| 李会,于鹏杰,杨捷,等.磷酸蛋白酶 1基因在恶性肿瘤中的作用及其研究进展[J].安徽医药,2025,29(1):1-6. |
| 磷酸蛋白酶 1基因在恶性肿瘤中的作用及其研究进展 |
| The role of SPP1 gene in malignant tumors and its research progress |
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| DOI：10.3969/j.issn.1009-6469.2025.01.001 |
| 中文关键词: 骨桥蛋白质 磷酸蛋白酶 1 肿瘤 免疫抑制 肿瘤标志物 耐药 |
| 英文关键词: Osteopontin Secreted phosphoprotein 1 Neoplasma Immunosuppressions Biomarkers-tumor Chemoresistance |
| 基金项目:青海省“昆仑英才 ·高端创新创业人才项目(青人才字〔2024〕1号)；青海大学附属医院中青年科研基金项目( ASRF-2024-YB-05) |
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| 摘要点击次数: 2049 |
| 全文下载次数: 288 |
| 中文摘要: |
| 磷酸蛋白酶 1(SPP1)是糖蛋白家族成员之一，广泛表达于肺腺癌、胃癌、食管鳞状细胞癌等肿瘤组织，在多种肿瘤中具有生物标志物的特性。 SPP1通过与配体相互作用，影响下游信号通路，使肿瘤免疫微环境处于抑制状态，从而介导多种恶性肿瘤生长、浸润和转移； SPP1亦可通过磷脂酰肌醇 3-激酶( PI3K)/蛋白激酶 B(AKT)信号通路介导卵巢癌、肝细胞癌出现耐药，而研究表明 SPP1抑制剂可以逆转肿瘤耐药，减慢肿瘤发展过程。 SPP1有希望成为恶性肿瘤潜在的诊断治疗靶点之一，该研究就 SPP1基因在恶性肿瘤研究中进展作一综述。 |
| 英文摘要: |
| Secreted phosphoprotein 1 (SPP1), a member of the glycoprotein family, is extensively expressed in lung adenocarcinoma,gastric cancer, esophageal squamous cell carcinoma, and other tumor tissues, and possesses biomarker properties in a multitude of tu-mors. By interacting with ligands, SPP1 influences the downstream signaling pathway and impedes the tumor immune microenviron-ment, thereby facilitating the growth, invasion, and metastasis of various malignant tumors. SPP1 is also capable of mediating drug resis-tance in ovarian cancer and other forms of cancer. Additionally, SPP1 can also mediate drug resistance in ovarian cancer and hepatocel-lular carcinoma through the phosphoinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. Studies have demonstrated thatSPP1 inhibitors can reverse tumor drug resistance and slow down tumor progression. SPP1 possesses the potential to be among the via-ble targets for the diagnosis and treatment of malignant tumors. This study reviews the progress of SPP1 gene research in malignant tu-mors. |
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