| 倪银芳,吴兴花.孕妇血清成纤维细胞生长因子 4和成纤维细胞生长因子受体 4水平与妊娠期糖尿病发生风险的相关性研究[J].安徽医药,2024,28(9):1783-1786. |
| 孕妇血清成纤维细胞生长因子 4和成纤维细胞生长因子受体 4水平与妊娠期糖尿病发生风险的相关性研究 |
| Study on the correlation between serum FGF4 and FGFR4 levels in pregnant women and the risk of diabetes during pregnancy |
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| DOI：10.3969/j.issn.1009-6469.2024.09.019 |
| 中文关键词: 糖尿病，妊娠 成纤维细胞生长因子 4 成纤维细胞生长因子受体 4 相关性分析 预测效能 |
| 英文关键词: Diabetes, gestational Fibroblast growth factor 4 Fibroblast growth factor receptor 4 Correlation analysis Predic- tive efficacy |
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| 中文摘要: |
| 目的探讨血清成纤维细胞生长因子 4(FGF4)、成纤维细胞生长因子受体 4(FGFR4)水平与妊娠期糖尿病发生风险的相关性。方法选取 2019年 1月至 2021年 1月宁德师范学院附属宁德市医院收治的妊娠期糖尿病病人 94例为研究组，另外选取同期在该院定期进行产检的健康孕妇 94例为对照组。收集病人的一般临床资料，酶联免疫吸附测定检测血清 FGF4和 FGFR4水平，血糖分析仪检测糖代谢指标水平。采用 Pearson法分析血清 FGF4与 FGFR4的相关性及二者与糖代谢指标的相关性，多因素 logistic回归分析妊娠期糖尿病发生的影响因素；受试者操作特征曲线( ROC曲线)分析血清 FGF4和 FGFR4对妊娠期糖尿病发生的预测价值。结果研究组血清 FGF4(186.45±34.87)ng/L高于对照组( 149.83±29.90)ng/L(P<0.05)；研究组血清 FGFR4(194.28±41.59)ng/L高于对照组( 168.92±37.55)ng/L(P<0.05)。研究组病人空腹血糖、餐后 2h血糖( 2 hPG)、糖化血红蛋白( HbA1c)、空腹胰岛素( FINS)与胰岛素抵抗指数( HOMA-IR)均显著高于对照组，差异有统计学意义( P<0.05)。经 Pearson相关性分析发现，妊娠期糖尿病病人血清 FGF4与 FGFR4水平呈正相关( P<0.05)，血清 FGF4、FGFR4与空腹血糖、 2 hPG、HbA1c、FINS及 HOMA-IR均呈正相关( P<0.05)。 logistic回归分析结果显示， FGF4、FGFR4、空腹血糖和 HOMA-IR是妊娠期糖尿病发生的独立危险因素( P<0.05)。血清 FGF4、FGFR4单独及联合预测妊娠期糖尿病发生的 AUC分别为 0.80、0.75和0.88，灵敏度分别为 85.11%、61.70%和 82.98%，特异度分别为 60.64%、77.66%和 80.85%；二者联合的预测效能显著优于 FGF4、 FGFR4各自单独预测( ZFGF4-联合 =3.33、ZFGFR4-联合 =4.37，P<0.05)。结论妊娠期糖尿病病人血清 FGF4和 FGFR4水平高表达，与糖代谢指标均呈正相关，对妊娠期糖尿病病人具有一定的预测价值，临床应用价值较大。 |
| 英文摘要: |
| Objective To investigate the correlation between the serum levels of fibroblast growth factor 4 (FGF4) and fibroblastgrowth factor receptor 4 (FGFR4) and the risk of developing gestational diabetes mellitus.Methods A total of 94 patients with gesta-tional diabetes mellitus admitted to Ningde City Hospital affiliated to Ningde Normal College from January 2019 to January 2021 wereselected as the study group, and another 94 healthy pregnant women who underwent regular antenatal examinations at the hospital dur-ing the same period were selected as the control group. The general clinical data of the patients were collected, the serum levels ofFGF4 and FGFR4 were detected by enzyme-linked immunosorbent assay (ELISA), and the levels of glucose metabolism indices weredetected by a glucose analyzer. Pearson's method was used to analyze the correlation between the serum FGF4 and FGFR4 levels andbetween the serum FGF4 and FGFR4 levels and glucose metabolism indices, and multivariate logistic regression was used to analyzethe factors influencing the occurrence of gestational diabetes. The predictive value of the serum FGF4 and FGFR4 levels for the occur-rence of gestational diabetes was analyzed by receiver operating characteristic (ROC) curve analysis.Results Serum FGF4 (186.45± 34.87) ng/L in the study group was greater than that in the control group (149.83±29.90) ng/L (P<0.05); serum FGFR4 (194.28±41.59) ng/L in the study group was greater than that in the control group (168.92±37.55) ng/L (P<0.05). The fasting blood glucose, postprandi-al blood glucose 2 (2 hPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and insulin resistance index (HOMA-IR) of the pa- tients in the study group were significantly greater than those in the control group (P<0.05). Pearson correlation analysis revealed thatthe serum FGF4 and FGFR4 levels in patients with gestational diabetes were positively correlated (P<0.05), and the serum FGF4 andFGFR4 levels were positively correlated with fasting blood glucose, 2 hPG, HbA1c, FINS and HOMA-IR (P<0.05). Logistic regression analysis revealed that FGF4, FGFR4, fasting blood glucose and HOMA-IR were independent risk factors for the development of gesta- tional diabetes (P<0.05). The AUCs of serum FGF4 and FGFR4 alone and in combination for predicting the occurrence of gestational diabetes were 0.80, 0.75 and 0.88, respectively, with sensitivities of 85.11%, 61.70% and 82.98%, respectively, and specificities of60.64%, 77.66% and 80.85%, respectively. The predictive efficiency of the combination of the two agents was significantly better thanthat of either FGF4 or FGFR4 alone (ZFGF4-combination=3.33, ZFGFR4-combination=4.37, P < 0.05).Conclusion The serum levels of FGF4 and FG- FR4 in patients with gestational diabetes were strongly correlated and positively correlated with the indicators of glucose metabolism,which has a certain predictive value for patients with gestational diabetes mellitus with greater clinical value. |
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