文章摘要
陈露露,苏峰,许金波,等.A型肉毒毒素注射联合悬吊训练治疗痉挛型脑性瘫痪尖足的短期疗效观察[J].安徽医药,2024,28(7):1394-1398.
A型肉毒毒素注射联合悬吊训练治疗痉挛型脑性瘫痪尖足的短期疗效观察
Short-term efficacy of botulinum toxin type A injection combined with suspension training in the treatment of spastic cerebral palsy with pointed feet
  
DOI:10.3969/j.issn.1009-6469.2024.07.027
中文关键词: 脑性瘫痪  尖足  A型肉毒毒素  悬吊训练  临床疗效
英文关键词: Cerebral palsy  Pointed feet  Botulinum toxin type A  Suspension training  Clinical efficacy
基金项目:安徽省儿童医院中青年优秀科技人才项目( 20etyy007)
作者单位E-mail
陈露露 安徽省儿童医院、国家儿童区域医疗中心康复科安徽合肥230051  
苏峰 中国药科大学药学院江苏南京 211198
合肥医工医药股份有限公司安徽合肥 230088 
 
许金波 安徽省儿童医院、国家儿童区域医疗中心康复科安徽合肥230051  
朱清 安徽省儿童医院、国家儿童区域医疗中心康复科安徽合肥230051  
罗媛媛 安徽省儿童医院、国家儿童区域医疗中心康复科安徽合肥230051  
梁栋 安徽省儿童医院、国家儿童区域医疗中心康复科安徽合肥230051  
李红 安徽省儿童医院、国家儿童区域医疗中心康复科安徽合肥230051 2623115155@qq.com 
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中文摘要:
      目的研究 A型肉毒毒素( BTX-A)注射联合悬吊训练治疗痉挛型脑性瘫痪尖足的短期疗效。方法收集 2021年 1— 12月就诊于安徽省儿童医院康复科痉挛型脑性瘫痪尖足病例共 63例,按随机数字表法分成对照组 30例,观察组 33例,对照组给予常规康复治疗联合悬吊训练,观察组在对照组基础上联合 A型肉毒毒素注射,分别在治疗前、治疗 4周后对两组病儿进行改良 Tardieu量表( MTS)评估、改良 Ashworth量表( MAS)评估、粗大运动功能测试量表( GMFM-88)评估。结果治疗 4周后,两组病儿的 MTS得分、 MAS得分、 GMFM-88 D区和 E区得分均较治疗前改善,且观察组 MTS得分[伸膝位 R1(-7.88±1.40)分、 R2(16.36±1.19)分、 R2-R1(24.24±2.56)分;屈膝位 R1(10.18±1.30)分、 R2(22.58±1.62)分、 R2-R1(12.39±0.75)分]、 MAS得分[( 1.82±0.85)分]、 GMFM-88区得分[( 33.42±5.20)分]、 E区得分[( 50.88±5.32)分]的改善程度优于对照组[MTS伸膝位 R1(-10.60±1.13)分、 R2(12.23±1.33)分、 R2-R1(22.83±0.53)分;屈膝位 R1(5.03±0.72)分、 R2(18.40±1.16)分、 R2-R1(13.37±0.85)分; MAS(2.37±1.03)分; GMFM-88D区( 30.40±4.67)分, E区( 43.83±4.33)分,均 P<0.05]。结论 A型肉毒毒素注射联合悬吊训练治疗短期内能提高痉挛型脑性瘫痪尖足的临床疗效。
英文摘要:
      Objective To study the short-term efficacy of botulinum toxin type A (BTX-A) injection combined with suspension training in the treatment of spastic cerebral palsy with pointed feet.Methods A total of 63 cases of spastic cerebral palsy with pointed feetattending the Rehabilitation Department of Anhui Provincial Children's Hospital from January to December 2021 were collected andrandomly assigned into 30 cases in the control group and 33 cases in the observation group. The control group was given conventionalrehabilitation practice combined with suspension training, and the observation group was combined with BTX-A injection on the basisof the control group. The children in both groups were evaluated with the modified Tardieu scale (MTS), modified Ashworth scale(MAS), and Gross Motor Function Test Scale (GMFM-88) before and after 4 weeks of treatment.Results After 4 weeks of treatment, the MTS scores, MAS scores, GMFM-88 Zone D scores and Zone E scores in both groups improved compared with those before treatment. The improvement of MTS score [R1 (-7.88±1.40) points, R2 (16.36±1.19) points, R2-R1 (24.24±2.56) points in extended kneeposition; R1 (10.18±1.30) points, R2 (22.58±1.62) points, R2 - R1 (12.39±0.75) points in flexed knee position], MAS score [(1.82±0.85) points], GMFM-88 zone score [(33.42±5.20) points], and E zone score [(50.88±5.32) points] improved better than those in the control group [MTS score in extended knee position R1 (-10.60±1.13), R2 (12.23±1.33), R2-R1 (22.83±0.53) points; MTS score in flexedknee position R1 (5.03±0.72) points, R2 (18.40±1.16) points, R2-R1 (13.37±0.85) points; MAS score (2.37±1.03) points; GMFM-88 D zone score (30.40±4.67) points, E zone score (43.83±4.33) points, all P<0.05].Conclusion BTX-A injection combined with suspension training treatment can improve the short-term clinical efficacy of spastic cerebral palsy acromegaly with pointed feet.
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