 SAP具有早期诊断价值,联合检测可提高 SAP的诊断效能。
英文摘要:
      Objective To investigate the relationships between serum levels of procalcitonin (PCT), interleukin-33 (IL-33), and 25hydroxyvitamin D (25-(OH)D) and stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS).Methods A total of 200 AIS patients from May 2020 to April 2022 were selected from the intensive care wards of the First Affiliated Hospital of Zhengzhou University and divided into the SAP group (78 patients) and the non-SAP group (122 patients) according to whether SAP occurredwithin 72 h of admission to the intensive care ward. The general information [sex, age, body mass index (BMI), Glasgow Coma Scale(GCS) score on admission, hypertension status, diabetes status, hyperlipidemia status] and serum PCT, IL-33, and25-(OH)D levels ofthe two groups were statistically and comparatively analyzed. Logistic regression was used to analyze the influencing factors of AIS patients complicated with concurrent SAP, and receiver operating characteristic (ROC) curves were used to analyze the diagnostic efficacyof serum PCT, IL-33 and 25-(OH)D and the combined detection of SAP.Results The serum 25-(OH)D level in the SAP group was low er than that in the non-SAP group, and the serum PCT and IL-33 levels were significantly greater than those in the non-SAP group, and all the difference were statistically significant (P<0.05). Logistic regression revealed showed that PCT, IL-33 and 25-(OH)D were the in fluencing factors for AIS patients complicated with SAP (P<0.05). ROC curves showed that the AUCs of serum PCT, IL-33, and 25-(OH) D and the combined detection of AIS patients complicated with SAP were 0.93 [95% CI: (0.89, 0.96)], 0.93 [95% CI: (0.89, 0.96)], 0.90 [95% CI: (0.85, 0.93)], and 0.99 [95% CI: (0.97, 1.00)], respectively, and the predictive efficacy was greater with combined detection. Conclusion The serum PCT, IL-33 and 25-(OH)D levels have early diagnostic value in AIS patients complicated with SAP, and thecombined detection can improve the diagnostic efficacy of SAP.
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