| 卫仙洪,何霞,李玲,等.子痫前期血清中血管生成抑制蛋白 1水平与胎儿生长受限的相关性分析[J].安徽医药,2024,28(9):1862-1865. |
| 子痫前期血清中血管生成抑制蛋白 1水平与胎儿生长受限的相关性分析 |
| Correlation analysis between serum levels of angiogenic inhibitory protein-1 and fetal growth restriction in preeclampsia |
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| DOI：10.3969/j.issn.1009-6469.2024.09.036 |
| 中文关键词: 先兆子痫 胎儿生长迟缓 血管生成抑制蛋白 相关性 预测 |
| 英文关键词: Preeclampsia Fetal growth retardation Angiogenesis inhibitory protein Correlation Predictive |
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| 中文摘要: |
| 目的检测子痫前期( PE)病人血清中血管生成抑制蛋白 1(VASH1)的水平，分析其与胎儿生长受限( FGR)的相关性。方法选取 2020年 3月至 2022年 3月雅安市人民医院收治的 152例 PE病人作为研究对象，其中发生 FGR的有 80例( FGR组)，未发生 FGR的有 72例(非 FGR组)。采用酶联免疫吸附法测定血清 VASH1水平；受试者操作特征曲线(ROC曲线)分析血清 VASH1水平对 PE病人发生 FGR的预测价值； logistic回归分析 PE病人发生 FGR的影响因素。结果 FGR组 PE病人尿蛋白(186.71±11.15)mg/24 h、收缩压( 166.66±10.11)mmHg、舒张压( 95.52±7.17)mmHg水平均显著高于非 FGR组［( 167.62±10.51) mg/24 h、(153.62±9.19)mmHg、(89.80±6.11)mmHg］(均 P<0.05)。 FGR组 PE病人血清 VASH1水平( 467.89±111.24)ng/L显著高于非 FGR组( 328.33±69.54)ng/L(P<0.05)。 FGR组 PE病人胎儿胫骨长度( 5.93±0.20)cm、双顶径( 7.87±0.21)cm、头围( 28.15±1.27)cm显著低于非 FGR组［(6.59±0.38)cm、(8.64±0.47)cm、(31.43±1.36)cm］(均 P<0.05)。 FGR病人血清中 VASH1的水平与尿蛋白、收缩压、舒张压水平呈正相关，与胎儿胫骨长度、双顶径、头围水平呈负相关(均 P<0.05)。单因素回归分析表明，高水平 VASH1、高水平尿蛋白、高水平舒张压是影响 FGR发生的危险因素( P<0.05)；多因素分析得知，高水平 VASH1、高水平尿蛋白、高水平舒张压是影响 FGR发生的独立危险因素( P<0.05)。结论 FGR组 PE病人血清 VASH1水平显著高于非 FGR组，是影响 PE病人发生 FGR的独立危险因素，检测血清 VASH1水平有利于筛查出 PE病人中 FGR发生风险较高的病人。 |
| 英文摘要: |
| Objective To measure the level of serum angiogenic inhibitory protein 1 (VASH1) in patients with preeclampsia (PE) andanalyze its correlation with fetal growth restriction (FGR).Methods A total of 152 PE patients admitted to Ya'an People's Hospitalfrom March 2020 to March 2022 were included in the study; 80 of these patients developed FGR (FGR group), and 72 did not developFGR (non-FGR group). The serum VASH1 concentration was measured by enzyme-linked immunosorbent assay (ELISA); the predictivevalue of the serum VASH1 concentration for the occurrence of FGR in PE patients was analyzed by receiver operating characteristic(ROC) curve analysis; and the factors influencing the occurrence of FGR in PE patients were analyzed by logistic regression.Results Urinary protein (186.71±11.15) mg/24 h, systolic blood pressure (166.66±10.11) mmHg, and diastolic blood pressure (95.52±7.17)mmHg were significantly greater in PE patients in the FGR group than in those in the non-FGR group [(167.62±10.51) mg/24 h, (153.62±9.19) mmHg, and (89.80±6.11) mmHg, respectively] (P<0.05). The serum VASH1 level of PE patients in the FGR group(467.89±111.24) ng/L was significantly greater than that in the non-FGR group (328.33±69.54) ng/L (P<0.05). In the PE patients in theFGR group, fetal tibia length (5.93±0.20) cm, biparietal diameter (7.87±0.21) cm, and head circumference (28.15±1.27) cm were signif-icantly lower than those in the non-FGR group [(6.59±0.38) cm, (8.64±0.47) cm, and (31.43±1.36) cm, respectively] (P<0.05). The se-rum VASH1 level in FGR patients was positively correlated with urine protein, systolic blood pressure and diastolic blood pressure andnegatively correlated with fetal tibia length, biparietal diameter and head circumference (P<0.05). Univariate regression analysis re-vealed that high VASH1 levels, high urine protein levels, and high diastolic blood pressure were risk factors for affecting the occur-rence of FGR (P<0.05). Multivariate analysis revealed that a high level of VASH1, a high level of urine protein, and a high diastolicblood pressure were independent risk factors for the occurrence of FGR (P<0.05).Conclusion The serum VASH1 level of PE patients in FGR group was obviously greater than that in the non-FGR group, which was an independent risk factor affecting the occurrence ofFGR in PE patients and the detection of the serum VASH1 level was conducive to identifying PE patients with a greater risk of FGR. |
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