| 范彩逢,郭玉冰,齐玉婕.血清网膜素 -1和血管生成素样蛋白 2水平与心房颤动病人射频消融术后复发的相关性研究[J].安徽医药,2025,29(1):100-104. |
| 血清网膜素 -1和血管生成素样蛋白 2水平与心房颤动病人射频消融术后复发的相关性研究 |
| Correlation between serum Omentin-1 and ANGPTL2 levels and relapse in patients with atrial fibrillation after radiofrequency ablation |
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| DOI：10.3969/j.issn.1009-6469.2025.01.020 |
| 中文关键词: 心房颤动 射频消融术 网膜素 -1 血管生成素样蛋白 2 复发 |
| 英文关键词: Atrial fibrillation Radiofrequency ablation Omentin-1 Angiopoietin like protein 2 Recurrence |
| 基金项目:河南省医学科技攻关项目( LHGJ20220934) |
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| 中文摘要: |
| 目的探究血清网膜素 -1(Omentin-1)和血管生成素样蛋白 2(ANGPTL2)水平与心房颤动( AF)病人射频消融术后复发的相关性。方法选取 2021年 1月至 2022年 1月在郑州大学附属洛阳中心医院实施射频消融术治疗的 125例 AF病人，依据随访结果分为两组:未复发组(n=93)、复发组( n=32)；血清 Omentin-1、ANGPTL2、白细胞介素( IL)-6、IL-8、肿瘤坏死因子 α(TNF-α)水平行酶联免疫吸附测定( ELISA)； AF病人术后血清 Omentin-1、ANGPTL2水平与各指标相关性采用 Pearson分析；多因素 logistic分析 AF病人术后复发影响因素；采用受试者操作特征曲线( ROC曲线)评价血清 Omentin-1、ANGPTL2水平在预测 AF病人术后复发中的价值。结果复发组血清 IL-6［(3.56±0.73)ng/L］、 IL-8［(8.26±2.58)ng/L］、 TNF-α［(7.34±2.19)ng/L］左心房内径( LAD)水平［( 37.24±5.23)mm］较未复发组［( 1.41±0.26)ng/L、(3.49±1.04)ng/L、(2.67±0.63)ng/L、(31.44±4.16)mm］均、显著升高， LVEF水平较未复发组显著降低( P<0.05)；与未复发组比较，复发组血清 Omentin-1水平显著降低，复发组血清 ANGPTL2上水平显著升高( P<0.05)； Pearson分析显示， AF病人术前血清 Omentin-1水平与炎症因子 IL-6、IL-8、TNF-α及 LAD均呈负相关，与 LVEF呈正相关( P<0.05)；血清 ANGPTL2水平与炎症因子 IL-6、IL-8、TNF-α及 LAD水平均呈正相关，与 LVEF呈负相关(P<0.05)且 Omentin-1、ANGPTL2水平呈负相关；多因素 logistic分析显示，高水平 Omentin-1为 AF病人术后复发的独立保护因素，高水平，ANGPTL2、IL-6、IL-8均为 AF病人术后复发的独立危险因素( P<0.05)； ROC曲线分析显示，血清 Omentin-1、ANG-PTL2水平预测 AF病人术后复发的曲线下面积( AUC)分别为 0.88、0.84，两者联合预测的 AUC为 0.94，效能均优于两者单独预测(Z=1.93、2.10，P<0.05)。结论 AF病人术后血清 Omentin-1水平显著降低，血清 ANGPTL2水平显著升高，与术后复发相关，且两者联合对预测 AF术后复发具有一定价值。 |
| 英文摘要: |
| Objective To investigate the correlation between serum levels of omentin-1 and angiopoietin-like protein 2 (ANGPTL2) and recurrence after radiofrequency ablation in patients with atrial fibrillation (AF).Methods A total of 125 AF patients were selectedto undergo radiofrequency ablation in Zhengzhou University Affiliated Luoyang Central Hospital from January 2021 to January 2022,and were divided into 2 groups according to follow-up results: no recurrence group (n=93) and recurrence group (n=32); enzyme linked immunosorbent assay (ELISA) was applied to measure serum levels of Omentin-1, ANGPTL2, interleukin (IL)-6, IL-8, and tumor necro-sis factor-α (TNF-α); Pearson was applied to analyze the correlation between serum levels of Omentin-1 and ANGPTL2 and various in-dicators in patients with atrial fibrillation after radiofrequency ablation; multivariate Logistic regression was applied to analyze the influ-encing factors of recurrence in patients with atrial fibrillation after radiofrequency ablation; receiver operating characteristic curve(ROC curve) was applied to evaluate the value of serum Omentin-1 and ANGPTL2 levels in predicting recurrence in patients with atrial fibrillation after radiofrequency ablation.Results The serum levels of IL-6 [(3.56±0.73) ng/L], IL-8 [(8.26±2.58) ng/L], TNF-α [(7.34±2.19) ng/L], and left atrial diameter (LAD) [(37.24±5.23) mm] in the recurrent group were obviously higher than those in the non recur-rent group [(1.41±0.26) ng/L, (3.49±1.04) ng/L, (2.67±0.63) ng/L, (31.44±4.16) mm], while LVEF level was obviously lower than that inthe non recurrent group (P<0.05); compared with the non recurrent group , the serum Omentin-1 level in the recurrent group was obvi-ously reduced, while the serum ANGPTL2 level in the recurrent group was obviously increased (P<0.05); Pearson analysis showed that the serum level of Omentin-1 in patients with atrial fibrillation before radiofrequency ablation was negatively correlated with inflamma-tory factors IL-6, IL-8, TNF-α, and LAD, and positively correlated with LVEF (P<0.05); the level of serum ANGPTL2 was positively correlated with inflammatory factors IL-6, IL-8, TNF-α, and LAD, while negatively correlated with LVEF (P<0.05), and Omentin-1 and ANGPTL2 levels were negatively correlated; multivariate logistic regression analysis showed that high level of Omentin-1 was indepen-dent protective factor for recurrence in patients with atrial fibrillation after radiofrequency ablation, while high levels of ANGPTL2, IL-6, and IL-8 were independent risk factors for recurrence in patients with atrial fibrillation after radiofrequency ablation (P<0.05); ROC curve analysis showed that the area under the curve (AUC) predicted by serum levels of Omentin-1 and ANGPTL2 for recurrence in pa-tients with atrial fibrillation after radiofrequency ablation was 0.88 and 0.84, respectively, the AUC predicted by the combination of thetwo was 0.94, with better efficacy than that predicted by the two alone (Z=1.93 and 2.10, P<0.05).Conclusion The serum Omentin-1 level in patients with atrial fibrillation obviously decreases after radiofrequency ablation, the serum ANGPTL2 level obviously increas-es, they are related to postoperative recurrence, and the combination of the two has certain value in predicting the recurrence of atrial fi-brillation after radiofrequency ablation. |
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