| 贾雪,张云淑,张丽丽,等.伴失眠症状老年抑郁症病人血清神经营养因子及甲状腺激素水平变化[J].安徽医药,2025,29(1):109-113. |
| 伴失眠症状老年抑郁症病人血清神经营养因子及甲状腺激素水平变化 |
| Changes of neurotrophic factor and thyroid hormone levels in elderly depressed patients with insomnia symptoms |
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| DOI：10.3969/j.issn.1009-6469.2025.01.022 |
| 中文关键词: 抑郁症 入睡和睡眠障碍 脑源性神经营养因子 胶质源性神经营养因子 甲状腺激素 老年人 |
| 英文关键词: Depression Sleep initiation and maintenance disorders Brain-derived neurotrophic factor Glial-derived neurotroph-ic factor Thyroid hormone Aged |
| 基金项目:河北省财政厅老年病防治项目( 361014) |
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| 中文摘要: |
| 目的探讨伴失眠症状老年抑郁症病人脑源性神经营养因子( brain-derived neurotrophic factor，BDNF)、胶质源性神经营养因子( glial cell line-derived neurotrophic factor，GDNF)、甲状腺激素( thyroid hormone，TH)水平变化。方法回顾性分析于 2016年 7月至 2018年 3月河北省第六人民医院收治的 124例老年抑郁病人年的临床资料，根据有无失眠症状分为伴失眠症状组 65例、无失眠症状组 59例。比较两组血清 BDNF、GDNF、TH水平差异，并对老年抑郁症失眠的影响因素进行分析。结果伴失眠症状组 BDNF水平低于无失眠症状组［ 981.09(924.37，1 031.63)ng/L，1 062.64(1 012.79，1 137.61)ng/L］，差异有统计学意义( P<0.05)。伴失眠症状组 GDNF水平低于无失眠症状组［ 0.41(0.31，0.50)ng/L，0.56(0.44，0.69)ng/L］差异有统计学意义(P<0.05)。相比于无眠症状组，伴失眠症状组三碘甲状腺原氨酸( T3)、甲状腺素( T4)、游离三碘甲状腺原氨，酸( FT3)、游离甲状腺激素( FT4)表达水平及促甲状腺激素( TSH)表达水平，差异无统计学意义( P>0.05)。此外相关性分析显示， BDNF、GDNF水平之间呈正相关( P<0.05)。二元 logistic回归分析结果表明血清 BDNF、GDNF是伴发失眠症状的保护因素( BDNF:OR=0.99； GDNF:OR=0.01)。结论提高血清 BDNF和 GDNF水平至正常水平可能成为改善老年抑郁失眠的潜在途径。 |
| 英文摘要: |
| Objective To investigate the changes in the levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and thyroid hormone (TH) in elderly patients with comorbid insomnia symptoms and depression. Methods The clinical data of 124 patients with depression admitted to The Sixth Clinical Medical College of Hebei University from July 2016 toMarch 2018 were retrospectively analyzed. The patients were divided into two groups: a group with comorbid insomnia symptoms (n= 65) and a group without insomnia symptoms (n=59). The differences in serum BDNF, GDNF, and TH levels were compared between thetwo groups, and the factors influencing insomnia in elderly depression were analyzed.Results The levels of BDNF in patients with in-somnia were significantly lower than those without insomnia [981.09 (924.37,1 031.63) ng/L, 1 062.64 (1 012.79,1 137.61) ng/L, P< 0.05]. The levels of GDNF in patients with insomnia were significantly lower than those without insomnia[0.41 (0.31,0.50) ng/L, 0.56(0.44,0.69) ng/L, P<0.05, P<0.05]. Compared with the insomnia group, the expression levels of triiodothyronine (T3) , thyroxine (T4) ,free triiodothyronine (FT3) , free Thyroid hormone (FT4) and thyroid-stimulating hormone (TSH) in patients with insomnia, there was no statistical significance (P>0.05). In addition, there was a strong correlation between the levels of BDNF and GDNF (P<0.05). Multiple Logistic regression analysis showed that serum BDNF and GDNF were protective factors of insomnia (BDNF: OR = 0.991; GDNF: OR = 0.008) .Conclusion Elevating serum BDNF and GDNF levels to normal ranges can potentially serve as a promising avenue for im-proving insomnia in elderly patients with depression. |
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