| 单楚笑,孙宜田,朱孟静,等.中性粒细胞计数、单核细胞计数、中性粒细胞与单核细胞比值与间质性肺疾病急性加重短期转归的相关性分析[J].安徽医药,2024,28(10):2043-2049. |
| 中性粒细胞计数、单核细胞计数、中性粒细胞与单核细胞比值与间质性肺疾病急性加重短期转归的相关性分析 |
| Correlation analysis of neutrophil count, monocyte count and NMR with short-term outcome of acute exacerbation of interstitial lung disease |
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| DOI：10.3969/j.issn.1009-6469.2024.10.028 |
| 中文关键词: 肺疾病，间质性 医院死亡率 中性粒细胞 单核细胞 预后 |
| 英文关键词: Lung diseases,interstitial Hospital mortality Neutrophil Monocyte Prognosis |
| 基金项目:江苏省“六大人才高峰”高层次人才项目( WSN-081) |
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| 中文摘要: |
| 目的探讨中性粒细胞( NEU)计数、单核细胞( MON)计数及中性粒细胞与单核细胞比值( NMR)在间质性肺疾病急性加重( AE-ILD)短期转归方面的诊断价值。方法回顾性分析 2020年1月至 2022年1月在徐州医科大学附属医院住院的间质性肺疾病( ILD)病人 137例的临床资料，并进行电话随访，选取健康体检者 100例作为健康对照组，检测比较急性加重( AE)组 50例和稳定期组 87例的基本资料和血清 NEU、MON及 NMR水平变化，评估其在 AE-ILD 28 d内死亡风险评估中的临床价值。结果 ILD病人血清 NEU、MON水平显著高于健康对照组， AE组病人的 NEU［6.68(4.74，9.25)×109/L］和 NMR［14.37(9.71，32.14)］水平明显高于稳定期组［4.10(3.24，5.82)×109/L、9.92(7.45，12.26)］(P<0.05)。在 AE死亡病人组中，血清 NEU、 NMR水平显著升高， MON水平显著下降。当 NEU>6.86×109/L，预测 AE-ILD病人 28 d内死亡风险的灵敏度为 73.7%，特异度为77.4%，曲线下面积( AUC)为 0.73；MON<0.32×109/L，灵敏度为 84.2%，特异度为 93.5%，AUC为 0.89；NMR>16.54，灵敏度为95.8%，特异度为 87.1%，AUC是 0.98。NMR对 AE-ILD病人的 28 d内死亡风险预测价值明显高于 NEU与 MON，以上均差异有统计学意义( P<0.05)。结论当 ILD病人发生 AE时，病人的 NEU和 NMR水平升高； NEU、NMR升高和 MON降低可以作为预测 AE-ILD病人 28 d内死亡风险的血清学标志物，且 NMR对早期预后的预测能力更高。 |
| 英文摘要: |
| Objective To investigate the diagnostic value of neutrophil count(NEU), monocyte count (MON) and neutrophil-to-monocyte ratio (NMR) with the early prognosis of acute exacerbation of interstitial lung disease (AE-ILD).Methods Patients with clinicallyconfirmed interstitial lung disease (ILD) admitted to the Affiliated Hospital of Xuzhou Medical University between January 2020 and January 2022 were analyzed by a retrospective exploratory approach,and telephone follow-up was conducted. Select 100 healthy examineesas the healthy control group. Compare the basic data and serum NEU, MON, and NMR levels of 50 cases in the acute exacerbation (AE)group and 87 cases in the stable phase group, and evaluate their clinical value in assessing the risk of death within 28 days of AE-ILD.Re? sults Serum NEU and MON levels were significantly higher in patients with ILD than those in healthy controls, and NEU and NMR levels were significantly higher in patients in the AE group [6.68(4.74,9.25)×109/L, 14.37(9.71,32.14)]than those in the stable group[4.10 (3.24,5.82)×109/L, 9.92(7.45,12.26)](P<0.05).In the group of patients who died, serum NEU and NMR levels were significantly higherand MON levels were significantly lower. When NEU>6.86×109/L, the sensitivity of predicting the risk of death within 28 days in AE-ILD patients is 73.7%, the specificity was 77.4% and the area under the curve (AUC) was 0.726; MON<0.32×109/L, the sensitivity was 84.2%,the specificity was 93.5% and the AUC was 0.89; NMR>16.54. The sensitivity was 95.8%, specificity was 87.1% and AUC was 0.98.Thepredictive value of NMR for the risk of death within 28 days of AE-ILD is significantly higher than that of NEU and MON. The differences in the above indicators were statistically significant (P<0.05).Conclusion NEU and NMR levels increased in ILD patients with AE. Increased NEU, NMR and decreased MON can be used as serological markers to predict the risk of death within 28 days in AE-ILD patients, and NMR has a higher predictive power for early prognosis. |
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