| 阳映,魏佳莉.线粒体自噬对肾间质纤维化作用的研究进展[J].安徽医药,2024,28(9):1697-1701. |
| 线粒体自噬对肾间质纤维化作用的研究进展 |
| Research advances in mitophagy in renal interstitial fibrosis |
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| DOI：10.3969/j.issn.1009-6469.2024.09.001 |
| 中文关键词: 线粒体自噬 肾间质纤维化 作用机制 调控通路 |
| 英文关键词: Mitophagy Renal interstitial fibrosis Mechanism of action Regulatory pathway |
| 基金项目:国家自然科学基金项目( 82160135) |
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| 中文摘要: |
| 线粒体自噬是普遍存在于哺乳动物中的一种由多种信号通路参与的复杂的生理过程。当机体受到缺氧、去极化等应激因素胁迫时，可诱发线粒体自噬机制。肾间质纤维化( RIF)是肾脏疾病发展至终末期的必经病理过程，研究发现，线粒体自噬与 RIF病程进展密切相关，且线粒体自噬靶向治疗 RIF已成为防治 RIF研究的前沿方向，因此，有必要进一步阐述线粒体自噬与 RIF的关系。该文就线粒体自噬的调控机制、线粒体自噬对 RIF的作用以及 RIF的线粒体自噬调控通路的研究进行了梳理与总结，以期为线粒体自噬靶向治疗 RIF以及新药物的研发提供参考依据。 |
| 英文摘要: |
| Mitochondrial autophagy (mitophagy) is a complex physiological process ubiquitous in mammals, involving multiple signal-ing pathways. When stressed by stress factors such as hypoxia and depolarization, the mitochondrial autophagy mechanism can be in-duced. Renal interstitial fibrosis (RIF) is a necessary pathological process when renal disease develops to terminal stage. Studies havefound that mitophagy is closely related to the progression of RIF, and mitophagy targeting RIF has become the forefront of the preven-tion and treatment of RIF. Therefore, it is necessary to further elaborate on the relationship between mitophagy and RIF. In this paper,the regulation mechanism of mitophagy, the role of mitophagy in the treatment of RIF and the mitophagy regulation pathway of RIF aresummarized to provide reference for the targeted treatment of RIF and the research and development of new drugs. |
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