| 陈梦双,赵宁军,卓晓英,等.可溶性生长刺激表达基因 2蛋白与急性缺血性脑卒中严重程度及预后的相关性[J].安徽医药,2024,28(8):1558-1562. |
| 可溶性生长刺激表达基因 2蛋白与急性缺血性脑卒中严重程度及预后的相关性 |
| Correlation between soluble growth stimulating gene 2 protein and acute ischemic stroke |
| |
| DOI：10.3969/j.issn.1009-6469.2024.08.015 |
| 中文关键词: 脑梗死 卒中 可溶性生长刺激表达基因 2蛋白 预后 危险因素 |
| 英文关键词: Brain infarction Stroke sST2 Prognosis Risk factor |
| 基金项目:徐州市国家临床重点专科培育项目( 2018ZK004)；徐州市重点研发计划(社会发展)医药卫生面上项目( KC22232；KC22236)；徐州医科大学附属医院优秀中青年人才项目( 2021107408) |
|
| 摘要点击次数: 718 |
| 全文下载次数: 417 |
| 中文摘要: |
| 目的探讨可溶性生长刺激表达基因 2蛋白( sST2)水平与急性缺血性脑卒中( AIS)病人神经功能损伤的严重程度之间的关联，并探究其与 90 d功能预后结局的相关性。方法连续性纳入 2022年 1―6月于徐州医科大学附属医院入院的 AIS病人 181例，入院时采用美国国立卫生研究院卒中量表(NIHSS)评分对病人神经功能缺损的严重程度进行评估，出院后 90 d采用改良 Rankin评分( mRS)评估预后。检测血清中的 sST2水平，分析 sST2与脑卒中严重程度及 90 d功能预后结局中的相关性。结果中-重型卒中组病人 sST2水平高于轻型卒中组病人［ 61.0(40.8，124.2)μg/L比 35.5(26.3，48.1)μg/L］(P<0.01)。调整相关混杂因素后高 sST2水平仍是中 -重型卒中的独立危险因素，调整后的 OR值为 1.04，95%CI:(0.02，1.05)。 Spearman等级相关分析结果表明， sST2水平与 NIHSS评分(r=0.44，P<0.01)及出院后 90 d mRS(r=0.51，P<0.01)呈正相关；单因素及多因素 logistic回归分析显示 sST2水平与出院后 90 d功能预后结局密切相关，是功能预后不良的独立危险因素。 sST2取值为 49.51 μg/L时，预测 90 d功能预后功能不良事件发生的灵敏度 74.2%，特异度 84.9%，曲线下面积( AUC)为 0.85，95%CI:(0.79，0.91)P<0.01。结论 sST2与急性缺血性脑卒中神经功能损伤严重程度呈正相关，是急性缺血性脑卒中 90 d功能预后不良的独立危险，因素；它对中 -重型卒中病人及其 90 d功能不良结局有一定的预测价值。 |
| 英文摘要: |
| Objective To explore the relationship between the level of soluble growth stimulating gene 2 protein (sST2) and the sever-ity of neurological function injury in patients with acute ischemic stroke (AIS), and to explore the correlation between the level of sST2protein and the outcome of 90-day functional prognosis.Methods A total of 181 patients with acute ischemic stroke admitted to theAffiliated Hospital of Xuzhou Medical University from January 2022 to June 2022 were included consecutively. The severity of neuro-logical impairment was evaluated with the Stroke Monitoring Scale of the National Institutes of Health (NIHSS) at admission, and theprognosis was evaluated with the modified Rankin Scale (mRS) 90 days after discharge. The serum levels of sST2 were detected, the re-lationship between sST2, the severity of stroke and the outcome of 90-day functional prognosis was analyzed. Results The level of sST2 in patients with moderate to severe stroke was higher than that in patients with mild stroke [61.0 (40.8, 124.2) μg/L vs. 35.5 (26.3, 48.1) μg/L] (P<0.01). After adjusting for the related confounding factors, the high level of sST2 was still an independent risk factor formoderate to severe stroke, and the adjusted OR value was 1.04, 95% CI: (0.02, 1.05). The results of Spearman grade correlation analy-sis showed that the level of sST2 was positively correlated with NIHSS score (rs=0.44, P<0.01) and mRS 90 days after discharge (rs= 0.51, P<0.01). Univariate and multivariate logistic regression analysis showed that the level of sST2 was closely related to the outcomeof functional prognosis 90 days after discharge, and was an independent risk factor for poor functional prognosis. When the value ofsST2 was 49.51 μg/L, the sensitivity of predicting the occurrence of functional adverse events after 90 days of functional prognosis was74.2%, the specificity was 84.9%, and the area under the curve (AUC) was 0.85, 95%CI: (0.79, 0.91), P<0.01.Conclusions sST2 is positively correlated with the severity of neurological function injury in acute ischemic stroke, and is an independent risk factor for poorfunctional prognosis in 90 days after acute ischemic stroke. It has certain predictive value for patients with moderate to severe strokeand their 90-day adverse functional outcome. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
