| 邹红,黄伟,朱丹,等.加味半夏泻心汤联合盐酸西替利嗪片递减法治疗慢性自发性荨麻疹(脾虚湿热证)疗效观察[J].安徽医药,2025,29(1):169-173. |
| 加味半夏泻心汤联合盐酸西替利嗪片递减法治疗慢性自发性荨麻疹(脾虚湿热证)疗效观察 |
| Clinical observation on the treatment of chronic spontaneous urticaria (spleen deficiency and damp heat syndrome) with Banxia Xiexin decoction and cetirizine hydrochloride tablets |
| |
| DOI：10.3969/j.issn.1009-6469.2025.01.035 |
| 中文关键词: 荨麻疹 半夏泻心汤 盐酸西替利嗪片 脾虚湿热证 临床疗效 |
| 英文关键词: Urticaria Banxia Xiexin decoction Cetirizine hydrochloride tablets Spleen deficiency damp heat syndrome Clini-cal efficacy |
| 基金项目:四川省中医药管理局科学技术研究专项课题项目( 2020LC0102) |
|
| 摘要点击次数: 479 |
| 全文下载次数: 226 |
| 中文摘要: |
| 目的观察加味半夏泻心汤联合盐酸西替利嗪片递减法对慢性自发性荨麻疹(脾虚湿热证)的临床疗效。方法选取 2021年 1月至 2022年 6月达州市中西医结合医院确诊的慢性自发性荨麻疹(脾虚湿热证) 70例，采用随机数字表分为治疗组与对照组，每组各 35例。对照组给予西替利嗪片递减法治疗，治疗组在对照组基础上联用加味半夏泻心汤。两组总疗程为 6周。在治疗第 4周及第 6周开始时，观察两组病人盐酸西替利嗪片使用情况，并于第 6周治疗结束后，观察两组病例的临床疗效、西替利嗪片使用总量、荨麻疹活动度评分( UAS)及皮肤生活质量指数( DQLI)评分、血清总免疫球蛋白 E(IgE)值、不良反应。并于治疗结束后 8周统计复发情况。结果研究实际完成 60例，两组各 30例。治疗第 4周及第 6周开始时，治疗组盐酸西替利嗪片使用间隔时间明显高于对照组(治疗组西药减量速度高于对照组)(P<0.05)。 6周后，治疗组治愈率为 53.33%(16/30)对照组治愈率为20%(6/30)；治疗组治愈率明显高于对照组(P<0.05)；治疗组病人西替利嗪片使用总量明显低于对照组(P<0.05)治疗组 UAS及 DQLI评分比对照组低( P<0.05)；不良反应两组无差异。疗程结束以后 8周随访，复发率治疗组比对照组显著(P<0.05)。结论加味半夏泻心汤联合盐酸西替利嗪片递减法治疗慢性自发性荨麻疹(脾虚湿热证)临床疗效确切，降低，可明显缩短病程，降低复发率。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of Banxia Xiexin decoction combined with cetirizine hydrochloride tablets inthe treatment of chronic spontaneous urticaria (spleen deficiency and damp heat syndrome).Methods A total of 70 cases of chronic spontaneous urticaria (spleen deficiency damp heat syndrome) diagnosed in the dermatological clinic of Dazhou Integrated Hospital ofTraditional Chinese and Western Medicine from January 2021 to June 2022 were randomly divided into treatment group and control group using a random number table, with 35 cases in each group. The control group was treated with cetirizine tablets, while the treat-ment group was treated with Banxia Xiexin decoction combined with cetirizine hydrochloride tablets.The total course of treatment was 6weeks.At the beginning of the 4th and 6th week of treatment, the use of cetirizine hydrochloride tablets in the two groups was observed,and at the end of the 6th week of treatment, the clinical efficacy, total use of cetirizine tablets, urticaria activity score (UAS) and skinquality of life index (DQLI) scores, serum total immunoglobulin E (IgE) values, and adverse reactions of the two groups were observed.The recurrence was measured 8 weeks after treatment.Results A total of 60 cases were completed in this study,each group had 30 cas-es. At the beginning of the 4th and 6th week of treatment, the interval between the use of cetirizine hydrochloride tablets in the treat-ment group was clearly higher than that in the control group (the reduction rate of western medicine in the treatment group was higherthan that in the control group) (P<0.05). After 6 weeks, the cure rate of the treatment group was 53.33% (16/30), while the cure rate ofthe control group was 20% (6/30), the recovery rate in the treatment group was higher than that in the control group (P<0.05); UAS and DQLI scores in the treatment group were lower than those in the control group (P<0.05); There was no obviously difference in adversereactions between the two groups. Follow up 8 weeks after the treatment, the recurrence rate of treatment group was lower than that ofcontrol group (P<0.05).Conclusion The clinical effect of Banxia Xiexin decoction combined with cetirizine hydrochloride tablets inthe treatment of chronic spontaneous urticaria (spleen deficiency damp heat syndrome) is definite, which can significantly shorten thecourse of disease and reduce the recurrence rate. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
