| 张明华,安亚琴,孙丽静,等.血清游离脂肪酸和心型脂肪酸结合蛋白表达与 2型糖尿病病人动脉粥样硬化斑块的关系研究[J].安徽医药,2025,29(1):151-155. |
| 血清游离脂肪酸和心型脂肪酸结合蛋白表达与 2型糖尿病病人动脉粥样硬化斑块的关系研究 |
| Study on the relationship between the expression of serum free fatty acid and heart type fatty acid binding protein and atherosclerotic plaque in type 2 diabetes patients |
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| DOI：10.3969/j.issn.1009-6469.2025.01.031 |
| 中文关键词: 糖尿病， 2型 斑块，动脉粥样硬化 游离脂肪酸 心型脂肪酸结合蛋白 相关性 诊断 |
| 英文关键词: Diabetes mellitus, type 2 Plaque,atherosclerotic Free fatty acid Heart type fatty acid binding protein Correla-tion Diagnosis |
| 基金项目:保定市科技局课题项目( 2241ZF022) |
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| 摘要点击次数: 454 |
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| 中文摘要: |
| 目的探讨血清游离脂肪酸( FFA)和心型脂肪酸结合蛋白(H-FABP)表达与 2型糖尿病( T2DM)病人动脉粥样硬化斑块(CAP)的关系研究。方法选取 2020年6月至 2022年6月保定市第四中心医院接收的 T2DM病人 302例为研究对象。通过颈动脉超声检查进一步将研究对象分为 CAP组(165例)和无 CAP组(137例)。采用酶联免疫吸附测定(ELISA)检测血清 FFA、H-FABP水平；采用 logistic多因素回归分析 CAP发生的影响因素；采用 Spearman法分析血清 FFA、H-FABP水平及与临床资料的相关性分析；采用受试者操作特征曲线( ROC曲线)评价血清 FFA、H-FABP及其联合对 CAP发生的诊断效能。结果相较于无 CAP组， CAP组年龄、高血压史、 C反应蛋白( CRP)、三酰甘油( TG)、低密度脂蛋白胆固醇( LDL)、载脂蛋白 A(ApoA)、 FFA、H-FABP［(4.63±1.43)μg/L比( 3.68±1.05)μg/L］水平显著上升( P<0.05)，LPa水平显著下降( P<0.05)。 logistic分析显示，年龄、 CRP、TG、 LDL、FFA、H-FABP均是 T2DM病人 CAP发生的独立危险因素(P<0.05)。 T2DM合并 CAP病人血清 FFA与 H-FABP、年龄、 CRP、 TG、LDL水平呈正相关( rs=0.61、0.59、0.52、0.57、0.55，P<0.05)。血清 H-FABP与年龄、 CRP、TG、LDL水平呈正相关( rs=0.58、 0.53、0.57、0.54，P<0.05)。 ROC曲线结果显示血清中 FFA、H-FABP水平及二者联合预测 T2DM病人 CAP发生的 AUC分别为 0.71、0.74、0.84，其中联合预测 AUC显著高于二者单独预测 AUC(Z=3.65、2.68，P<0.05)。结论 FFA、H-FABP水平在 T2DM合并 CAP病人血清中升高，与年龄、 CRP、TG、LDL关系密切，均有望成为 T2DM病人 CAP发生的诊断因子。 |
| 英文摘要: |
| Objective To investigate the relationship between the expression of serum free fatty acid (FFA) and heart type fatty acid binding protein (H-FABP) and atherosclerotic plaque (CAP) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 302 patients with T2DM admitted to the fourth Central Hospital of Baoding from June 2020 to June 2022 were selected as the research ob-jects. The subjects were further grouped into CAP group (165 cases) and non-CAP group (137 cases) by carotid ultrasound examination. The levels of serum FFA and H-FABP were detected by enzyme-linked immunosorbent assay (ELISA); Logistic multiple factor regres-sion was applied to analyze the influencing factors of CAP; the levels of serum FFA, H-FABP and their correlation with clinical data were analyzed by Spearman method; Receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic efficacy ofserum FFA, H-FABP and their combination for CAP.Results Compared with non-CAP group, the age, history of hypertension, C-reac-tive protein (CRP), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL), apolipoprotein A (ApoA), FFA, H-FABP [(4.63±1.43) μg/Lvs.(3.68±1.05)μg/L] levels in CAP group increased obviously (P<0.05), the level of LPA decreased obviously (P<0.05). Logistic analysis showed that age, CRP, TG, LDL, FFA and H-FABP were independent risk factors for CAP in T2DM patients (P<0.05). The se-rum FFA of T2DM patients with CAP was positively correlated with the levels of H-FABP, age, CRP, TG and LDL (r=0.61, 0.59, 0.52, s0.57, 0.55, P<0.05). Serum H-FABP was positively correlated with age, CRP, TG and LDL levels (r=0.58, 0.53, 0.57, 0.54, P<0.05). sThe ROC curve results showed that the AUC of FFA, H-FABP levels in serum and their combination in predicting CAP in T2DM pa-tients were 0.71, 0.74 and 0.84, respectively, and the AUC of combined prediction was obviously higher than that of the two alone (Z= 3.65, 2.68, P<0.05).Conclusion The levels of FFA and H-FABP increase in the serum of T2DM patients with CAP, which are closelyrelated to age, CRP, TG and LDL, and are expected to become diagnostic factors for the occurrence of CAP in T2DM patients. |
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