| 费良,刘红霞,赵敬贤,等.血清 IL-6R和 IL-22表达与溃疡性结肠炎严重程度及临床结局的关系[J].安徽医药,2025,29(1):48-52. |
| 血清 IL-6R和 IL-22表达与溃疡性结肠炎严重程度及临床结局的关系 |
| Relationship between the expression of serum IL-6R and IL-22 and the severity and clinical outcome of ulcerative colitis |
| |
| DOI：10.3969/j.issn.1009-6469.2025.01.009 |
| 中文关键词: 结肠炎，溃疡性 白细胞介素 -6受体 白细胞介素 -22 病情严重程度 临床结局 |
| 英文关键词: Colitis, ulcerative Interleukin-6 receptor Interleukin-22 Severity of the condition Clinical outcomes |
| 基金项目:湖北省自然科学基金( WJ2019AB085) |
|
| 摘要点击次数: 692 |
| 全文下载次数: 251 |
| 中文摘要: |
| 目的探究血清白细胞介素 -6受体( IL-6R)和白细胞介素 -22(IL-22)表达与溃疡性结肠炎严重程度及临床结局的关系。方法选取监利市人民医院 2017年 12月至 2022年 6月治疗的 212例溃疡性结肠炎病人为研究对象，根据其病情严重程度分为轻症组与重症组，根据治疗 2个月的预后情况分为预后良好组与预后不良组，采用酶联免疫吸附测定检测 IL-6R、IL-22水平并收集病人临床资料， logistic多因素回归分析影响溃疡性结肠炎病人预后的相关因素；绘制受试者操作特征曲线( ROC曲线)预测 IL-6R和 IL-22对溃疡性结肠炎严重程度以及预后的临床诊断及预测价值。结果与轻症组［(11.10±1.21)ng/L、(50.24±6.35)ng/L］相比，重症组在入院时的血清 IL-6R［(15.32±2.62)ng/L］、 IL-22水平［(63.61±6.95)ng/L］显著增加( P<0.05)，通过绘制 ROC曲线发现 IL-6R、IL-22以及两者联合诊断重症溃疡性结肠炎的曲线下面积( AUC)分别为 0.85、0.85、0.92，并且二者联合诊断显著优于 IL-6R、IL-22单独诊断( Z=3.58，3.42；P=0.003，0.006)；通过分析病人一般临床资料发现，溃疡性结肠炎病人的预后与病人是否有肠外表现、 C反应蛋白(CRP)降钙素原(PCT)红细胞沉降率(ESR)粪便钙卫蛋白(FC)、粪便乳铁蛋白(FL)、IL-6R以及 IL-22水平有关( P<0.05)，与性别、关( P>0.05)istic多因素回归发现， CRP、PCT、ESR、FC、FL、IL-6R以及 IL-22均为影响溃疡性结肠炎病人预后的危险因素( P<0.05制 ROC曲线发现 IL-6R、IL-22以及两者联合预测溃疡性结肠炎年龄无、log、分析、)。绘病人预后的 AUC分别为 0.81、0.83、0.90，并且二者联合预测显著优于 IL-6R、IL-22单独预测( Z=3.70，3.18；P<0.001，P=0.002)。结论溃疡性结肠炎病人血清 IL-6R、IL-22水平随病人病情严重程度增加，均为影响溃疡性结肠炎病人预后的危险因素，并且对病人的病情严重程度及临床结局预测具有辅助诊断价值。 |
| 英文摘要: |
| Objective To explore the relationship between the expression of serum interleukin-6 receptor (IL-6R) and interleukin-22 (IL-22) and the severity and clinical outcome of ulcerative colitis.Methods Two hundred and twelve patients with ulcerative colitis treated in Jianli People's Hospital from December 2017 to June 2022 were as research objects, according to the severity of their condi-tion, they were grouped into mild and severe group, according to the prognosis after 2 months of treatment, they were grouped into agood prognosis group and a poor prognosis group, enzyme linked immunosorbent assay (ELISA) was applied to detect IL-6R and IL-22 levels, and clinical data were collected from patients, Logistic regression was applied to analyze the related factors affected the progno-sis of patients with ulcerative colitis; receiver operating characteristic was drawn to predict the clinical diagnostic and predictive valueof IL-6R and IL-22 for severity and prognosis of ulcerative colitis.Results Compared with the mild group [(11.10±1.21) ng/L, (50.24± 6.35) ng/L], the serum levels of IL-6R [(15.32±2.62) ng/L] and IL-22 [(63.61±6.95) ng/L] in the severe group were obviously increased at admission (P<0.05), by drawing the receiver operating characteristic, it was found that the AUC of IL-6R, IL-22 and their combined diagnosis of severe ulcerative colitis was 0.85, 0.85 and 0.92, respectively, and their combined diagnosis was obviously better than thatof IL-6R and IL-22 alone (Z=3.58, 3.42; P=0.003, 0.006); by analyzing the general clinical data of the patients, it was found that theprognosis of patients with ulcerative colitis was related to whether they had extraintestinal manifestations, C-reactive protein (CRP), pro-cal.citonin (PCT), erythrocytesedimentrate (ESR), faecal calreticulin (FC), faecal lactoferrin (FL), IL-6R and IL-22 levels (P<0.05), but not to gender and age (P>0.05), multiple Logistic regression analysis showed that CRP, PCT, ESR, FC, FL, IL-6R and IL-22 were all risk factors affecting the prognosis of ulcerative colitis patients (P<0.05). Receiver operating characteristic found that the AUC of pa-tients with ulcerative colitis predicted by IL-6R, IL-22 and their combination was 0.81, 0.83 and 0.90, respectively, and their combinedpredicted was obviously better than that predicted by IL-6R and IL-22 alone (Z=3.70, 3.18; P<0.001, P=0.002).Conclusion The serum levels of IL-6R and IL-22 in patients with ulcerative colitis increase with the severity of the patient's disease, both are both risk factorsaffecting the prognosis of patients with ulcerative colitis, and they have an auxiliary diagnostic value in the prediction of the severity ofthe patient's disease and clinical outcome. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
