| 金晓霞,刘玉山,陈鑫焱,等.三阴性乳腺癌中细胞分裂蛋白调节因子 1的表达及新辅助化疗对其表达的影响[J].安徽医药,2024,28(12):2488-2491. |
| 三阴性乳腺癌中细胞分裂蛋白调节因子 1的表达及新辅助化疗对其表达的影响 |
| The expression of PRC1 in triple-negative breast cancer and the impact of neoadjuvant chemotherapy on its expression |
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| DOI：10.3969/j.issn.1009-6469.2024.12.031 |
| 中文关键词: 三阴性乳腺癌 细胞分裂蛋白调节因子 1 新辅助化疗 免疫组织化学 临床病理特征 |
| 英文关键词: Triple-negative breast cancer Protein regulator of cytokinesis 1 Neoadjuvant chemotherapy Immunohistochemistry Clinicopathological features |
| 基金项目:南通市科技计划指令性项目( MS22022015) |
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| 中文摘要: |
| 目的探讨细胞分裂蛋白调节因子 1(PRC1)在三阴性乳腺癌( TNBC)组织中的表达及新辅助化疗对其表达的影响。方法回顾性收集南通大学附属肿瘤医院病理科 2010—2018年存档的、经过手术的乳腺癌病人组织，利用免疫组织化学 EnVision法检测 PRC1在 55例正常乳腺组织、 49例腔面型乳腺癌、 40例人表皮生长因子受体 2(HER-2)过表达型乳腺癌及 40例 TNBC样本中的表达，比较各组别中 PRC1的表达差异。统计分析 PRC1的表达水平与 TNBC临床病理参数之间的相关性。比较 TNBC新辅助化疗前后 PRC1的表达变化。结果 PRC1在正常乳腺组织、腔面型乳腺癌、 HER-2过表达型乳腺癌、 TNBC中的阳性表达率分别为 7.27%(4/55)、 30.61%(15/49)、 32.50%(13/40)和 95.00%(38/40)。 PRC1在 TNBC中的阳性表达率显著高于其他类型( P<0.017)并且与脉管侵犯和淋巴结转移具有正相关性( P<0.05)。新辅助化疗后， TNBC中 PRC1的表达明显下降，降为 52.50%(21/40结论 PRC1在 TNBC中的表达明显高于其他类型乳腺癌，并与其脉管侵犯、淋巴结转移呈正相关，新辅助化)。，疗可以显著降低 PRC1的表达。因此， PRC1有望成为 TNBC诊断和防治的新靶点。 |
| 英文摘要: |
| Objective To explore the expression of protein regulator of cytokinesis 1 (PRC1) in triple-negative breast cancer (TNBC) tissues, and the effect of neoadjuvant chemotherapy on its expression.Methods Tissues of breast cancer patients undergoing surgery,archived in Department of Pathology, Affiliated Cancer Hospital of Nantong University from 2010 to 2018, were retrospectively collect-ed. The expressions of PRC1 in 55 normal breast tissue, 49 cases of luminal type breast cancer, 40 cases of human epidermal growthfactor receptor 2 (HER-2) overexpressing breast cancer and 40 TNBC samples were detected by an immunohistochemical staining tech-nique the EnVision method, and the differences in PRC1 expression between groups were compared. The correlation between the ex-pression level of PRC1 and the clinicopathological parameters of TNBC was statistically analyzed, and the changes of PRC1 expressionbefore and after neoadjuvant chemotherapy in TNBC were compared.Results The positive expression rates of PRC1 in normal breast tissue, luminal type breast cancer, HER-2 overexpressing breast cancer, and TNBC were 7.27% (4/55), 30.61% (15/49), 32.50% (13/40), and 95.00% (38/40). The positive expression rate of PRC1 in TNBC was significantly higher than that in other types (P<0.017), and positively correlated with vascular invasion and lymph node metastasis (P<0.05). After neoadjuvant chemotherapy for TNBC, theexpression of PRC1 was significantly reduced, with a positive expression rate dropping to 52.50% (21/40).Conclusions The expres-sion of PRC1 in TNBC was significantly higher than that in other types of breast cancer and had a positive correlation with its vascularinvasion and lymph node metastasis, and neoadjuvant chemotherapy significantly reduced the expression of PRC1. Therefore, PRC1 isexpected to be a new target for the diagnosis and prevention of TNBC. |
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