| 管鑫蕊,李连家,王道方.白细胞介素 -34、脂肪细胞型脂肪酸结合蛋白 4与小儿支气管哮喘的关系[J].安徽医药,2024,28(10):2039-2043. |
| 白细胞介素 -34、脂肪细胞型脂肪酸结合蛋白 4与小儿支气管哮喘的关系 |
| The relationship between interleukin-34, adipocyte fatty acid binding protein 4, and pediatric bronchial asthma |
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| DOI：10.3969/j.issn.1009-6469.2024.10.027 |
| 中文关键词: 支气管哮喘 白细胞介素 -34 脂肪细胞型脂肪酸结合蛋白 4 控制水平 儿童 |
| 英文关键词: Bronchial asthma Interleukin-34 Adipocyte fatty acid binding protein 4 Control level Children |
| 基金项目:山东省中医药科技项目( M-2022126) |
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| 中文摘要: |
| 目的探讨血清白细胞介素 -34(IL-34)、脂肪细胞型脂肪酸结合蛋白 4(FABP4)对支气管哮喘病儿病情及控制水平的评估价值。方法收集聊城市第二人民医院 2020年 6月至 2023年 1月治疗的 97例支气管哮喘病儿为病例组，依据病儿病情程度分为轻度哮喘组 32例、中度哮喘组 41例、重度哮喘组 24例，依据病儿病情控制水平分为控制组 56例和未控制组 41例；另选取 95例体检健康儿童作为对照组，比较各组血清 IL-34、FABP4水平；采用 logistic回归分析支气管哮喘病儿病情控制水平的影响因素；采用受试者操作特征曲线(ROC曲线)分析血清 IL-34、FABP4水平对支气管哮喘病儿病情未控制的评估价值。结果病例组血清 IL-34［(25.74±7.31)ng/L比( 2.46±0.73)ng/L］、 FABP4［(27.82±4.10)μg/L比(11.69±3.07)ng/L］水平高于对照组( P<0.05)。重度哮喘组血清 IL-34［( 34.78±9.31)ng/L比( 25.82±7.26)ng/L比( 18.79±6.64)ng/L］、 FABP4［( 37.14±7.40)μg/L比( 28.04±4.75)μg/L比(20.55±5.15)μg/L］水平高于中度哮喘组和轻度哮喘组，中度哮喘组血清 IL-34、FABP4水平高于轻度哮喘组(P<0.05)。未控制组血清 IL-34、FABP4水平及治疗依从性差、有呼吸道感染的病儿比例高于控制组(P<0.05)。IL-34、FABP4是支气管哮喘病儿病情未控制的独立危险因素(P<0.05)。血清 IL-34、FABP4水平单独及联合评估支气管哮喘病儿病情未控制的 AUC分别为 0.78、0.85、0.93。结论血清 IL-34、FABP4水平与支气管哮喘病儿病情程度密切相关，可较好地评估病情控制水平。 |
| 英文摘要: |
| Objective To explore the evaluation value of serum interleukin-34 (IL-34) and adipocyte fatty acid binding protein 4 (FABP4) for the condition and control level of bronchial asthma in children.Methods A total of 97 children with bronchial asthma treated in Liaocheng Second People's Hospital from June 2020 to January 2023 were collected as a case group, according to the severity of the patient's condition, they were grouped into a mild asthma group of 32 cases, a moderate asthma group of 41 cases, and a severeasthma group of 24 cases, according to the level of disease control, the children were grouped into a control group of 56 cases and an uncontrolled group of 41 cases; another 95 healthy children undergoing physical examination were collected as the control group, the levels of IL-34 and FABP4 in serum of each group were compared; Logistic regression analysis was applied to analyze influence factors onthe level of disease control in children with bronchial asthma; receiver operating characteristic (ROC) curve was applied to analyze theevaluation value of serum IL-34 and FABP4 levels for uncontrolled condition in children with bronchial asthma.Results The serum levels of IL-34 [(25.74±7.31) ng/L vs.(2.46±0.73) ng/L] and FABP4 [(27.82±4.10)μg/L vs. (11.69±3.07) ng/L] in the case group were higher than those in the control group (P<0.05). The serum levels of IL-34 [(34.78±9.31) ng/L vs. (25.82±7.26) ng/L vs. (18.79±6.64) ng/ L] and FABP4 [(37.14±7.40) μg/L vs. (28.04±4.75) μg/L vs. (20.55±5.15) μg/L] in the severe asthma group were higher than those inthe moderate and mild asthma groups, while the serum levels of IL-34 and FABP4 in the moderate asthma group were higher than those in the mild asthma group (P<0.05). The levels of IL-34 and FABP4 in the serum, and the proportions of children with poor treatmentcompliance and respiratory infections in the uncontrolled group were higher than those in the control group (P<0.05). IL-34 and FABP4 were independent risk factors for uncontrolled condition in children with bronchial asthma (P<0.05). The AUC of uncontrolled condition in children with bronchial asthma evaluated by serum IL-34 and FABP4 levels alone and in combination was 0.78, 0.85, and 0.93, respectively.Conclusion The levels of serum IL-34 and FABP4 are closely related to the severity of bronchial asthma in children, andcan effectively evaluate the level of disease control. |
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