| 谢瑜欢,苏芮,刘潞,等.CD4+T细胞亚群在皮肌炎发病机制中的研究进展[J].安徽医药,2024,28(10):1926-1930. |
| CD4+T细胞亚群在皮肌炎发病机制中的研究进展 |
| Research progress on CD4+ T cell subsets in the pathogenesis of dermatomyositis |
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| DOI：10.3969/j.issn.1009-6469.2024.10.005 |
| 中文关键词: 皮肌炎 CD4+T细胞亚群 免疫平衡 辅助性 T细胞 1型/辅助性 T细胞 2型 辅助性 T细胞 17型/调节性 T细胞 综述 |
| 英文关键词: Dermatomyositis CD4+ T cell subsets Immune balance Th1/Th2 Th17/Treg Review |
| 基金项目:国家自然科学基金项目( 81971543) |
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| 中文摘要: |
| 目的探讨皮肌炎(DM)的免疫学发病机制，特别关注 CD4+T细胞亚群在其发病过程中的作用。方法从免疫失衡的角度，通过分析近 10年来的文献，深入探讨了 DM与 CD4+T细胞亚群的关联，全面梳理了细胞因子及相关信号分子等方面的信息。结果主导免疫反应的 CD4+T细胞亚群，在 DM的发病过程中有显著影响。其中，辅助性 T细胞 1型(Th1)与 Th2和 Th17与调节性 T细胞(Tregs)比值的不平衡在 DM的病理过程中起着核心作用。新发现的 CD4+T细胞亚群， Tph细胞(PD-1hiCXCR5?CD4+)可能也参与 DM的发病过程。结论 CD4+T细胞因子的异常表达及其网络失衡参与了 DM的免疫学发病机制，为治疗 DM提供了新的视角。 |
| 英文摘要: |
| Objective To investigate the immunological pathogenesis of dermatomyositis (DM), with a particular focus on the role of CD4+ T cell subsets in its development.Methods From the perspective of immune imbalance, we deeply explored the association between DM and CD4+ T cell subsets by analyzing literature from the past decade. We comprehensively reviewed information regardingcytokines and related signaling molecules.Results CD4+ T cell subsets that dominated the immune response had a significant impacton the pathogenesis of DM. Among them, the imbalance in the ratio of Th1 to Th2 and Th17 to regulatory T cells (Tregs) played a central role in the pathology of DM. Additionally, newly identified CD4+ T cell subsets, specifically Tph cells (PD-1hi CXCR5? CD4+), might also be involved in the pathogenesis of DM.Conclusion The abnormal expression of CD4+ T cell cytokines and the imbalance of theirnetwork are involved in the immunological pathogenesis of DM, providing new perspectives for the treatment of DM. |
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