文章摘要
张顺礼,王雅琪,胡继卫,等.微 RNA-454-3p、FERM结构域蛋白 6在乳腺癌组织中的表达水平及临床意义[J].安徽医药,2024,28(6):1161-1164.
微 RNA-454-3p、FERM结构域蛋白 6在乳腺癌组织中的表达水平及临床意义
Expression levels and clinical significance of miR-454-3p and FRMD6 in breast cancer tissues
  
DOI:10.3969/j.issn.1009-6469.2024.06.022
中文关键词: 乳腺肿瘤  微 RNA-454-3p  FERM结构域蛋白 6  预后  临床意义
英文关键词: Breast neoplasms  MiR-454-3p  FERM domain protein 6  Prognosis  Clinical significance
基金项目:河北省卫生和计划生育委员会科研基金项目( 20160874)
作者单位
张顺礼 唐山市人民医院乳腺外科河北唐山 063001 
王雅琪 唐山市人民医院乳腺外科河北唐山 063001 
胡继卫 唐山市人民医院乳腺外科河北唐山 063001 
马杰 唐山市人民医院乳腺外科河北唐山 063001 
张景华 唐山市人民医院乳腺外科河北唐山 063001 
谷峥 唐山市人民医院乳腺外科河北唐山 063001 
王宇 唐山市人民医院乳腺外科河北唐山 063001 
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中文摘要:
      目的探讨微 RNA(miR)-454-3p、FERM结构域蛋白 6(FRMD6)在乳腺癌组织中的表达水平以及临床意义。方法选取唐山市人民医院 2016年 12月至 2018年 12月住院手术的 150例乳腺癌病人术中切除的乳腺癌组织标本及癌旁组织标本;用实时荧光定量逆转录聚合酶链反应( qRT-PCR)检测 miR-454-3p、FRMD6在组织中的水平;采用 Kaplan-Meier法分析 miR采454-3p、FRMD6水平与乳腺癌病人预后的关系,并用 log-rank法进行检验; Cox回归分析影响乳腺癌病人预后的因素。结果乳腺癌组织 miR-454-3p水平( 1.25±0.24)高于癌旁组织( 0.99±0.22),FRMD6水平( 0.79±0.19)低于癌旁组织( 1.01±0.24),差异有统计学意义( P<0.05);癌组织中 miR-454-3p、FRMD6水平与淋巴结转移、组织分化以及 TNM分期有关( P<0.05); miR-454-3p高表达组和 FRMD6低表达组病人 3年累积生存率分别低于 miR-454-3p低表达组和 FRMD6高表达组病人(均 P<0.05); miR-454-3p高表达、 FRMD6低表达、 TNM分期为 Ⅲ/Ⅳ期、淋巴结转移是影响乳腺癌病人预后的危险因素( P<0.05)。结论 miR-454-3p在乳腺癌组织中表达上调, FRMD6在乳腺癌组织中表达降低,二者与乳腺癌病人预后密切相关,有望成为临床上预测乳腺癌病人预后的生物性标志物。
英文摘要:
      Objective To investigate the expression levels and clinical significance of miR-454-3p and FERM domain protein 6 (FR MD6) in breast cancer tissues.Methods The breast cancer tissue specimens and adjacent tissue specimens were collected from 150breast cancer patients who were hospitalized and operated in Tangshan people's Hospital from December 2016 to December 2018; real-time fluorescence quantitative PCR (qRT-PCR) was applied to detect the expression levels of miR-454-3p and FRMD6 in tissues; Ka plan-Meier method was applied to analyze the relationship between the levels of miR-454-3p and FRMD6 and the prognosis of breast cancer patients,the log-rank method was used to test; Cox regression was applied to analyze the factors affecting the prognosis of breastcancer patients. Pearson correlation was applied to analyze the miR-454-3p and FRMD6 levels in breast cancer tissues.Results The level of miR-454-3p in breast cancer tissue (1.25±0.24) was higher than that in adjacent tissue (0.99±0.22), and the level of FRMD6(0.79±0.19) was lower than that in adjacent tissue (1.01±0.24) (P<0.05); the levels of miR-454-3p and FRMD6 in breast cancer tissue were related to lymph node metastasis, tissue differentiation and TNM stage (P<0.05); the 3-year cumulative survival rate of patients with high miR-454-3p expression group and low FRMD6 expression group was obviously lower than that of patients with low miR-4543p expression group and high FRMD6 expression group, respectively (P<0.05); high expression of miR-454-3p, low expression of FRMD6, TNM stage Ⅲ/Ⅳ, and lymph node metastasis were risk factors affecting the prognosis of breast cancer patients (P<0.05).Conclu sions The expression of miR-454-3p is up-regulated in breast cancer tissue, and the expression of FRMD6 is down-regulated inbreast cancer tissue. The two are closely related to the prognosis of breast cancer patients and are expected to be clinical biomarkers forpredicting the prognosis of breast cancer patients.
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