文章摘要
倪南鹰,裴永红,张永,等.孕早期血清半乳糖凝集素 3、微RNA-29a对孕妇发生妊娠糖尿病风险的预测价值分析[J].安徽医药,2024,28(6):1135-1138.
孕早期血清半乳糖凝集素 3、微RNA-29a对孕妇发生妊娠糖尿病风险的预测价值分析
Analysis of the predictive value of serum Gal-3 and miR-29a in early pregnancy for the risk of gestational diabetes mellitus in pregnant women
  
DOI:10.3969/j.issn.1009-6469.2024.06.016
中文关键词: 糖尿病,妊娠  微 RNA-29a  半乳糖凝集素 3  孕早期  联合检测
英文关键词: Diabetes, gestational  MiR-29a  Galectin 3  Early pregnancy  Combined detection
基金项目:江苏省高层次卫生人才“六个一工程”拔尖人才科研项目( LGY2017040)
作者单位E-mail
倪南鹰 东部战区总医院妇产科江苏南京 210002  
裴永红 东部战区总医院妇产科江苏南京 210002  
张永 东部战区总医院妇产科江苏南京 210002 yi3240951@163.com 
李海波 南通市妇幼保健院检验科江苏南通 226006  
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中文摘要:
      目的分析孕早期血清半乳糖凝集素 3(Gal-3)、微 RNA(miR)-29a对孕妇发生妊娠糖尿病( GDM)风险的预测价值。方法选取 2021年 3月至 2022年 3月在东部战区总医院进行围生期检查的 60例 GDM病人作为 GDM组,同期体检健康的孕妇 60例作为对照组。抽取病人空腹静脉血,检测并比较两组间病人孕早期血清 Gal-3(以酶联免疫吸附测定检测)、 miR-29a(PCR法)表达水平。绘制受试者操作特征曲线( ROC曲线)评估孕早期血清 Gal-3、miR-29a水平预测孕妇发生 GDM风险的价值,多因素 logistic回归分析影响孕妇发生 GDM的因素。结果 GDM组血清低密度脂蛋白胆固醇( LDL-C)、 Gal-3[( 40.31±4.12)行μg/L比( 35.79±3.58)μg/L]、糖化血红蛋白( HbA1c)、服糖后 2h血糖( 2 hPG)、空腹血糖( FPG)、胰岛素抵抗指数( HOMA-IR)水平均明显高于对照组( P<0.05),空腹胰岛素( FINS)、 miR-29a(26.78±2.72比 30.46±3.09)水平明显低于对照组( P<0.05);绘制 ROC曲线评估血清 Gal-3、miR-29a水平预测 GDM发生的价值显示,单独检测时, Gal-3的特异度 86.67%最高, miR-29a的灵敏度 90.00%最高,两者联合检测灵敏度、特异度均处于较高水平( 95.00%、88.33%)。行多因素 logistic回归分析显示,血清 Gal-3、 miR-29a、HOMA-IR、HbA1c为 GDM发生的影响因素( P<0.05)。结论 GDM病人孕早期血清 Gal-3水平较高、 miR-29a水平较低,可能为预测 GDM发生的潜在指标,两者联合检测价值更高。
英文摘要:
      Objective To analyze the predictive value of serum galectin 3 (Gal-3) and microRNA (miR)-29a in early pregnancy for the risk of gestational diabetes mellitus (GDM) in pregnant women.Methods Sixty patients with GDM who underwent perinatal examination at the General Hospital of Eastern Command from March 2021 to March 2022 were enrolled in the GDM group, and 60 pregnantwomen who were physically healthy during the same period were enrolled in the control group. Fasting venous blood was drawn fromthe patients, and serum Gal-3 (detected by enzyme-linked immunosorbent assay) and miR-29a (PCR method) expression levels in earlypregnancy were detected and compared between the two groups. Receiver operating characteristic (ROC) curves were plotted to evaluate the value of serum Gal-3 and miR-29a levels in early pregnancy in predicting the risk of GDM in pregnant women, and multivariatelogistic regression was performed to analyze the factors affecting the occurrence of GDM in pregnant women.Results The serum levels of low-density lipoprotein cholesterol (LDL-C), Gal-3 [(40.31±4.12) μg/L vs. (35.79±3.58) μg/L], glycated hemoglobin A1c (HbA1c), 2-h postglycemic (2 hPG), fasting plasma glucose (FPG), and the index of insulin resistance index (HOMA-IR) in the GDM group were sig nificantly greater than those in the control group (P<0.05), and the levels of fasting insulin (FINS) and miR-29a (26.78±2.72 vs. 30.46± 3.09) were significantly lower in the GDM group than in the control group (P<0.05). ROC curve analysis of the ability of serum Gal-3 and miR-29a levels to predict the occurrence of GDM revealed that Gal-3 had the highest specificity of (86.67%) and that miR-29a had the highest sensitivity (90.00%) when detected alone, and the sensitivity and specificity of these two parameters were at a high level inthe combined assay (95.00% and 88.33%, respectively). Multivariate logistic regression analysis revealed that serum Gal-3, miR-29a, HOMA-IR, and HbA1c were the influencing factors for the occurrence of GDM (P<0.05).Conclusion Patients with GDM had high levels of serum Gal-3 and low levels of miR-29a in early pregnancy, which may be potential indicators for predicting the occurrence ofGDM, and the combined detection value of the two is relatively high.
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