| 孙蕾,薄建萍.慢性阻塞性肺疾病的免疫机制及颗粒酶的潜在作用[J].安徽医药,2024,28(9):1711-1714. |
| 慢性阻塞性肺疾病的免疫机制及颗粒酶的潜在作用 |
| Immune mechanism of chronic obstructive pulmonary disease and the potential role of granzyme |
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| DOI：10.3969/j.issn.1009-6469.2024.09.004 |
| 中文关键词: 肺疾病，慢性阻塞性 发病机制 炎症趋化因子类 免疫 颗粒酶 炎症 |
| 英文关键词: Pulmonary disease, chronic obstructive Pathogenesis Chemokines Immunization Granzyme Inflammation |
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| 中文摘要: |
| 慢性阻塞性肺疾病( COPD)是以持续存在的气流受限和呼吸系统症状为特征的一种疾病，肺功能检查是评估气流受限的主要手段。随着研究的进展， COPD的免疫机制被进一步阐明。当气道黏膜接触到相应刺激后，肺组织局部固有免疫被激活，释放促炎因子和趋化因子触发炎症反应，在小气道和肺实质中 T淋巴细胞、 B淋巴细胞的数量明显增加，由其介导的适应性免疫失调是 COPD病程进展的重要原因之一，同时，新的重要分子如颗粒酶逐渐成为研究热点。 |
| 英文摘要: |
| Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airflow restriction and respiratorysymptoms. Pulmonary function examination is the main means to evaluate airflow restriction. With the progress of researches, the im-mune mechanism of COPD has been further clarified. When airway mucosa is exposed to corresponding stimuli, local innate immunityof lung tissue is activated, and proinflammatory factors and chemokines are released to trigger inflammatory response. The number of Tlymphocytes and B lymphocytes in small airways and lung parenchyma increases significantly. The adaptive immune disorder mediatedby T lymphocytes and B lymphocytes is one of the important reasons for the progression of COPD. Meanwhile, new important moleculessuch as granzyme have gradually become a research hotspot. |
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