| 伏玉洁,赵宁军,卓晓英,等.全身免疫炎症指数和全身炎症反应指数与急性缺血性脑卒中病人神经损伤程度及预后的相关性研究[J].安徽医药,2024,28(12):2372-2377. |
| 全身免疫炎症指数和全身炎症反应指数与急性缺血性脑卒中病人神经损伤程度及预后的相关性研究 |
| Correlation between SII and SIRI with the degree of neurological injury and prognosis in AIS patients |
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| DOI：10.3969/j.issn.1009-6469.2024.12.008 |
| 中文关键词: 脑梗死 卒中 全身免疫炎症指数 全身炎症反应指数 神经损伤 预后 |
| 英文关键词: Brain infarction Stroke Systemic immune inflammatory index Systemic inflammatory response index Nerve injury The prognosis |
| 基金项目:徐州市国家临床重点专科培育项目( 2018ZK004)；徐州市重点研发计划(社会发展)医药卫生面上项目(KC22232，KC22236)；徐州医科大学附属医院第三批优秀中青年人才项目( 2021107408) |
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| 中文摘要: |
| 目的分析急性缺血性脑卒中( AIS)病人的全身免疫炎症指数( SII)和全身炎症反应指数( SIRI)与 AIS病人神经损伤程度及神经功能预后的相关性。方法选取 2021年 12月至 2022年 6月徐州医科大学附属医院急诊科或神经内科收治的 230例 AIS病人作为 AIS组和 150例同期体检人群作为对照组，采血检测血常规，分别收集其血小板、中性粒细胞、单核细胞、淋巴细胞计数，计算 SII、SIRI。记录 AIS病人入院时美国国立卫生研究院卒中量表( NIHSS)评分以及发病 90 d后的改良 Rankin量表(mRS)评分。按 NIHSS评分将病人分为轻度、中度、重度组，比较三组病人的 SII、SIRI是否有差别。按 mRS评分将病人分为预后良好与预后不良组，比较两组病人的 SII、SIRI是否有差别。之后，按照 SII和 SIRI的水平高低进行分组，比较两组之间的 NI-HSS评分和 mRS评分是否有差别。结果 AIS组病人的 SII［523.08(350.24，768.74)×109/L比 373.58(285.90，507.04)×109/L］和 SIRI［1.11(0.71，1.68)×109/L比 0.58(0.40，0.82)×109/L］均较对照组显著升高( P<0.05)。且 AIS组中，重度组 SII和 SIRI较中度组显著升高( P<0.05)中度组的 SII和 SIRI较轻度组显著升高( P<0.05)。90 d后随访，预后不良的 AIS病人 SII和 SIRI均显著高于预后良好的 AIS病人(，P<0.05)。高 SII组病人的 NIHSS评分［8.00(4.00，20.25)分比 3.00(2.00，5.00)分］和 mRS评分［3.00(1.00， 4.75)分比 1.00(0，1.00)分］较低 SII组显著升高( P<0.05)。同样，高 SIRI组病人的 NIHSS评分［8.50(6.00，21.00)分比 3.00(2.00，5.00)分］和 mRS评分［3.00(1.00，5.00)分比 1.00(0，1.25)分］较低 SIRI组显著升高( P<0.05)。结论 AIS病人的 SII和 SIRI均显著升高，且 SII和 SIRI水平越高，卒中病人神经损伤越重，神经功能预后越不良；提示 SII和 SIRI可评估 AIS病人病情严重程度及神经功能预后。 SII、SIRI可能成为提示 AIS病情严重程度及预后的新指标。 |
| 英文摘要: |
| Objective To analyze the correlation of systemic immune inflammatory index (SII) and systemic inflammatory responseindex (SIRI) with the degree of neurological injury and prognosis in patients with acute ischemic stroke (AIS).Methods Totally 230AIS patients,who were admitted to the Emergency Department or Neurology Department of the Affiliated Hospital of Xuzhou MedicalUniversity from December 2021 to June 2022, were chosen as AIS group, and 150 simultaneous physical examination population ascontrol group. Blood was collected and tested for the counts of platelets, neutrophils, lymphocytes and monocytes and SII and SIRI werecalculated. The National Institutes of Health Stroke Scale (NIHSS) score at admission and the modified Rankin Scale (mRS) score atthree months after onset of AIS were recorded.The patients were assigned into light, moderate and serious groups according to NIHSSscore, and the differences in SII and SIRI among the three groups were compared. The patients were assigned into good prognosis groupand poor prognosis group according to mRS score, and the differences in SII and SIRI between the two groups were compared. Then thepatients were assigned into groups according to the levels of SII and SIRI, and the differences in the NIHSS score and mRS score were compared between the two groups.Results Levels of SII [523.08 (350.24,768.74)×109/L vs. 373.58 (285.90,507.04)×109/L] and SIRI [1.11 (0.71,1.68)×109/L vs. 0.58 (0.40,0.82)×109/L] in AIS group were significantly higher than those in control group (P<0.05). In the AIS group, The SII and SIRI levels of severe group were significantly higher than those of moderate group (P<0.05), and SII and SIRI levels in moderate group were significantly higher than those in mild group (P<0.05). After 90 days of follow-up, SII and SIRI levels of AIS patients with poor prognosis were significantly higher than those of AIS patients with good prognosis (P<0.05).The NIHSS scores [8.00 (4.00,20.25) points vs. 3.00 (2.00,5.00) points] and mRS scores [3.00 (1.00,4.75) points vs. 1.00 (0,1.00) points] in the high SII group were significantly higher than those in the low SII group (P<0.05). Similarly, NIHSS scores [8.50 (6.00, 21.00) points vs. 3.00 (2.00,5.00) points] and mRS scores [3.00 (1.00,5.00) points vs. 1.00 (0,1.25) points] of patients in the high SIRI group were significantly higher than those in the low SIRI group (P<0.05).Conclusions SII and SIRI were significantly increased in AIS patients. In addition,the higher the levels of SII and SIRI, the more serious the neurological damage and the worse the prognosis of neurological function instroke patients. It is suggested that SII and SIRI can evaluate the severity and short-term prognosis of AIS patients. SII and SIRI may be new indicators to assist in evaluating the severity and prognosis of AIS. |
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