| 曹峥,申慧琴.新抗原在结直肠癌中的研究进展[J].安徽医药,2024,28(9):1715-1718. |
| 新抗原在结直肠癌中的研究进展 |
| Advances in neoantigen research in colorectal cancer |
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| DOI：10.3969/j.issn.1009-6469.2024.09.005 |
| 中文关键词: 结直肠肿瘤 肽类 新抗原 新抗原疫苗 过继细胞疗法 临床试验 |
| 英文关键词: Colorectal neoplasms Peptides Neoantigens Neoantigen vaccine Adoptive cell therapy Clinical trials |
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| 中文摘要: |
| 目前，结直肠癌有多种治疗策略，包括手术、化疗、放疗和靶向治疗。最新的研究发现，新抗原是一类肿瘤特异性抗原，被视为许多癌症免疫治疗的新靶点。基于新抗原的免疫治疗策略包括肿瘤疫苗和过继细胞疗法，其目的是通过增强宿主 T细胞对新抗原的免疫反应来消除肿瘤细胞。该文总结了目前发现的结直肠癌新抗原及其免疫原性，并列举了基于新抗原治疗结直肠癌的临床试验，最后对当前研究面临的问题与挑战提出思考。 |
| 英文摘要: |
| At present, there are a variety of treatment strategies for colorectal cancer, including surgery, chemotherapy, radiotherapyand targeted therapy. Recent studies have shown that neoantigens, a class of tumor-specific antigens, are considered new targets for im- munotherapy in many cancers. Neoantigen-based immunotherapeutic strategies include tumor vaccines and adoptive cell therapies,which aim to eliminate tumor cells by enhancing the immune response of host T cells to neoantigens. This paper summarizes the cur-rently identified colorectal cancer neoantigens and their immunogenicity, lists clinical trials of neoantigen-based therapy for colorectal cancer, and concludes with reflections on the issues and challenges facing current research. |
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