| 焦丽华,王晓青,刘寅.血清氨基末端脑肽钠前体、心肌肌钙蛋白 I联合检测对川崎病合并冠状动脉损害的早期诊断价值[J].安徽医药,2024,28(9):1814-1818. |
| 血清氨基末端脑肽钠前体、心肌肌钙蛋白 I联合检测对川崎病合并冠状动脉损害的早期诊断价值 |
| Early diagnostic value of combined serum NT-proBNP and CTnI detection in Kawasaki disease complicated with coronary artery lesions |
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| DOI：10.3969/j.issn.1009-6469.2024.09.026 |
| 中文关键词: 黏膜皮肤淋巴结综合征 冠状动脉损害 氨基末端脑肽钠前体 心肌肌钙蛋白 I 诊断价值 |
| 英文关键词: Mucocutaneous lymph node syndrome Coronary artery lesion N terminal pro B type natriuretic peptide Cardiac tro- ponin I Diagnostic value |
| 基金项目:2022年度河北省医学科学研究课题计划项目( 20221771) |
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| 中文摘要: |
| 目的探讨血清氨基末端脑肽钠前体( NT-proBNP)心肌肌钙蛋白(I CTnI)联合检测对川崎病合并冠状动脉损害( CAL)的早期诊断价值。方法选择 2019年 9月至 2022年 5月唐山、市妇幼保健院收治的 182例急性期川崎病病儿(川崎病组)和 182例健康儿童(对照组)为研究对象，川崎病病儿根据入院时心脏超声检查结果分为 CAL组( n=38)和无 CAL(N-CAL)组(n=144)。比较各组血清 NT-proBNP、CTnI水平；多因素 logistic回归分析川崎病合并 CAL的影响因素；血清 NT-proBNP、CTnI对川崎病合并 CAL的诊断效能采用受试者操作特征曲线( ROC曲线)。结果川崎病组血清 NT-proBNP(204.96±41.37)ng/L、CTnI(5.78± |
| 英文摘要: |
| Objective To investigate the early diagnostic value of combined serum N terminal pro B type natriuretic peptide (NTproBNP) and cardiac troponin I (CTnI) for Kawasaki disease complicated with coronary artery lesions (CALs).Methods A total of 182 infants with acute-phase Kawasaki disease (Kawasaki disease group) and 182 healthy infants (control group) admitted to Tangshan Ma-ternal and Child Health Hospital between September 2019 and May 2022 were selected as the study subjects, and the Kawasaki dis-ease infants were divided into a CAL group (n=38) and a non-CAL (N-CAL) group (n=144) according to the results of the cardiac ultra- sound examination at the time of hospital admission. The levels of serum NT-proBNP and CTnI in each group were compared; multivari-ate logistic regression was performed to analyze the factors influencing Kawasaki disease combined with CAL; and the diagnostic effica-cy of serum NT-proBNP and CTnI for Kawasaki disease complicated with CAL was determined by using receiver operating characteris-tic (ROC) curve.Results The serum levels of NT-proBNP (204.96±41.37) ng/L and CTnI (5.78±0.82) μg/L in the Kawasaki diseasegroup were greater than those in the control group [(48.52±7.18) ng/L, (1.94±0.16) μg/L] (P<0.05). The serum levels of NT-proBNP (263.91±52.68) ng/L and CTnI (6.63±0.97) μg/L in the CAL group were greater than those in the N-CAL group [(189.40±38.39) ng/L, (5.56±0.78) μg/L] (P < 0.05). Logistic regression analysis revealed that fever duration, C-reactive protein, NT-proBNP, and CTnI were risk factors for the development of CALs in infants with Kawasaki disease (P<0.05). The ROC curve showed that the AUC and 95% CI for the serum NT-proBNP concentration, CTnI concentration, and combined diagnosis of combined CALs in infants with Kawasaki dis-ease were 0.84 (0.77, 0.91), 0.81 (0.74, 0.89), and 0.92 (0.87, 0.96), respectively.Conclusion The elevated serum levels of NT-proB-NP and CTnI in the infants with Kawasaki disease complicated with CALs are closely related to CALs, and the combination of the twocan be used for the early diagnosis of CALs. |
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