| 屈芸,孙文恺,孟颖,等.基于色氨酸 -芳香烃受体代谢通路探讨溃疡性结肠炎肠屏障修复的研究进展[J].安徽医药,2024,28(7):1291-1295. |
| 基于色氨酸 -芳香烃受体代谢通路探讨溃疡性结肠炎肠屏障修复的研究进展 |
| Research progress on intestinal barrier repair in ulcerative colitis based on the tryptophan-ary1 hydrocarbon receptor metabolic pathway |
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| DOI：10.3969/j.issn.1009-6469.2024.07.005 |
| 中文关键词: 结肠炎，溃疡性 色氨酸 芳香烃受体 肠屏障 功能受损 |
| 英文关键词: Colitis,ulcerative Tryptophan Aryl hydrocarbon receptor Intestinal barrier Functional impairment |
| 基金项目:张家港市社会发展技术创新研究项目( ZKS2124)；张家港市卫生青年科技项目( ZJGQNKJ202108，ZJGQNKJ202235)；苏州市科技发展计划项目( SKYXD2022066) |
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| 中文摘要: |
| 溃疡性结肠炎(UC)是结肠黏膜的一种特发性慢性炎症性疾病，近年来 UC的发病率在各国逐渐增加，其发病与肠屏障功能受损密切相关，色氨酸通过多种代谢途径产生芳香烃受体(AhR)的配体，这些配体可以与 AhR结合并刺激下游靶基因的表达，从而修复肠屏障的功能。调节 Trp-AhR通路可能成为治疗 UC的有效途径。该研究就该通路在修复 UC肠屏障的研究进展作一综述。 |
| 英文摘要: |
| Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of colonic mucosa. In recent years, the incidence rateof UC has gradually increased in various countries, and its incidence is closely related to the impairment of intestinal barrier function.Tryptophan (Trp) produces ligands of ary1 hydrocarbon receptor (AhR) through a variety of metabolic pathways. These ligands can bindwith AhR and stimulate the expression of downstream target genes, thereby repairing the function of the intestinal barrier. Regulatingthe Trp-AhR pathway may become an effective way to treat UC. This study reviews the research progress of this pathway in repairingUC intestinal barrier. |
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