| 李杏红,李衡.赖氨肌醇维 B12联合复方消化酶对功能性消化不良病儿胃肠动力、营养指标、胰岛素样生长因子 Ⅰ水平的作用[J].安徽医药,2024,28(12):2520-2525. |
| 赖氨肌醇维 B12联合复方消化酶对功能性消化不良病儿胃肠动力、营养指标、胰岛素样生长因子 Ⅰ水平的作用 |
| Effects of lysine, inosite and vitamin B12 oral solution combined with compound digestive enzyme capsules on gastrointestinal motility, nutritional indices, and insulin-like growth factor Ⅰ levels in children with functional dyspepsia |
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| DOI：10.3969/j.issn.1009-6469.2024.12.037 |
| 中文关键词: 消化不良 复方消化酶 赖氨肌醇维 B12 胃肠动力学 5-羟色胺 胰岛素样生长因子 Ⅰ 免疫球蛋白 |
| 英文关键词: Dyspepsia Compound digestive enzyme Rayinositol vitamin B12 Gastrointestinal dynamics 5-hydroxytrypta-mine Insulin-like growth factor Ⅰ Immunoglobulin |
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| 中文摘要: |
| 目的探讨赖氨肌醇维 B12联合复方消化酶对功能性消化不良( FD)病儿胃肠动力、营养指标、胰岛素样生长因子 Ⅰ(IGF-Ⅰ)水平的影响。方法根据治疗方案不同将 2021年 2月至 2023年 2月商丘市第三人民医院收治的 84例 FD病儿分为两组，各 42例。对照组予以复方消化酶治疗，观察组予以赖氨肌醇维 B12联合复方消化酶治疗，均治疗 4周。观察两组疗效、不良反应及治疗前后胃肠动力学指标、胃肠激素［胃动素、生长抑素( SS)］及 5-羟色胺( 5-HT)水平、营养指标［前白蛋白( PA)、蛋白、转铁蛋白( TRF)］免疫指标［免疫球蛋白( Ig)A、IgG、IgM］及 IGF-Ⅰ水平变化。结果观察组总有效率 97.62%(41/42)较白对照组 80.95%(34/42)高(、P<0.05)；治疗 2周、 4周后观察组胃窦收缩幅度［治疗 2周后:(51.65±5.00)mm比( 48.32±3.85)mm］、胃窦收缩频率、餐后 3h胃排空率、餐后 3h肠排空率均高于对照组( P<0.05)；治疗 2周、 4周后观察组胃动素、 5-HT水平较对照组升高， SS水平较对照组降低(P<0.05)；治疗 2周、 4周后观察组血清白蛋白［治疗 2周后:(39.20±4.13)g/L比(36.68±5.65)g/L］、 PA、TRF、IGF-Ⅰ［治疗 2周后:(112.57±14.20)μg/L比( 76.12±11.58)μg/L］水平高于对照组( P<0.05)；治疗 2周、 4周后观察组 IgA、IgG、IgM水平高于对照组( P<0.05)；两组不良反应发生率比较差异无统计学意义( P>0.05)。结论赖氨肌醇维 B12联合复方消化酶能改善 FD病儿胃肠动力，调节胃肠道激素水平，改善病儿营养状态，提高机体免疫水平，效果确切。 |
| 英文摘要: |
| Objective To investigate the effects of lysine, inosite and vitamin B12 oral solution combined with compound digestive en-zyme capsules on gastrointestinal motility, nutritional indices, and insulin-like growth factor Ⅰ (IGF-Ⅰ) levels in children with func-tional dyspepsia (FD).Methods Eighty-four children with FD admitted to The Third People's Hospital of Shangqiu City from February2021 to February 2023 were assigned into two groups, 42 cases in each group, according to different therapies. The control group wastreated with compound digestive enzyme capsules, while the observation group was treated with lysine, inosite and vitamin B12 oral solu-tion combined with compound digestive enzyme capsules, both for 4 weeks. The efficacies and adverse reactions of the two groups wereobserved, as well as the changes in gastrointestinal dynamics, gastrointestinal hormones [motilin, somatostatin (SS)], 5-hydroxytrypta-mine (5-HT) levels, nutritional indices [prealbumin (PA), albumin (ALB), transferrin (TRF)], immune indicators [immunoglobulin (Ig)A, IgG, IgM], and IGF-Ⅰ levels before and after treatment.Results The total effective rate of the observation group was 97.62% (41/42), which was higher than that of the control group (80.95%, 34/42). After 2 and 4 weeks of treatment, the observation group had high-er gastric antral contraction amplitude [after 2 weeks of treatment: (51.65±5.00) mm vs. (48.32±3.85) mm], gastric antral contraction fre-quency, 3-hour postprandial gastric emptying rate, and 3-hour postprandial intestinal emptying rate than the control group (P<0.05), and the observation group had higher levels of motilin and 5-HT and lower levels of SS than the control group (P<0.05). After 2 and 4 weeks of treatment, the serum levels of ALB [after 2 weeks of treatment: (39.20±4.13) g/L vs. (36.68±5.65) g/L], PA, TRF, and IGF-Ⅰ [after 2 weeks of treatment: (112.57±14.20) μg/L vs. (76.12±11.58) μg/L] in the observation group were higher than those in the control group (P<0.05); the levels of IgA, IgG, and IgM in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion lysine, inosite and vi-tamin B12 oral solution combined with compound digestive enzyme capsules can improve gastrointestinal motility in children with FD,regulate gastrointestinal hormone levels, improve nutritional status, and enhance immune function, with a confirmed effect. |
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