文章摘要
孟令华,位庚,常湛,等.血清可溶性 CD36、抵抗素、能量平衡相关蛋白联合预测 2型糖尿病合并非酒精性脂肪性肝病的价值探讨[J].安徽医药,2024,28(6):1165-1169.
血清可溶性 CD36、抵抗素、能量平衡相关蛋白联合预测 2型糖尿病合并非酒精性脂肪性肝病的价值探讨
The value of serum soluble CD36, resistin, and energy balance-related protein in combination to predict type 2 diabetes mellitus combined with nonalcoholic fatty liver disease
  
DOI:10.3969/j.issn.1009-6469.2024.06.023
中文关键词: 糖尿病, 2型  非酒精性脂肪性肝病  可溶性 CD36  抵抗素  能量平衡相关蛋白 的,
英文关键词: Diabetes mellitus, type 2  Nonalcoholic fatty liver disease  Soluble CD36  Resistin  Adropin
基金项目:2020年度河北省医学科学研究重点课题计划项目( 20201351)
作者单位
孟令华 石家庄市第二医院 消化内科河北石家庄 050051 
位庚 石家庄市第二医院糖尿病中医科河北石家庄 050051 
常湛 石家庄市第二医院糖尿病中医科河北石家庄 050051 
赵永晓 石家庄市第二医院 消化内科河北石家庄 050051 
刘红利 石家庄市第二医院糖尿病中医科河北石家庄 050051 
摘要点击次数: 73
全文下载次数: 57
中文摘要:
      目的探讨血清可溶性 CD36(sCD36)、抵抗素、能量平衡相关蛋白(Adropin)联合对 2型糖尿病(T2DM)合并非酒精性脂肪性肝病( NAFLD)的预测价值。方法前瞻性选取石家庄市第二医院 2018年 5月至 2021年 5月收治的 90例 T2DM合并 NAFLD病人( A组)、 90例单纯 T2DM病人( B组)同期选取 90例体检健康者(对照组)作为研究对象。通过酶联免疫吸附测定检测研究对象血清 sCD36、抵抗素、 Adropin表达水,平,对比分析三组 sCD36、抵抗素、 Adropin表达水平差异;分析 sCD36、抵抗素、 Adropin表达相关性; logistic回归分析 T2DM合并 NAFLD的影响因素;受试者操作特征曲线( ROC曲线)分析 sCD36、抵抗素、 Adropin三者联合对 T2DM合并 NAFLD的预测价值。结果 A组病人血清 sCD36(63.7±15.6)ng/L、抵抗素( 3.15±0.46)μg/L水平均高于 B组[( 43.8±14.2)ng/L、(2.72±0.68)μg/L]和对照组[( 22.9±5.7)ng/L、(2.58±0.39)μg/L](P<0.05),血清 Adropin水平(66.28±27.62)ng/L均低于 B组( 86.73±25.46)ng/L和对照组( 128.59±45.22)ng/L,差异有统计学意义( P<0.05)。 sCD36与抵抗素表达水平呈正相关(r=0.29,P<0.05)Adropin与 sCD36表达呈负相关(r=0.57,P<0.05)。 logistic回归分析显示, sCD36,抵抗素,总胆固醇( TC)是 T2DM合并 NAFLD影响因素( P<0.05)。 ROC曲线分析显示, sCD36、抵抗素、 Adropin单独及三者联合预测 T2DM合并 NAFLD的曲线下面积( AUC)分别为 0.81、0.74、0.72、0.89,三者联合对 T2DM合并 NAFLD的预测效能显著高于单指标独立预测( P<0.05)。结论 T2DM合并 NAFLD病人血清 sCD36、抵抗素水平升高, Adropin水平降低,三者联合对预测 T2DM合并 NAFLD具有较高效能。
英文摘要:
      Objective To investigate the predictive value of serum soluble CD36 (sCD36), resistin, and energy balance-associated protein (Adropin) combined with type 2 diabetes mellitus (T2DM) in patients with nonalcoholic fatty liver disease (NAFLD).Methods A total of 90 patients with T2DM and NAFLD (group A) and 90 patients with T2DM alone (group B) admitted to the Second Hospital ofShijiazhuang City from May 2018 to May 2021 were prospectively selected, and 90 physically examined healthy people (control group)were selected as study subjects during the same period. The serum sCD36, resistin and adropin expression levels of the study subjectswere detected by enzyme-linked immunosorbent assay, and the differences in the expression levels of sCD36, resistin and adropinamong the three groups were compared and analyzed. The correlations between the expression of sCD36, resistin and adropin were analyzed; logistic regression was used to analyze the influencing the combination of T2DM and NAFLD; and the receiver operating characteristic (ROC) curves were used to analyze the predictive value of the combination of sCD36, resistin and adropin on the prognosis of patients with T2DM combined with NAFLD.Results The serum levels of sCD36 (63.7±15.6) ng/L and resistin (3.15±0.46) μg/L weregreater in patients in group A than in the group B [(43.8±14.2) ng/L, (2.72±0.68) μg/L] and in the control group [(22.9±5.7) ng/L, (2.58±0.39) μg/L] (P<0.05). The serum adropin concentration [(66.28±27.62) ng/L] was significantly lower than that in group B [(86.73±25.46) ng/L] and the control group [(128.59±45.22) ng/L], and the differences were statistically significant (P<0.05). sCD36 was posi tively correlated with the expression level of resistin (r=0.29, P<0.05), and adropin was negatively correlated with the expression of sCD36 (r=0.57, P<0.05). Logistic regression analysis revealed that sCD36, resistin, and total cholesterol (TC) influenced T2DM combined with NAFLD ROC curve analysis revealed that the areas under the curve (AUCs) of sCD36, resistin, and Adropin alone and incombination with T2DM combined with NAFLD were 0.81, 0.74, 0.72, and 0.89, respectively, and the predictive efficacy of the combination of the three in predicting T2DM combined with NAFLD was significantly greater than that of the single indices alone (P<0.05). Conclusion The serum levels of sCD36 and resistin were elevated, and the level of adropin was decreased in patients with T2DMcombined with NAFLD, and the combination of the three indicators was more effective in predicting T2DM combined with NAFLD.
查看全文   查看/发表评论  下载PDF阅读器
关闭

分享按钮