| 刘沁爽,李兆恒,刘爽,等.老年肥胖病人顺式阿曲库铵按去脂体质量给药对其 95%有效剂量的影响[J].安徽医药,2024,28(12):2525-2529. |
| 老年肥胖病人顺式阿曲库铵按去脂体质量给药对其 95%有效剂量的影响 |
| The effect of cisatracurium administered according to fat-free body mass on 95% effective dose in elderly obese patients |
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| DOI：10.3969/j.issn.1009-6469.2024.12.038 |
| 中文关键词: 阿曲库铵 剂量 肥胖 老年人 去脂体质量 95%有效剂量 肌纤维颤搐 |
| 英文关键词: Atracurium Dosage Obesity Aged Fat-free mass ED95 Myokymia |
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| 中文摘要: |
| 目的观察老年肥胖病人顺式阿曲库铵按去脂体质量( FFM)给药对其 95%有效剂量( ED95)的影响。方法选择 2020年 9月 20日至 2021年 9月 30日在秦皇岛市第一医院择期行全麻手术老年(年龄 ≥65岁)肥胖病人 40例。根据随机数字表法分为 OF1~OF4组，每组 10例(男女各 5例)采用单次剂量法按 FFM分别给予 40、50、60、70 μg/kg的顺式阿曲库铵，给药后使用 Mindray BeneVision N17型监护仪进行肌松，监测，记录拇内收肌第 1个肌颤搐反应( T1)最大抑制值及起效时间，对顺式阿曲库铵单次剂量进行对数转换，将 T1最大抑制值进行概率单位转换，用直线回归方法建立量效曲线，计算其 ED95。结果 T1最大抑制值随剂量的增加而增大( P<0.05)，得出 ED95为 70.5 μg/kg。结论老年肥胖病人按 FFM给予顺式阿曲库铵的 ED95为 70.5 μg/kg。 |
| 英文摘要: |
| Objective To evaluate the effect of cisatracurium administered according to fat-free body mass (FFM) on 95% effective dose in elderly obese patients.Methods A total of 40 elderly obese patients (age≥65) were selected to undergo elective general anes-thesia surgery at the First Hospital of Qinhuangdao City from September 20, 2020, to September 30, 2021. Utilizing the random numbertable method, participants were allocated into four groups (OF1 to OF4), with ten patients in each group (five males and five females). Asingle-dose administration of cis-atracurium was tailored according to fat-free mass (FFM), with respective doses of 40, 50, 60, and 70μg/kg. Following drug administration, muscle relaxation was monitored using the Mindray BeneVision N17 monitor; we recorded boththe maximum inhibition value of the medial digit flexor muscle (T1) and the onset time. The single-dose cis-atracurium data were loga-rithmically transformed while T1 maximum inhibition values underwent probability unit conversion. A linear regression analysis wasemployed to establish a dose-response curve from which ED95 was calculated.Results The maximum inhibitory value of T1 exhibited a significant increase with the dose escalation (P<0.05). The ED95 was determined to be 70.5 μg/kg.Conclusion The ED95 values of cis-atracurium in aged obesity patients, administered based on FFM, were determined to be 70.5 μg/kg. |
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