| 赵建,黄新生,贾婷婷,等.当贡 -3胶囊联合盐酸替罗非班注射液治疗气虚血瘀证不稳定型心绞痛的疗效观察[J].安徽医药,2024,28(7):1456-1460. |
| 当贡 -3胶囊联合盐酸替罗非班注射液治疗气虚血瘀证不稳定型心绞痛的疗效观察 |
| Efficacy observation of Danggong-3 capsules combined with tirofiban hydrochloride injection in the treatment of unstable angina pectoris with Qi deficiency and blood stasis syndrome |
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| DOI：10.3969/j.issn.1009-6469.2024.07.040 |
| 中文关键词: 心绞痛，不稳定型 气虚血瘀 当贡 -3胶囊 盐酸替罗非班注射液 疗效 |
| 英文关键词: Angina,unstable Qi deficiency and blood stasis Danggong-3 capsule Tirofiban hydrochloride injection Curative effect |
| 基金项目:内蒙古自治区科技计划项目( JH20180086) |
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| 中文摘要: |
| 目的探究当贡 -3胶囊联合盐酸替罗非班注射液治疗气虚血瘀证不稳定型心绞痛的治疗效果。方法选取内蒙古自治区中医医院 2018年 1月至 2021年 6月医治的不稳定型心绞痛病人 120例，按随机数字表法分为两组各 60例，对照组用盐酸替罗非班注射液治疗，试验组用当贡 -3胶囊联合盐酸替罗非班注射液治疗。对两组病人的治疗效果、心绞痛发作情况、炎症水平、血脂水平、不良心血管事件发生情况进行比较分析。结果试验组整体疗效及治疗总有效率显著高于对照组( P<0.05)。治疗后，两组病人的心绞痛发作次数减少，持续时间缩短，肿瘤坏死因子 α(TNF-α)、 C反应蛋白( CRP)水平下降，白细胞介素 -10(IL-10)水平升高，且试验组心绞痛发作次数、持续时间、 TNF-α、CRP水平［(0.72±0.14)次、(2.47±0.48)min、(17.49±3.48)ng/ L、(2.19±0.42)mg/L］显著低于对照组［(0.91±0.18)次、(3.24±0.64)min、(19.42±3.88)ng/L、(2.71±0.54)mg/L］IL-10水平显著高于对照组( P<0.05)。治疗后，两组病人三酰甘油( TG)、总胆固醇( TC)、低密度脂蛋白( LDL-C)水平下降，高密，度脂蛋白( HDLC)水平升高，试验组 TG、TC、LDL-C水平低于对照组， HDL-C水平高于对照组(P<0.05)。结论当贡 -3胶囊联合盐酸替罗非班注射液治疗气虚血瘀证不稳定性心绞痛有较好疗效，能够提高治疗效果，调节病人炎症水平和血脂水平，从而缓解病人病情。 |
| 英文摘要: |
| Objective To explore the therapeutic effect of Danggong-3 capsules combined with tirofiban hydrochloride injection in the treatment of unstable angina pectoris with Qi deficiency and blood stasis syndrome.Methods A total of 120 patients with unstable angina pectoris treated in Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine from January 2018 to June2021 were assigned into two groups with 60 cases in each group using random number table. The control group was treated with tirofiban hydrochloride injection, while the experiment group was treated with Danggong-3 capsules combined with tirofiban hydrochlorideinjection. The efficacy, the onset of angina pectoris, inflammation, blood lipid and adverse cardiovascular events of patients in the twogroups were compared and analyzed.Results The overall curative effect and total effective rate of treatment in the experiment groupwas significantly higher than those in the control group (P<0.05). After treatment, the number of attacks of angina pectoris was reduced,the duration was shortened, the levels of tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) were decreased, and the level of interleukin-10 (IL-10) was increased in both groups, and the number of angina attacks,duration,the levels of TNF-α and CRP [(0.72±0.14) times, (2.47±0.48) min, (17.49±3.48) ng/L, (2.19±0.42) mg/L] in the experiment group were significantly lower than those in thecontrol group [(0.91±0.18) times, (3.24±0.64) min, (19.42±3.88) ng/L, (2.71±0.54) mg/L], while the level of IL-10 was significantly higher than that in the control group (P<0.05). After treatment, the levels of triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) in the two groups were decreased, while the level of high-density lipoprotein (HDL-C) was increased. The levels of TG, TC, and LDL-C in the experiment group were significantly lower than those in the control group, while the level of HDL-C was significantly higher than that in the control group (P<0.05).Conclusion Danggong-3 capsules combined with tirofiban hydrochloride injection has a good effect in the treatment of unstable angina pectoris with Qi deficiency and blood stasis syndrome, which can improve thetherapeutic effect, adjust the inflammation and blood lipid levels of the patients, thereby alleviating the patients' condition. |
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