| Objective To investigate the association between metabolic syndrome and lower urinary tract symptoms in middle-aged and older men.Methods A total of 432 middle-aged and elderly male patients who were admitted to the First Affiliated Hospital ofXinxiang Medical University due to lower urinary tract symptoms from December 2021 to March 2023 were selected as the researchsubjects. The 432 patients were assigned into the following five groups: the metabolic syndrome group (with all three diagnoses of hypertension, diabetes and obesity, 39 cases), the non-triple-negative group (without any of the diagnoses of hypertension, diabetes and obesity, 55 cases), the hypertension group (with only the diagnosis of hypertension, 105 cases), the diabetes group (with only the diagnosis ofdiabetes, 83 cases), and the obesity group (with only the diagnosis of obesity, 150 cases). The basic information of all patients, includingage, body mass, height, creatinine value, history of diagnosis and treatment of hypertension and diabetes and other clinical data werecollected. The International Prostate Symptom Score (IPSS) and Health-related Quality of Life (HRQOL) questionnaires were conducted. Finally, free uroflowmetry and bladder residual urine volume (residual urine volume, RUV) measurement were performed on the patients.Results The total IPSS score, HRQOL score, and RUV of the metabolic syndrome group were significantly higher than those of the non-triple-negative group (P < 0.05), and the maximum urine flow rate [13.6 (9.6, 17.6) mL/s vs. 17.6 (13.6, 22.2) mL/s] and average urine flow rate [6.8 (4.9, 8.7) mL/s vs. 8.6 (6.7, 11.3) mL/s] were significantly lower than those of the non-triple-negative group (P < 0.05). There was no statistically significant difference in age and creatinine value between the two groups. The total IPSS score,HRQOL score, and RUV value of the hypertension group were significantly higher than those of the non-triple-negative group (P < 0.05), and the maximum urine flow rate and average urine flow rate were significantly lower than those of the non-triple-negative group (P < 0.05). There was no statistically significant difference in age and creatinine value between the two groups. The total IPSS score,HRQOL score, and creatinine value of the diabetes group were significantly higher than those of the non-triple-negative group (P < 0.05), and the maximum urine flow rate and average urine flow rate were significantly lower than those of the non-triple-negative group (P < 0.05). There was no statistically significant difference in age and RUV between the two groups. The total IPSS score, HRQOLscore, and creatinine value of the obesity group were significantly higher than those of the non-triple-negative group (P < 0.05). Therewas no statistically significant difference in age, maximum urine flow rate, average urine flow rate and RUV between the two groups.Conclusion Metabolic syndrome significantly aggravates lower urinary tract symptoms in middle-aged and older men and affects theirquality of life. Hypertension, diabetes and obesity in metabolic abnormalities may be risk factors for lower urinary tract symptoms. |
