| 裘艺莎,吴锴,胡剑,等.全身免疫炎症指数在儿童紫癜性肾炎中的预测价值[J].安徽医药,2024,28(12):2497-2501. |
| 全身免疫炎症指数在儿童紫癜性肾炎中的预测价值 |
| Predictive value of systemic immune-inflammation index in children with Henoch-Sch.nlein purpura nephritis |
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| DOI：10.3969/j.issn.1009-6469.2024.12.033 |
| 中文关键词: 过敏性紫癜性肾炎 全身免疫炎症指数 红细胞体积分布宽度 中性粒细胞计数 /淋巴细胞计数比值 儿童 |
| 英文关键词: Hypersensitive purpura nephritis Systemic immune-inflammation index Red cell volume distribution width Neutro-phil to lymphocyte ratio Children |
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| 中文摘要: |
| 目的探讨全身免疫炎症指数( SII)对儿童紫癜性肾炎( HSPN)的预测价值。方法选取 2019年 6月至 2022年 12月于南京医科大学附属淮安第一医院住院治疗的 161例过敏性紫癜病儿为研究对象，根据中华医学会儿科学分会肾脏病学组 2016版 HSPN诊治循证指南中 HSPN的诊断标准分为非肾炎组 95例和肾炎组 66例，应用多因素 logistic回归分析 HSPN的独立危险因素； Spearman相关性分析检验 SII与 HSPN病理分级严重程度的相关性；利用受试者操作特征曲线( ROC曲线)评估 SII对 HSPN的预测价值。结果肾炎组 SII水平显著高于非肾炎组［792.30(472.58，1 428.01)×109/L比 501.41(311.97，962.26)×109/L，Z=.3.07，P=0.002］，不同病理级别肾炎组间 SII水平差异有统计学意义( Z=.3.21，P=0.001)； SII［OR=1.002，95%CI:(1.000， 1.004)P=0.038］是 HSPN的独立危险因素； SII水平与 HSPN病理分级严重程度呈正相关( r=0.54，P<0.001)； SII预测 HSPN的曲线下为 0.64［95%CI:(0.56，0.73)P=0.002］最佳截断值为 390.03×109/L，灵敏度和特异度分别为 83.31%和 43.20%。结面积，论 SII对预测HSPN及评估病理严重程度，有一定的，临床应用价值。 |
| 英文摘要: |
| Objective To investigate the predictive value of systemic immune-inflammation index (SII) for Henoch-Sch.nlein purpu-ra nephritis (HSPN) in children.Methods A total of 161 children with Henoch-Sch.nlein purpura who were hospitalized in The Affili-ated Huai'an No.1 People's Hospital of Nanjing Medical University from June 2019 to December 2022 were selected as the researchobjects. According to the diagnostic criteria of HSPN in the 2016 evidence-based Guidelines for the Diagnosis and Treatment of purpu-ra nephritis, Nephrology Group, Branch of the Chinese Medical Pediatrics Society, the patients were divided into non-nephritis group (n= 95) and nephritis group (n=66). Multivariate logistic regression analysis was used to analyze the independent risk factors of HSPN.Spearman correlation analysis was used to analyze the correlation between SII and the severity of pathological grading of HSPN. The re-ceiver operating characteristic (ROC) curve was used to evaluate the predictive value of SII for HSPN.Results The level of SII in ne-phritis group was significantly higher than that in non-nephritis group [792.30 (472.58,1 428.01)×109/L vs. 501.41 (311.97,962.26)×109/L, Z=.3.07, P=0.002], and the level of SII has statistical difference between nephritis groups with different pathological grades (Z= .3.21, P=0.001); SII [OR=1.002, 95% CI: (1.000, 1.004), P=0.038] was an independent risk factor for HSPN;SII level was positivelycorrelated with the severity of pathological grading of HSPN (r=0.54, P < 0.001);The area under the curve of SII for predicting HSPN was 0.64 [95% CI: (0.56, 0.73), P=0.002], and the best cut-off value was 390.03×109/L, the corresponding sensitivity and specificity were 83.31% and 43.20% respectively.Conclusion SII has clinical value in predicting HSPN and evaluating the pathological severity. |
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