| 占寿丰,张津铭,于牧鑫,等.中性粒细胞及中性粒细胞胞外诱捕网促进非酒精性脂肪性肝炎疾病进展的作用[J].安徽医药,2024,28(11):2121-2126. |
| 中性粒细胞及中性粒细胞胞外诱捕网促进非酒精性脂肪性肝炎疾病进展的作用 |
| Role of neutrophils and neutrophil extracellular traps in promoting the progression of nonalcoholic steatohepatitis disease |
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| DOI：10.3969/j.issn.1009-6469.2024.11.001 |
| 中文关键词: 非酒精性脂肪性肝病 中性粒细胞 中性粒细胞胞外诱捕网 |
| 英文关键词: Non-alcoholic fatty liver disease Neutrophil Neutrophil extracellular traps |
| 基金项目:国家自然科学基金( 82100612)；浙江省医药卫生科技计划项目( 2021KY1111)；浙江省自然科学基金( LQ22H030007)；嘉兴市科技计划项目( 2022AY30031) |
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| 中文摘要: |
| 非酒精性脂肪性肝炎( NASH)存在肝细胞损伤、肝脏慢性炎症及不同程度纤维化，并且 NASH促凝活性增强和血栓形成风险增加。 NASH的重要特征是肝脏中性粒细胞浸润，中性粒细胞在促进 NASH炎症及纤维化进展发挥重要作用。中性粒细胞被过度激活时形成的中性粒细胞胞外诱捕网( NETs)可促进肝脏细胞损伤，加重 NASH肝脏炎症及纤维化，并且促进 NASH向肝细胞癌的发展并促进癌症的侵袭和转移。同时 NETs与血栓形成高度相关，炎症与凝血关系密切， NETs促进 NASH炎症进展的能力也可能与血栓形成有关。 |
| 英文摘要: |
| Nonalcoholic steatohepatitis (NASH) is associated with hepatocyte injury, chronic inflammation of the liver, and varying degrees of fibrosis, with enhanced coagulant activity and increased risk of thrombosis. The infiltration of neutrophils in the liver is an important feature of NASH, and they play a crucial role in promoting inflammation and fibrosis progression. Excessive activation of neutrophils leads to the formation of neutrophil extracellular traps (NETs), which can exacerbate liver injury, aggravate inflammation and fibrosis in NASH, facilitate the development of hepatocellular carcinoma, and promote cancer invasion and metastasis. Meanwhile, NETswere highly correlated with thrombosis. Inflammation is closely related to coagulation, and the ability of NETs to promote inflammatoryprogression in NASH may also be related to thrombosis. |
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